Follistatin is opening new questions around baseline muscle, fat distribution, and aging. The real shift: from chasing gains → to preserving capacity.
Category: life extension
Dying stars are devouring giant planets, astronomers discover
A new study suggests that aging stars may be wiping out the giant planets that orbit closest to them. The research, led by astronomers at UCL (University College London) and the University of Warwick, provides fresh evidence that these planets can be pulled inward and destroyed as their host stars evolve.
Stars like our Sun eventually run out of hydrogen fuel. When that happens, they begin to cool and expand, entering a phase known as a red giant. Scientists estimate that the Sun will reach this stage in about five billion years.
The new findings, published in the Monthly Notices of the Royal Astronomical Society, are based on observations of nearly half a million stars that have recently entered this “post-main sequence” phase of their life cycle.
The long-lived immune system of centenarians
What is unique about the immune system of people who live to extreme old age? Here the authors describe that centenarians may achieve such longevity through several mechanisms, including limiting the pathological effects of inflammageing and immunosenescence, preservation of immune surveillance, sustained gut microbial diversity and maintenance of intestinal barrier integrity.
Arthritis Cure BREAKTHROUGH: Regrow Young Cartilage
Stanford published a paper in Science showing they regrew joint cartilage in aging mice — and in human tissue samples taken from knee-replacement patients — by blocking a single enzyme called 15-PGDH. It’s being hyped as the end of knee and hip replacement surgery. The science is real. The hype is getting ahead of what the paper actually says.
This episode walks through the study itself — the three experiments, the surprising mechanism (which doesn’t involve stem cells at all), and the actual clinical timeline.
Bottom line: the mechanism is a genuinely new paradigm for tissue regeneration. The human osteoarthritis trial? \.
The Immune System Impacts Longevity: What To Measure
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Research Into Naturally Occurring Hair Growth in Skin Nevi May Inform New Regenerative Therapies
An international team of researchers funded in part by NIAMS sought to understand why skin nevi grow long hair. Nevi, which are a type of skin lesion, have an abundance of pigment-producing cells, called melanocytes, that have become aged (or senescent). The team determined that senescent melanocytes within nevi produce large quantities of several signaling molecules. One such molecule, called osteopontin, causes dormant hair stem cells to wake up, which increases hair growth.
The study, which appeared in the journal Nature on June 21, 2023, provides answers as to why nevi are hairy and also uncovers the unexpected growth-promoting potential of senescent cells, which are typically thought to be associated with inhibited tissue growth.
Just two doses of new nasal spray found to slow brain ageing and restore memory
Recently, a growing body of research suggests that the brain fog one experiences as they grow older is linked to a tide of inflammation deep within the brain’s memory centre. Scientists call this “neuroinflammaging” – thought to be the inevitable price of growing older.
But now, a new mice study suggests that this inflammation behind brain ageing and brain fog can actually be reversed with a simple nasal spray. This spray could reshape the future of therapies for conditions like Alzheimer’s disease, and may even change what is known about brain ageing itself, say researchers from Texas A&M University.