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Category: health

Scientists have identified a key nucleolar complex that could be instrumental in combating neurodegenerative diseases. This complex plays a critical role in maintaining cellular health by regulating protein homeostasis (proteostasis)—the process by which cells ensure proper protein balance and function.

Research reveals that suppressing this nucleolar complex significantly reduces the toxic effects of proteins associated with Alzheimer’s.

Alzheimer’s disease is a progressive neurological disorder that primarily affects older adults, leading to memory loss, cognitive decline, and behavioral changes. It is the most common cause of dementia. The disease is characterized by the buildup of amyloid plaques and tau tangles in the brain, which disrupt cell function and communication. There is currently no cure, and treatments focus on managing symptoms and improving quality of life.

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Per-and polyfluorinated alkyl substances (PFAS) earn their “forever chemical” moniker by persisting in water, soil and even the human brain. This unique ability to cross the blood-brain barrier and accumulate in brain tissue makes PFAS particularly concerning, but the underlying mechanism of their neurotoxicity must be studied further.

To that end, a new study by University at Buffalo researchers has identified 11 genes that may hold the key to understanding the brain’s response to these pervasive chemicals commonly found in everyday items. The paper is published in the journal ACS Chemical Neuroscience.

These genes, some involved in processes vital for neuronal health, were found to be consistently affected by PFAS exposure, either expressing more or less, regardless of the type of PFAS compounds tested. For example, all compounds caused a gene key for neuronal cell survival to express less, and another gene linked to neuronal cell death to express more.

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The World Health Organization, WHO, has declared the outbreak of a new coronavirus in China, a global health emergency.

The WHO Director-General Tedros Ghebreyesus made the announcement at a press conference in Geneva.

WHO’s emergency committee on the epidemic had reportedly met Thursday afternoon and recommended designating the outbreak a Public Health Emergency of International Concern, PHEIC.

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The World Health Organization (WHO) has declared the mpox outbreak in parts of Africa a public health emergency of international concern.

The highly contagious disease — formerly known as monkeypox — has killed at least 450 people during an initial outbreak in the Democratic Republic of Congo.

It has now spread across parts of central and east Africa, and scientists are concerned about how fast a new variant of the disease is spreading and its high fatality rate.

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Research reveals distinct mechanisms underlying neonatal and post-pubertal social behaviors, providing valuable insights for developing targeted early interventions.

Researchers from the University of Texas Health Science Center at San Antonio and Hirosaki University have unveiled significant findings on the development of social behaviors in fragile X syndrome, the most common genetic cause of autism spectrum disorder. The study, published in Genomic Psychiatry, highlights the effects of a specific prenatal treatment on social behaviors in mice.

The researchers found that administering bumetanide—a drug that regulates chloride levels in neurons—to pregnant mice restored normal social communication in newborn pups with the fragile X mutation. However, they also discovered an unexpected outcome: the same treatment reduced social interaction after puberty in both fragile X and typical mice. These findings shed light on the complex and developmental-stage-specific effects of interventions for fragile X syndrome.

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Ebola is a deadly hemorrhagic disease caused by a virus that is endemic in parts of East-Central and West Africa. Most people are aware that a primary route for person-to-person transmission is through contact with bodily fluids from an infected person. But more recent outbreaks, including the 2013–2016 Ebola epidemic in West Africa, demonstrated that infectious Ebola virus (EBOV) is also found on the skin’s surface of those who have succumbed to infection or at late times during infection.

Although evidence suggests that EBOV can be passed on from skin contact with a person in the later stages of the disease, very little is known about how the virus makes its way out of the body and onto the skin’s surface.

Researchers at University of Iowa Health Care and colleagues at Texas Biomedical Research Institute and Boston University have traced a cellular route the virus uses to traverse the inner and outer layers of skin and emerge onto the skin’s surface.

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The U.S. Department of Health and Human Services (HHS) has proposed updates to the Health Insurance Portability and Accountability Act of 1996 (HIPAA) to secure patients’ health data following a surge in massive healthcare data leaks.

These stricter cybersecurity rules, proposed by the HHS’ Office for Civil Rights (OCR) and expected to be published as a final rule within 60 days, would require healthcare organizations to encrypt protected health information (PHI), implement multifactor authentication, and segment their networks to make it harder for attackers to move laterally through them.

“In recent years, there has been an alarming growth in the number of breaches affecting 500 or more individuals reported to the Department, the overall number of individuals affected by such breaches, and the rampant escalation of cyberattacks using hacking and ransomware,” the HHS’ proposal says.

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Research led by Zhejiang Agriculture and Forestry University in China has performed a metadata investigation into the presence of microplastics in humans. They report a concerning relationship between micro and nanoplastic (MNP) concentrations in damaged tissues and links with multiple health conditions.

Plastic usage soared from 1.5 million metric tons in the 1950s to nearly 390.7 million in 2021. With the increased use in came elevated microscopic plastic pollution circulating in soil and waterways, eventually accumulating in the environment, food webs and human tissues.

Consistent methods to pinpoint and quantify MNPs in human tissues are lacking. Reliable data linking MNPs to human diseases are necessary for assessing potential risks and developing mitigation measures.

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Earlier, Director of the Gamaleya National Research Center for Epidemiology and Microbiology Alexander Gintsburg told TASS that the vaccine’s pre-clinical trials had shown that it suppresses tumor development and potential metastases.

MOSCOW, December 15. /TASS/. Russia has developed its own mRNA vaccine against cancer, it will be distributed to patients free of charge, General Director of the Radiology Medical Research Center of the Russian Ministry of Health Andrey Kaprin has told Radio Rossiya.

The vaccine was developed in collaboration with several research centers. It is planned to launch it in general circulation in early 2025.

© Mikhail Sinitsyn/TASS

Continue reading “Russian cancer vaccine to be free of charge — top oncologist” | >

The active ingredient in Ozempic and Wegovy, a drug called semaglutide, can have direct beneficial effects on the heart within weeks, in addition to the longer-term benefits of losing weight, an animal study has shown.

The finding suggests that people with heart disease who don’t have type 2 diabetes or obesity, which semaglutide is primarily used to treat, might also benefit from taking this kind of drug. “It may be that we’re missing a large population of people that could benefit,” says Christopher Stone at Brown University in Rhode Island.

The findings also suggest that people undergoing heart surgery could benefit if given GLP-1 agonists, the class of drugs that semaglutide belongs to, for at least a few weeks after their operation.

Image: JUAN GAERTNER/SCIENCE PHOTO LIBRARY/Alamy

Continue reading “Ozempic and Wegovy have heart health benefits beyond just weight loss” | >