Organ-specific age gaps showed strong associations with cancers affecting the corresponding organ. The strongest association was observed between kidney biological age and renal cancer (HR, 1.6). Organ-specific aging in lungs and intestines also increased the risk of lung cancer and stomach cancer, respectively (HR, 1.4 for both). The sensitivity analysis yielded largely similar results, except for attenuations in kidney and lung cancer, indicating the robustness of the primary findings.

The Global Proteomic Aging Clock predicted mortality from any cause as accurately as conventional risk factors. Combining the findings with established risk factors further improved mortality prediction compared with using risk factors alone.

The biology behind Project Hail Mary’s coma pods is one of the most important untapped pathways in longevity medicine

Researchers from the University of Colorado Boulder, CU Anschutz, and Colorado State University have developed a set of experimental treatments that may help aging and damaged joints repair themselves in a matter of weeks. The therapies have shown promising results in animal studies, where they reversed signs of osteoarthritis and restored joint health.

The new approaches include a regenerative injection designed to be administered directly into a joint, as well as a biomaterial-based repair system that encourages the body’s own cells to rebuild damaged cartilage.

The work recently received a major boost from the federal Advanced Research Projects Agency for Health (ARPA-H), which announced that the team will move forward to the next stage of a project worth up to $33.5 million. The research is part of the ARPA-H Novel Innovations for Tissue Regeneration in Osteoarthritis (NITRO) program, led by ARPA-H Program Manager Dr. Ross Uhrich.

Oppezzo and colleagues report that therapeutically blocking telomeric DNA damage signaling reduces senescence and inflammation and restores hematopoietic function in telomerase-deficient and physiologically aged mice.