The cyclic GMP-AMP (cGAMP) synthase (cGAS) and stimulator of interferon genes (STING) pathway, a crucial component of host innate immunity, detects aberrant DNA during viral infection. It is well established that cGAS-STING signaling activation during viral infections is often insufficient for complete viral clearance, indicating that numerous viruses have evolved countermeasures against this major pathway. However, the precise mechanisms by which viruses antagonize the cGAS-STING pathway to ensure intracellular survival remain incompletely understood. This review synthesizes recent progress in elucidating how diverse RNA and DNA viruses disrupt various stages of cGAS-STING pathway activation. These mechanistic insights into viral evasion have significant implications for the development of targeted therapeutic interventions.
Here is Emergent Garden’s thoughts on emergent complexity. I go through a tour of simple systems that produce unexpected complexity, and try to break down emergence into more general and useful ideas. We talk about snowflakes and ant colonies, cellular automata and universe simulations, and the many weird ideas of Stephen Wolfram. I also offer some advice for creating and encouraging emergent behavior. This video is important to me. Emergence is the most interesting thing in the universe.
The rapid acceleration of the universe’s expansion continues to challenge our understanding of fundamental physics. Why the universe is expanding faster and faster remains one of the most intriguing open questions in modern physics. Current theories cannot fully account for this behavior using th
This Review summarizes epidemiology and risk factors, clinical presentations, pathogenesis, assessment and diagnosis, treatment and prognosis, screening and surveillance, and prevention of keratinocyte carcinomas.
New: Alexandra Prado-Mantilla, Terry Lechler et al. develop a mouse line to allow cell type–specific, rapid, and reversible degradation of GFP-tagged proteins.
Prado-Mantilla et al. develop a mouse line to allow cell type–specific, rapid, and reversible degradation of GFP-tagged proteins. Using this line, they dem.
Long-term satellite measurements show that Earth’s magnetic field is changing faster and more unevenly than expected, driven by dynamic processes deep within the planet’s core. Drawing on 11 years of magnetic field data collected by the European Space Agency’s Swarm satellite constellation, resea
Join AMD Chair and Chief Executive Officer, Dr. Lisa Su, for her keynote at CES 2026, the most powerful technology event in the world. Dr. Su returns to the CES stage in Las Vegas to highlight, alongside partners and customers, the AMD vision for delivering future AI solutions – from cloud to enterprise, edge and devices.