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Jul 15, 2020

Deep Dive Into Big Pharma AI Productivity: One Study Shaking The Pharmaceutical Industry

Posted by in categories: biotech/medical, business, chemistry, health, information science, robotics/AI

No industry will be spared.


The pharmaceutical business is perhaps the only industry on the planet, where to get the product from idea to market the company needs to spend about a decade, several billion dollars, and there is about 90% chance of failure. It is very different from the IT business, where only the paranoid survive but a business where executives need to plan decades ahead and execute. So when the revolution in artificial intelligence fueled by credible advances in deep learning hit in 2013–2014, the pharmaceutical industry executives got interested but did not immediately jump on the bandwagon. Many pharmaceutical companies started investing heavily in internal data science R&D but without a coordinated strategy it looked more like re-branding exercise with the many heads of data science, digital, and AI in one organization and often in one department. And while some of the pharmaceutical companies invested in AI startups no sizable acquisitions were made to date. Most discussions with AI startups started with “show me a clinical asset in Phase III where you identified a target and generated a molecule using AI?” or “how are you different from a myriad of other AI startups?” often coming from the newly-minted heads of data science strategy who, in theory, need to know the market.

However, some of the pharmaceutical companies managed to demonstrate very impressive results in the individual segments of drug discovery and development. For example, around 2018 AstraZeneca started publishing in generative chemistry and by 2019 published several impressive papers that were noticed by the community. Several other pharmaceutical companies demonstrated impressive internal modules and Eli Lilly built an impressive AI-powered robotics lab in cooperation with a startup.

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Jul 15, 2020

Lockdowns return in India as coronavirus cases surge: Live

Posted by in categories: biotech/medical, government, health

British Health Minister Matt Hancock said that the government would not recommend that office workers wear face masks while at work.

“We will not be recommending masks in the office,” Hancock told Sky News on Wednesday.

Nearly a dozen Indian states have imposed a partial lockdown in high-risk areas after spikes in coronavirus cases, with the country’s infections topping 900,000 just three days after crossing the 800,000 mark.

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Jul 14, 2020

Researchers made a medical wearable using a pencil and paper

Posted by in categories: biotech/medical, health, wearables

Cheap paper and pencil-based medical wearables could one day replace expensive health monitors.

Jul 14, 2020

Two Genetic Regions Linked with Severe COVID-19

Posted by in categories: biotech/medical, genetics, health

🤔

It’s not yet clear why some people infected with SARS-CoV-2, the virus that causes COVID-19, get really sick, while others have only mild symptoms. There’s some evidence that chronic health conditions—such as hypertension and diabetes can play a role, and scientists know that people’s genes can influence how their bodies react to other viruses. In a preprint posted to medRxiv on June 2, researchers describe a genome-wide association study (GWAS) of from 1,610 hospitalized patients with COVID-19 and 2,205 healthy controls. The authors identified variants in two regions—the locus that encodes blood type and a multi-gene cluster on chromosome 3—that were linked to respiratory failure during SARS-CoV-2 infection.


In a genome-wide association study, variants in both the ABO blood group locus and a cluster of genes on human chromosome 3 are more common among COVID-19 patients with respiratory failure than in the general population.

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Jul 13, 2020

The new tattoo: Drawing electronics on skin

Posted by in categories: biotech/medical, health

One day, people could monitor their own health conditions by simply picking up a pencil and drawing a bioelectronic device on their skin. In a new study, University of Missouri engineers demonstrated that the simple combination of pencils and paper could be used to create devices that might be used to monitor personal health.

Their findings are published in the journal Proceedings of the National Academy of Sciences.

Zheng Yan, an assistant professor in the College of Engineering, said many existing commercial on-skin often contain two major components—a biomedical tracking component and a surrounding flexible material, such as plastic, to provide a supportive structure for the component to maintain an on-skin connection with a person’s body.

Jul 12, 2020

And as in most applications of #MachineLearning, healthcare #AI systems are extremely data-hungry

Posted by in categories: biotech/medical, health, robotics/AI, wearables

Very true.


And as in most applications of #MachineLearning, healthcare #AI systems are extremely data-hungry.

Fortunately, a slew of new sensors and data acquisition methods — including over 302 million wearables shipped in 2019 — are bursting onto the scene to meet the massive demand for medical data.

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Jul 10, 2020

Week 5 (6/28–7/4) Using Stem Cell Neurotherapy

Posted by in categories: biotech/medical, health

This my sleep was about the same as the previous week. I had great energy throughout the week when going through my exercise routines.

Sunday-6/28- Biked 48 km. 1 hour Yin Yoga. Stem Cell Neurotherapy 1 hour. 7 hours of sleep.

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Jul 10, 2020

Supreme Court of Canada upholds genetic non-discrimination law

Posted by in categories: genetics, health, law

Canada’s highest court has issued a ruling today upholding a federal law preventing third parties, such as employers and insurance companies, from demanding genetic information from individuals.

In a 5–4 decision, the Supreme Court of Canada has decided the Genetic Non-Discrimination Act is a constitutional exercise of federal powers.

Jul 10, 2020

Microbial management

Posted by in categories: biotech/medical, health

The human colon is home to a complex microbial ecosystem (microbiota), composed mostly of anaerobic organisms. Recent data suggest that gut microbes and their metabolites can affect human health through multiple mechanisms including altering the immune response , changing host cell metabolic states , and even affecting the response to immunotherapies.

The potential causative role of gut microbiota in health and disease is one of the most extraordinary findings of the past decade. Yet we are only starting to understand the multitude of mechanisms by which microbes promote changes in intestinal physiology, and how changes in the symbiotic relationship between the host and the resident microbiota contribute to the pathogenesis of both infectious and noninfectious diseases.

Jul 10, 2020

Study of 17 Million Identifies Crucial Risk Factors for Coronavirus Deaths

Posted by in categories: biotech/medical, health

An analysis of more than 17 million people in England — the largest study of its kind, according to its authors — has pinpointed a bevy of factors that can raise a person’s chances of dying from COVID-19, the disease caused by the coronavirus.

The paper, published Wednesday in Nature, echoes reports from other countries that identify older people, men, racial and ethnic minorities, and those with underlying health conditions among the more vulnerable populations.

“This highlights a lot of what we already know about COVID-19,” said Uchechi Mitchell, a public health expert at the University of Illinois at Chicago who was not involved in the study. “But a lot of science is about repetition. The size of the study alone is a strength, and there is a need to continue documenting disparities.”

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