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Category: life extension – Page 2
Hemoglobin’s antioxidant role in brain cells points to new therapeutic avenue
Hemoglobin, long celebrated for ferrying oxygen in red blood cells, has now been revealed to play an overlooked—and potentially game-changing—antioxidant role in the brain.
In neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Parkinson’s, Alzheimer’s, and aging, brain cells endure relentless damage from the aberrant (or excessive) reactive oxygen species (ROS). For decades, scientists have tried to neutralize ROS with antioxidant drugs, but most failed: they couldn’t penetrate the brain effectively, were unstable, or indiscriminately damaged healthy cells.
This new study, led by Director C. Justin Lee of the Center for Cognition and Sociality within the Institute for Basic Science (IBS) in Daejeon, South Korea, set out to identify the brain’s own defenses against a particularly harmful form of ROS—hydrogen peroxide (H2O2). The study has been published in Signal Transduction and Targeted Therapy.
Reproducing Rejuvenation: Inside the Pig Plasma Longevity Experiments
Could pig plasma fractions really rejuvenate aging rats? Join me as I interview Nicolás and Nina from the Rejuvenation Science Institute (Brazil), who are working to reproduce the headline-creating “pig plasma rejuvenation” results. We explore the origins, science, controversies, challenges, and hopes surrounding this research—plus their plans for the next breakthrough longevity experiment and open science collaboration.
https://www.rejuvenescimento.org/english.
https://www.rejuvenescimento.org/news… https://journals.tmkarpinski.com/inde… Timestamps 00:00 – Introduction: The Pig Plasma Rat Rejuvenation Debate 02:00 – Origins: Why try to reproduce these results? 08:30 – What is being injected? Fraction preparation explained 15:40 – Acute toxicity and safety results: did the rats survive? 26:00 – The next experiment: timelines, scale-up, and open science goals Find me on Twitter — / eleanorsheekey Support the channel through PayPal — https://paypal.me/sheekeyscience?coun… through Patreon —
/ thesheekeyscienceshow Please note that The Sheekey Science Show is distinct from Eleanor Sheekey’s teaching and research roles. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed. Icons in intro; “https://www.freepik.com/free-photos-v…Background“Background vector created by freepik — www.freepik.com.
https://journals.tmkarpinski.com/inde…
Timestamps.
00:00 – Introduction: The Pig Plasma Rat Rejuvenation Debate.
02:00 – Origins: Why try to reproduce these results?
08:30 – What is being injected? Fraction preparation explained.
15:40 – Acute toxicity and safety results: did the rats survive?
26:00 – The next experiment: timelines, scale-up, and open science goals.
Find me on Twitter — / eleanorsheekey.
Support the channel.
through PayPal — https://paypal.me/sheekeyscience?coun…
through Patreon — / thesheekeyscienceshow.
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey’s teaching and research roles. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; \.
This Protein Slows the Aging Brain, and We Know How to Counter It
Aging is particularly harsh on the hippocampus, the brain region responsible for learning and memory.
Now, researchers at UC San Francisco have identified a protein that’s at the center of this decline.
They looked at how the genes and proteins in the hippocampus changed over time in mice and found just one protein that differed between old and young animals. It’s called FTL1. Old mice had more FTL1, as well as fewer connections between brain cells in the hippocampus and diminished cognitive abilities.
Scientists discover a protein that gets concentrated in the brain during aging, leading brain connections to wither and cognitive decline to accelerate — and a way to counter its effects.
How Dr. Bill Andrews Plans to Cure Aging in 3 Years
Anybody got a spare $130 million?
Dr. Bill Andrews, a trailblazing scientist, is on a mission to cure aging. From a childhood dream sparked at age 10 to his pioneering telomerase research, he reveals how Sierra Sciences could reverse aging in just three years with $130 million in funding. Yet, investor demands for quick returns stand in his way.
He believes that a Biotech Freedom Zone through Immortalis—a revolutionary approach to bypass funding and regulatory hurdles—is the catalyst to transform longevity research, making health affordable and aging a thing of the past.
Join the community behind the first ever Biotech Freedom City:
https://joinimmortalis.com
Longevity expert explains whether we can reduce plaque build-up in our arteries and decrease the risk of a heart attack
It is a very common belief that once plaque builds up in the arteries, it is there to stay, a slow, irreversible path towards heart disease. Doctors generally prescribed lifelong medication, stents, or even surgery as the only way forward. But as longevity expert Dr Vass, trained at Cornell, points out, that it might not all be true. Science now shows that arterial plaque can indeed be managed, reduced, and even stabilised if the root causes are targeted. So, can plaque really be reversed, and can this lower the risk of heart attacks? Here’s all we need to know about it.
Why do some people age faster than others? Study identifies genes at play
It’s a fact of life: Some people age better than others. Some ease into their 90s with mind and body intact, while others battle diabetes, Alzheimer’s or mobility issues decades earlier. Some can withstand a bad fall or bout of the flu with ease, while others never leave the hospital again.
New University of Colorado Boulder-led research, published in Nature Genetics, sheds light on why that is.
In it, an international team of co-authors identifies more than 400 genes associated with accelerated aging across seven different sub-types. The study reveals that different groups of genes underlie different kinds of disordered aging, a.k.a. frailty, ranging from cognitive decline to mobility issues to social isolation.