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Category: health

This Popular Diet Seems to Reduce Gum Disease, Scientists Say

There’s something rather special about the Mediterranean diet: already associated with a lower risk of Alzheimer’s disease, early death, poor mental health, and more besides, a new study links the diet to better gum health too.

The study, carried out by researchers from King’s College London and the University of Catania in Italy, involved 195 participants with an average age of 49, who were given a health check-up and quizzed on their dietary habits.

Those participants who stuck more closely to the plant-rich Mediterranean diet were less likely to have gum disease, the data showed – especially those who didn’t eat much red meat.

Childhood stress strongly linked to chronic disease in adulthood, researchers report

Research published by Duke University researchers has found a strong link between higher stress in children and adverse health conditions for them later in life. Appearing in the journal Proceedings of the National Academy of Sciences, the study used measurable metrics of health over time to create a more quantitative view of how stress early in life affects health.

“We’ve had an idea for a long time, since the ’80s at least, that when children have adversity in their lives, it affects how their bodies work, not just psychologically, but also physiologically. It gets underneath the skin, and it becomes embodied in the way your body handles stress,” said co-author Herman Pontzer, Duke professor of evolutionary anthropology and global health.

Researchers focused on (AL), which refers to the wear and tear on the body because of chronic stress. The researchers “tested associations between childhood AL and adult cardiometabolic health,” relying on biomarkers that included antibodies of C-reactive protein, which is a marker of inflammation in the body; and the Epstein-Barr virus, which is common and highly contagious; body mass index; and .

Rising Cognitive Disability as a Public Health Concern Among US Adults

From 2013 to 2023, rates of cognitive disability nearly doubled among U.S. adults under 40.

Cognitive disability includes self-reported serious difficulty concentrating, remembering, or making decisions.

Rates are highest among people with chronic diseases or lower household incomes.

Background and Objectives.

Unlocking the immune system’s instruction manual: How T follicular helper cells mount a flexible response

Scientists have uncovered how a key type of immune cell adapts its behavior depending on the type of infection, paving the way for better vaccines and advancing research into immune-related diseases.

In their study published in Nature Immunology, a WEHI-led research team has revealed how T follicular helper (Tfh) cells tailor their instructions to the depending on the pathogen they encounter.

The findings shed light on the molecular “instruction manual” that guides and long-term immunity, offering new tools to improve vaccine design and develop targeted therapies for immune-related conditions and other major health challenges, including cancer.

Home high-intensity aerobic training outperforms balance training for cerebellar ataxias

Columbia University Medical Center-led research reports that home high-intensity aerobic training improved ataxia symptoms, fatigue, and aerobic fitness more than dose-matched home balance training in individuals with cerebellar ataxias.

Cerebellar ataxias are a group of different disorders marked by progressive loss of coordination that leads to disability. About 150,000 people in the US live with these conditions, with mean annual health care costs above $18,000 per person. Ongoing trials are searching for treatments that slow disease progression and improve functional abilities. Clinical practice guidelines advise balance training for .

Previous work in ataxia has centered on balance-focused programs that can improve Scale for the Assessment and Rating of Ataxia (SARA) scores by 1.0 to 2.8 points when exercises are sufficiently challenging, a range that meets or exceeds the minimal clinically significant difference of 1.0 point.

Novel gene therapy for hereditary hearing loss developed at Tel Aviv University

Scientists from the Gray Faculty of Medical & Health Sciences at Tel Aviv University introduced an innovative gene therapy method to treat impairments in hearing and balance caused by inner ear dysfunction. According to the researchers, “This treatment constitutes an improvement over existing strategies, demonstrating enhanced efficiency and holds promise for treating a wide range of mutations that cause hearing loss.”

The study was led by Prof. Karen Avraham, Dean of the Gray Faculty of Medical & Health Sciences, and Roni Hahn, a PhD student from the Department of Human Molecular Genetics and Biochemistry. The study was conducted in collaboration with Prof. Jeffrey Holt and Dr. Gwenaëlle Géléoc from Boston Children’s Hospital and Harvard Medical School and was supported by the US-Israel Binational Science Foundation (BSF), the National Institutes of Health/NIDCD and the Israel Science Foundation Breakthrough Research Program. The study was featured on the cover of the journal EMBO Molecular Medicine.

Prof. Avraham explains: “The inner ear consists of two highly coordinated systems: the auditory system, which detects, processes, and transmits sound signals to the brain, and the vestibular system, which enables spatial orientation and balance. A wide range of genetic variants in DNA can affect the function of these systems, leading to sensorineural hearing loss and balance problems. Indeed, hearing loss is the most common sensory impairment worldwide, with over half of congenital cases caused by genetic factors. In this study, we aimed to investigate an effective gene therapy for these cases using an approach that has not been applied in this context before.”

Drinking any amount of alcohol likely increases dementia risk

Drinking any amount of alcohol likely increases the risk of dementia, suggests the largest combined observational and genetic study to date, published in BMJ Evidence-Based Medicine.

Even light drinking—generally thought to be protective, based on observational studies—is unlikely to lower the risk, which rises in tandem with the quantity of alcohol consumed, the research indicates.

Current thinking suggests that there might be an “optimal dose” of alcohol for brain health, but most of these studies have focused on and/or didn’t differentiate between former and lifelong non-drinkers, complicating efforts to infer causality, note the researchers.

A Simple Test Strip That Reveals the Invisible Nanoplastic Threat

Researchers at the University of Stuttgart have created an “optical sieve” capable of detecting minute nanoplastic particles. Functioning much like a test strip, this innovation is designed to provide a new analytical tool for environmental and health research. Researchers from the University of

Scientists Advance Prospects for Permanently Putting AIDS Virus into Dormant State Using Gene Therapy

In a study of human immune cells infected with HIV, the virus that causes AIDS, scientists at Johns Hopkins Medicine say a molecule within HIV itself can be manipulated and amplified to force the virus into long-term dormancy, a state in which HIV does not replicate.

The Johns Hopkins team that conducted the new study had previously shown that the molecule of interest, an “antisense transcript,” or AST, is produced by HIV’s genetic material and is part of a molecular pathway that essentially puts the virus to sleep, a state known as viral latency.

The study’s leader, Fabio Romerio, Ph.D., associate professor of molecular and comparative pathobiology at the Johns Hopkins University School of Medicine, says the new findings add to a growing body of evidence that may help researchers develop a gene therapy that boosts AST production. A report on the research, funded by the National Institutes of Health, was published May 9 in Science Advances.

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