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Archive for the ‘life extension’ category

Mar 30, 2020

Researcher on aging confronts his own mortality

Posted by in categories: biotech/medical, life extension, neuroscience

His work transformed the mind-set of scientists, launching a new field in the science of aging when he demonstrated that identifying and manipulating genes could lengthen life span.

Although Johnson’s research has led to drug development to slow the effects of age-related diseases, he has yet to find the secret to stop aging. Now the soft-spoken redheaded scientist is running out of time as he confronts his own mortality.


In 1987, scientist Tom Johnson’s team identified the first gene that affects aging. Today, he still works in his lab as he deals with incurable Lewy body dementia.

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Mar 28, 2020

Scientists Have ‘Reset’ The Cellular Age Of Cells Taken From A 114-Year-Old Woman

Posted by in categories: biotech/medical, genetics, life extension, neuroscience

For the first time, scientists have reprogrammed cells from a 114-year-old woman into induced pluripotent stem cells (iPS cells), a move which they describe as a significant step toward understanding “the underlying mechanisms of extreme longevity and disease resistance.”

iPS cells are adult cells that have been genetically reprogrammed into an embryonic stem cell-like state and are able to give rise to any of the specialized cell types of the body, whether it’s neurons, blood cells, or heart cells.

Until this new project, researchers weren’t even certain whether they could create viable iPS cells from someone so elderly, let alone a supercentenarian. Now they have shown it’s possible to effectively make these aged cells resemble young pluripotent cells, the researchers believe they might have made a step towards the reversal of cellular aging.

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Mar 27, 2020

MitoMouse March Update – Backer Rewards Delayed

Posted by in category: life extension

Lifespan.io


Mar 27, 2020

How one Scientist Reversed Aging in Humans

Posted by in category: life extension

On this episode of Anti-Aging Hacks, we discuss all about reversing aging in humans! My guest in this podcast is Dr. Greg Fahy, and he is the first scientist to reverse aging in humans. Here is what we discuss in this interview: 1. Why the Thymus is really important for Immune Function 2. How creating a combination.

Mar 26, 2020

WSCS16 — Day 3 — The Future of Human Aging

Posted by in categories: biotech/medical, life extension

The Future of Human Aging: Implications of Induced Tissue Regeneration (iTR), with Michael D. West, Ph.D., Co-CEO of BioTime.

Mar 25, 2020

Stem cell technique winds back aging in human cells

Posted by in categories: biotech/medical, life extension

O,.,o.


Stanford scientists may have found a way to essentially return older cells to a more youthful state. The adult cells are treated with a mix of proteins from early embryonic development, which removes many of the molecular signs of aging. The cells closely resembled younger ones, and in mouse tests, older animals regained the muscle strength of youth.

Stem cells have the remarkable ability to differentiate into basically any other type of cell in the body. That’s not only important for healthy development of embryos, but it opens an intriguing possible treatment for replenishing lost cells to repair damage to organs and tissues.

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Mar 25, 2020

Old human cells rejuvenated with stem cell technology

Posted by in categories: biotech/medical, life extension

Old human cells can become more youthful by coaxing them to briefly express proteins used to make induced pluripotent cells, Stanford researchers and their colleagues have found. The finding may have implications for aging research.

Mar 25, 2020

Scientists ‘Reset’ The Age of Stem Cells From a Supercentenarian Who Lived to 114

Posted by in categories: biotech/medical, life extension

For the first time, scientists have reprogrammed the stem cells of a 114-year-old woman, the oldest donor to date.

After first transforming cells from her blood sample into induced pluripotent stem cells (iPSCs), the researchers then generated mesenchymal stem cells, which help to maintain and repair tissues like bone, cartilage and fat.

“We set out to answer a big question: Can you reprogram cells this old?” says stem cell biologist Evan Snyder at Sanford Burnham Prebys Medical Discovery Institute in California.

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Mar 24, 2020

Old human cells rejuvenated with stem cell technology, Stanford-led study finds

Posted by in categories: biotech/medical, life extension

Old human cells return to a more youthful and vigorous state after being induced to briefly express a panel of proteins involved in embryonic development, according to a new study by researchers at the Stanford University School of Medicine.

The researchers also found that elderly mice regained youthful strength after their existing muscle stem cells were subjected to the rejuvenating protein treatment and transplanted back into their bodies.

The proteins, known as Yamanaka factors, are commonly used to transform an adult cell into what are known as induced pluripotent stem cells, or iPS cells. Induced pluripotent stem cells can become nearly any type of cell in the body, regardless of the cell from which they originated. They’ve become important in regenerative medicine and drug discovery.

Mar 24, 2020

Turning Back the Clock on Aging Cells

Posted by in categories: biotech/medical, life extension

Researchers at Stanford University report that they can rejuvenate human cells by reprogramming them back to a youthful state. They hope that the technique will help in the treatment of diseases, such as osteoarthritis and muscle wasting, that are caused by the aging of tissue cells.

A major cause of aging is thought to be the errors that accumulate in the epigenome, the system of proteins that packages the DNA and controls access to its genes. The Stanford team, led by Tapash Jay Sarkar, Dr. Thomas A. Rando and Vittorio Sebastiano, say their method, designed to reverse these errors and walk back the cells to their youthful state, does indeed restore the cells’ vigor and eliminate signs of aging.

In their report, published on Tuesday in Nature Communications, they described their technique as “a significant step toward the goal of reversing cellular aging” and could produce therapies “for aging and aging-related diseases.”

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