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Category: chemistry

AI turns plain-language prompts into lab-ready recipes for novel materials

Advances in artificial intelligence promise to help chemical engineers discover complex new materials. These materials could be used for reactions such as turning carbon dioxide into fuel, but technical barriers have limited catalysis adoption so far. Researchers at the University of Rochester are now harnessing the benefits of large language models (LLMs) similar to ChatGPT, Claude, or Gemini to empower more researchers to use AI to discover new materials and accelerate experiment workflows.

In a study published in ACS Central Science, a team led by Marc Porosoff, an associate professor in the Department of Chemical and Sustainability Engineering, and Andrew White, visiting associate professor and the cofounder and chief technology officer of Edison Scientific, describes an AI based–method they developed that allows users to input natural language prompts about the materials they want to create and suggest optimal procedures for experiments to produce them. As the users run the experiments, they input the results back into the AI model and continue iterating until they reach their goal.

“We’re able to leverage the pre-trained knowledge of large language models and well-established statistical methods for materials discovery to help us as researchers navigate large experimental design spaces more efficiently,” says Porosoff.

AI and the mysteries of reality

Does AI have the potential to uncover the mysteries of reality, or does it lack the capacity for genuine discovery?

With the 2024 Nobel Prizes for physics and chemistry both awarded for AI-related science, claims that AI will soon make novel scientific breakthroughs on its own are growing louder.

Start-ups are already attempting to create “The AI Scientist,” and researchers at Imperial College argue AI will “usher in a new age of discovery to rival the golden age of the scientific method.” But critics argue the scientific capability of AI remains unknown.

Join computer scientist Roman Yampolskiy, philosopher Steve Fuller, and co-curator of “AI: More than Human” Suzanne Livingston to debate what AI can and can’t do for science.

Tap here to watch now.

The 2024 Nobel Prizes for physics and chemistry were both won for AI-related science, leading some to claim that AI will soon be making novel scientific discoveries on its own. Start-ups are already attempting to create “The AI Scientist,” which will one day “fully automate scientific discovery.” And researchers at Imperial College argue AI will.

Continue reading “AI and the mysteries of reality” | >

New laser method gives insight into radioactive atomic nuclei

By directing pulses of laser light at atoms, researchers can study how radioactive elements decay in a matter of seconds. The method is described in a new thesis from the University of Gothenburg, which shows that the atomic nuclei of the elements neptunium and fermium are shaped like rugby balls.

Actinides are a group of elements at the bottom of the periodic table. They have a high density, are radioactive, and several of them only exist for a few seconds before they decay. Only four of the 14 elements in this group occur naturally on Earth. The others can be produced in an accelerator, but only in very small quantities. Uranium is the best-known actinide, but a new thesis from the University of Gothenburg focuses on neptunium and fermium.

Fields as Formal Causes, with David Bentley Hart

In this conversation, Rupert Sheldrake and David Bentley Hart delve into the concept of fields in physics, discussing their nature as non-material formative causes and their historical context in scientific thought. They explore the idea that fields, such as gravitational and electromagnetic, act as top-down causes, aligning with Aristotle’s formal and final causes, and argue for a re-evaluation of these ancient concepts in modern science.

Chapter List:

00:00 — Introduction.
01:14 — Exploring Fields as Causes in Nature.
02:08 — Magnetic Fields and Formative Processes.
04:19 — Gravitational Fields and Formative Effects.
06:10 — Aristotle’s Formal and Final Causes.
07:32 — Challenges in Understanding Fields.
09:09 — Fields as Top-Down Causes.
10:34 — Morphic Fields and Formative Causation.
12:23 — Information Theory vs. Form.
14:15 — Fields and Order in Physics.
17:15 — Semantic and Syntactic Information.
18:18 — Universal Gravitational Field.
19:44 — Strong and Weak Nuclear Fields.
21:18 — History of Field Theory and Ether.
23:14 — Gilbert’s Magnetic Theory.
24:46 — Mind-like Structure in Nature.
25:39 — Combination of Top-Down and Bottom-Up Theories.
27:07 — Mechanistic Models and Their Limitations.
28:52 — Recovering Aristotelian Causality.
31:39 — Conclusion and Reflection on Fields as Modern Souls.

—
Dr Rupert Sheldrake, PhD, is a biologist and author best known for his hypothesis of morphic resonance. At Cambridge University, as a Fellow of Clare College, he was Director of Studies in biochemistry and cell biology. As the Rosenheim Research Fellow of the Royal Society, he carried out research on the development of plants and the ageing of cells, and together with Philip Rubery discovered the mechanism of polar auxin transport. In India, he was Principal Plant Physiologist at the International Crops Research Institute for the Semi-Arid Tropics, where he helped develop new cropping systems now widely used by farmers. He is the author of more than 100 papers in peer-reviewed journals and his research contributions have been widely recognized by the academic community, earning him a notable h-index for numerous citations. On ResearchGate his Research Interest Score puts him among the top 4% of scientists.

https://www.sheldrake.org

‘Interstellar glaciers’: NASA’s SPHEREx maps vast galactic ice regions

NASA’s SPHEREx (Spectro-Photometer for the History of the Universe, Epoch of Reionization, and Ices Explorer) mission has mapped interstellar ice at an unprecedented scale. Covering regions in our Milky Way galaxy more than 600 light-years across, the ice was found inside giant molecular clouds—vast regions of gas and dust where dense clumps of matter collapse under gravity, giving birth to stars. A study describing these findings was published Wednesday in The Astrophysical Journal.

One of SPHEREx’s main goals is to map the chemical signatures of various types of interstellar ice. This ice includes molecules like water, carbon dioxide, and carbon monoxide, which are vital to the chemistry that allows life to develop. Researchers believe these ice reservoirs, attached to the surfaces of tiny dust grains, are where most of the universe’s water is formed and stored. The water in Earth’s oceans —and the ices in comets and on other planets and moons in our galaxy—originates from these regions.

“These vast frozen complexes are like ‘interstellar glaciers’ that could deliver a massive water supply to new solar systems that will be born in the region,” said study co-author Phil Korngut, the instrument scientist for SPHEREx at Caltech in Pasadena, California. “It’s a profound idea that we are looking at a map of material that could rain on nascent planets and potentially support future life.”

Marine sponge bacterium enzyme reveals a two-part route to make terpenoids

The molecular structure of an enzyme from a marine bacterium with potential industrial uses has been determined by RIKEN researchers. The insights they have gained could help make a range of useful compounds through genetic modification. The research is published in the journal Chemical Science.

The class of natural compounds known as terpenoids is nothing if not versatile, being used in a wide assortment of products, from perfumes and insect repellents to pesticides and drugs. More than 100,000 terpenoids have been identified so far. They are produced by an impressive range of organisms spanning animals, plants, fungi, bacteria, and viruses.

Recently, marine organisms such as corals, sponges, and marine bacteria have been found to produce terpenoids with complex structures that show promise for fighting infectious diseases.

Dark matter could explain the earliest supermassive black holes

A growing mystery in astronomy is the presence of gargantuan black holes—some weighing as much as a billion suns—existing less than a billion years after the Big Bang. According to the standard theory of black hole formation, these black holes simply should not have had enough time to grow so large. A study led by University of California, Riverside graduate student Yash Aggarwal shows that dark matter decays could be the key to understanding the origin of these cosmic behemoths. Published in the Journal of Cosmology and Astroparticle Physics, the research shows that the energy released from dark matter decay could alter the chemistry of early galaxies enough to cause some of them to directly collapse into black holes rather than forming stars.

The result is timely, since NASA’s James Webb Space Telescope continues to observe unusually large black holes in the early universe that could have formed by direct collapse. Astronomers had believed this process requires a coincidence of nearby stars shining onto pre-stellar gas and so expected it to be rare.

Aggarwal’s team goes beyond the standard approach by using dark matter—the unknown 85% of the matter in the universe that helps form galaxies. They show that if dark matter decays, it can leak a small amount of its energy into the gas and supercharge the direct collapse rate. Each decaying dark matter particle would only need to inject an amount of energy that is a billion trillionths of the energy of a single AA battery.

Scientists Just Took A Major Step Towards One Of Sci-Fi’s Biggest Tropes

Major milestone in the viability of cryonic suspension in the form of revival of cells after vitrification. Vitrification is basically the use of chemical fixation at ultra cold temperatures, kinda like antifreeze. It prevents ice crystals forming in your cells, preventing them from being torn apart.

It’s INSANELY toxic, so solving that problem would mean we can really revive people in suspension who underwent vitrification (which is standard practice at ALCOR for a long time now).

That said, we still will need ways to repair whatever disease or injury that the patient actually died from. 😁👍

Researchers in Germany have developed a technique to vitrify mouse brain tissue and then thaw it out, all without significant loss of function.

Implantable islet cells could control diabetes without insulin injections

Most diabetes patients must carefully monitor their blood sugar levels and inject insulin multiple times per day, to help keep their blood sugar from getting too high. As a possible alternative to those injections, MIT researchers are developing an implantable device that contains insulin-producing cells. The device encapsulates the cells, protecting them from immune rejection, and it also carries an onboard oxygen generator to keep the cells healthy.

This device, the researchers hope, could offer a way to achieve long-term control of type 1 diabetes. In a new study, they showed that these encapsulated pancreatic islet cells could survive in the body for at least 90 days. In mice that received the implants, the cells remained functional and produced enough insulin to control the animals’ blood sugar levels.

“Islet cell therapy can be a transformative treatment for patients. However, current methods also require immune suppression, which for some people can be really debilitating,” says Daniel Anderson, a professor in MIT’s Department of Chemical Engineering and a member of MIT’s Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science. “Our goal is to find a way to give patients the benefit of cell therapy without the need for immune suppression.”

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