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Archive for the ‘life extension’ category

Oct 2, 2022

Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325

Posted by in categories: biotech/medical, life extension, robotics/AI

Michael Levin is a biologist at Tufts University working on novel ways to understand and control complex pattern formation in biological systems. Please support this podcast by checking out our sponsors:
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EPISODE LINKS:
Michael’s Twitter: https://twitter.com/drmichaellevin.
Michael’s Website: https://drmichaellevin.org.
Michael’s Papers:
Biological Robots: https://arxiv.org/abs/2207.00880
Synthetic Organisms: https://tandfonline.com/doi/full/10.1080/19420889.2021.2005863
Limb Regeneration: https://science.org/doi/10.1126/sciadv.abj2164

Continue reading “Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325” »

Oct 1, 2022

George Church on the state of aging research — present and future (videoclip)

Posted by in categories: genetics, life extension

Excerpt from an episode of Longevity by Design, hosted by Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD, who were joined by Dr. George Church, Professor of Genetics at Harvard Medical School.

To watch the entire conversation clic here: https://youtu.be/6XnXeVS1m2U

Sep 30, 2022

Jennifer Garrison, Buck Institute | Reframing Health and Aging through the Lens of Reproduct

Posted by in categories: biotech/medical, computing, life extension, nanotechnology

Foresight Biotech & Health Extension Meeting sponsored by 100 Plus Capital.
Program & apply to join: https://foresight.org/biotech-health-extension-program/

Jennifer Garrison, Buck Institute.
Reframing Health and Aging through the Lens of Reproduct.

Continue reading “Jennifer Garrison, Buck Institute | Reframing Health and Aging through the Lens of Reproduct” »

Sep 30, 2022

Towards the interpretability of deep learning models for multi-modal neuroimaging: Finding structural changes of the ageing brain

Posted by in categories: biotech/medical, life extension, robotics/AI

Brain-age (BA) estimates based on deep learning are increasingly used as neuroimaging biomarker for brain health; however, the underlying neural features have remained unclear. We combined ensembles of convolutional neural networks with Layer-wise Relevance Propagation (LRP) to detect which brain features contribute to BA. Trained on magnetic resonance imaging (MRI) data of a population-based study (n = 2,637, 18–82 years), our models estimated age accurately based on single and multiple modalities, regionally restricted and whole-brain images (mean absolute errors 3.37–3.86 years). We find that BA estimates capture ageing at both small and large-scale changes, revealing gross enlargements of ventricles and subarachnoid spaces, as well as white matter lesions, and atrophies that appear throughout the brain. Divergence from expected ageing reflected cardiovascular risk factors and accelerated ageing was more pronounced in the frontal lobe. Applying LRP, our study demonstrates how superior deep learning models detect brain-ageing in healthy and at-risk individuals throughout adulthood.

Sep 30, 2022

Aubrey de Grey’s main short-term focus on his next endeavour (videoclip with S/T in Spanish)

Posted by in category: life extension

I just uploaded in my YouTube channel my latest videoclip.

It’s an excerpt of an interview made few days ago by Phil Newman, Editor-in-Chief of Longevity. Technology to Aubrey de Grey.

Continue reading “Aubrey de Grey’s main short-term focus on his next endeavour (videoclip with S/T in Spanish)” »

Sep 30, 2022

Mouse study suggests genetics of longevity are influenced by both gender and age

Posted by in categories: biotech/medical, genetics, life extension

A team of researchers affiliated with several institutions in Switzerland and the U.S. reports evidence that the genetics of longevity are influenced by both gender and age. In their paper published in the journal Science, the group describes their study of aging in mice and humans. João Pedro de Magalhães, with the University of Birmingham, has published a Perspective piece in the same journal issue outlining the technical challenges to understanding how aging works and the work done by the team on this new effort.

Scientists have been studying the for many years but still do not have a good explanation for why organisms age and why some live longer than others. In this new effort, the researchers wondered if something in the genome plays a role in how long a species lives on average.

Noting that another team had created a very large dataset of information regarding aging in nearly 3,000 mice, the researchers found that it also contained . After obtaining access to the database, they analyzed that genetic information—more specifically, they conducted quantitative trait locus mapping. They found multiple loci that they could associate with longevity, some that were specific to one or the other gender. They also found that mice who weighed more during their early years or who had small litter sizes tended to die younger. They suggest the same that were associated with aging may have also played a role in the other two traits. The researchers also found that the aging-related genes they isolated appeared to remain dormant until the latter stages of a given individual’s life.

Sep 30, 2022

Viral infections including COVID are among the important causes of dementia. One more reason to consider vaccination

Posted by in categories: biotech/medical, life extension, neuroscience

With more of us living into old age than at any other time, dementia is increasing steadily worldwide, with major individual, family, societal and economic consequences.

Treatment remains largely ineffective and aspects of the underlying pathophysiology are still unclear. But there is good evidence that —and their manifestation as dementia—are not an inevitable consequence of aging.

Many causes of dementia, including viral infections, are preventable.

Sep 29, 2022

Drinking 2 to 3 cups of coffee per day could have a surprising effect on longevity

Posted by in categories: biotech/medical, chemistry, food, life extension

Including decaffeinated and instant ones.

A new study conducted by Australian scientists suggests that consuming two to three cups of decaffeinated, ground, and instant coffee can lower the risk of developing cardiovascular disease and dying early.

“In this large, observational study, ground, instant, and decaffeinated coffee were associated with equivalent reductions in the incidence of cardiovascular disease and death from cardiovascular disease or any cause,” says study author Professor Peter Kistler of the Baker Heart and Diabetes Research Institute in a media release.

Continue reading “Drinking 2 to 3 cups of coffee per day could have a surprising effect on longevity” »

Sep 29, 2022

Dr. Doris A. Taylor, Ph.D. — CEO, Organamet Bio Inc. — Personalized Bio-Engineered Human Hearts

Posted by in categories: chemistry, engineering, life extension, sex

Personalized Bio-Engineered Human Hearts For All — Dr. Doris A. Taylor, Ph.D., CEO, Organamet Bio Inc.


Dr. Doris A. Taylor, Ph.D. is Chief Executive Officer of Organamet Bio Inc. (https://organametbio.com/) an early phase start-up committed to saving lives and reducing the cost of healthcare for those with heart disease. Organamet has a goal is to make personalized bio-engineered human hearts, available to all who need them, within 5 years, increasing availability and access to hearts, decreasing or eliminating need for immunosuppression, reducing total lifetime transplant costs, and improving quality of life.

Continue reading “Dr. Doris A. Taylor, Ph.D. — CEO, Organamet Bio Inc. — Personalized Bio-Engineered Human Hearts” »

Sep 27, 2022

Epigenetic aging and perceived psychological stress in old age

Posted by in categories: genetics, life extension, neuroscience

Additionally, epigenetic changes were suggested to be a possible link [30, 31] between adverse childhood experiences and mortality as well as higher morbidity burden in late life [32]. It was proposed that this link could be mediated by health-adverse coping mechanisms (activated as a result of high levels of anxiety and depression) that are associated with adverse childhood experiences [33]. Some of these coping strategies, such as smoking, alcohol abuse and and a high BMI resulting from unhealthy eating habits, were shown to be associated with DNAmAA in some studies [34,35,36]. However, these results were not unequivocally replicated [37,38,39] (reviewed in ref. [40]).

Previous studies that examined the relationship between DNAmAA and stress operationalized stress as low socioeconomic status (SES) [41, 42], (childhood) trauma [26, 43,44,45], racial discrimination [46], or exposure to violence [47]. Many previous studies on the topic focused on changes in DNAm age during childhood as this period is known to be particularly prone to stress-related epigenetic changes [29].

In contrast, in this work we focus on older age which was shown to be the second most vulnerable phase in a person’s life in terms of epigenetics [29]. As epigenetic modifications remain even after the psychological stimulus has ceased there is the possibility of cumulating effects on the epigenome exerted by repeated psychological stressors [29]. Specifically, we analyzed the association between the amount of experienced stress (measured by Cohen’s Perceived Stress Scale [PSS] [48]) and several DNAm age estimators (i.e. the 7-CpG clock [49], Horvath’s clock [50], Hannum’s clock [51], PhenoAge [34], GrimAge [52]) in 1,100 older adults. While the PSS represents a well-established marker of perceived stress [48], to our knowledge it has not been investigated in the context of epigenetic aging before. While we were able to replicate well-established associations with perceived stress, none of the five epigenetic clocks analyzed in the current study were associated with the perception of stress.

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