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Category: chemistry – Page 3

Development of revolutionizing photo-induced microscopy and its use around the globe celebrated in new publication

Photo-induced force microscopy began as a concept in the mind of Kumar Wickramasinghe when he was employed by IBM in the early years of the new millennium. After he came to the University of California, Irvine in 2006, the concept evolved into an invention that would revolutionize research by enabling scientists to study the fundamental characteristics of matter at nanoscale resolution.

Since the earliest experimental uses of PiFM around 2010, the device, which reveals the chemical composition and spatial organization of materials at the , has become a tool of choice for researchers in fields as diverse as biology, geology, materials science and even advanced electronics manufacturing.

“This is the story of a technology that was inspired by work at IBM, was invented and developed at UC Irvine, then got spun off, and now we have instruments on all continents across the world except for Antarctica,” says Wickramasinghe, Henry Samueli Endowed Chair and Distinguished Professor emeritus of electrical engineering and computer science who now holds the title of UC Irvine Distinguished Research Professor. “Almost anywhere serious research is happening, there are people out there who are using PiFM to discover new things.”

Successful synthesis of neutral N₆ opens door for future energy storage

Nitrogen finally joins the elite tier of elements like carbon that can form neutral allotropes—different structural forms of a single chemical element. Researchers from Justus Liebig University, Giessen, Germany, have synthesized neutral hexanitrogen (N6)—the first neutral allotrope of nitrogen since the discovery of naturally occurring dinitrogen (N2) in the 18th century that is cryogenically stable and can be prepared at room temperature.

This new study, published in Nature, synthesized hexanitrogen (N6) via gas-phase reaction, with the main ingredients being chlorine (Cl2) or bromine (Br2) and an extremely reactive and explosive solid silver azide (AgN3), under reduced pressure.

The researchers spread AgN3 on the , and a gaseous halogen (Cl2 or Br2) was passed through the solid under reduced pressure at room temperature. The reaction triggered by the process produced N6 alongside byproducts chloronitrene (ClN) and hydrazoic acid (HN3).

Successful experiments reprogram rogue T cells for targeted autoimmune disease therapy

Two teams of researchers have developed a cell reprogramming technology that converts rogue disease-causing T cells from our immune system into protective Treg cells. These cells help ensure that the immune system doesn’t attack the body’s own tissues. The breakthroughs could usher in more personalized and targeted cell therapies for a host of autoimmune diseases.

In the first paper, published in the journal Science Translational Medicine, scientists developed a targeted cell therapy against pemphigus vulgaris (PV). This severe autoimmune skin disease causes blisters and sores.

They took the cells that were causing the disease (Dsg3-specific pathogenic T cells) from mouse models and and converted them into harmless Treg cells. They used specialized chemical tools to switch on a gene called Foxp3, which controls a cell’s ability to help the , and cut off a specific activation signal to prevent the cells from turning back into attackers.

Hydrogen atom

A hydrogen atom is an atom of the chemical element hydrogen. The electrically neutral hydrogen atom contains a single positively charged proton in the nucleus, and a single negatively charged electron bound to the nucleus by the Coulomb force. Atomic hydrogen constitutes about 75% of the baryonic mass of the universe. [ 1 ]

In everyday life on Earth, isolated hydrogen atoms (called “atomic hydrogen”) are extremely rare. Instead, a hydrogen atom tends to combine with other atoms in compounds, or with another hydrogen atom to form ordinary (diatomic) hydrogen gas, H2. “Atomic hydrogen” and “hydrogen atom” in ordinary English use have overlapping, yet distinct, meanings. For example, a water molecule contains two hydrogen atoms, but does not contain atomic hydrogen (which would refer to isolated hydrogen atoms).

Atomic spectroscopy shows that there is a discrete infinite set of states in which a hydrogen (or any) atom can exist, contrary to the predictions of classical physics. Attempts to develop a theoretical understanding of the states of the hydrogen atom have been important to the history of quantum mechanics, since all other atoms can be roughly understood by knowing in detail about this simplest atomic structure.

Geochemical research could help identify microbial activity in Earth’s rock record and perhaps in Martian sediments

Because oxygen-bearing sulfate minerals trap and preserve signals from Earth’s atmosphere, scientists closely study how they form. Sulfates are stable over billions of years, so their oxygen isotopes are seen as a time capsule, reflecting atmospheric conditions while they were evolving on early Earth—and possibly on its planetary neighbor Mars.

A new study led by a University of Utah geochemist examines how forms when pyrite, commonly known as “fool’s gold,” is oxidized in environments teeming with microbes versus those without them. The researchers focused on Spain’s Rio Tinto, a contaminated river passing through a region where iron and copper were mined for thousands of years.

The paper titled, “Triple-oxygen isotopic evidence of prolonged direct bioleaching of pyrite with O2,” appears in Earth and Planetary Science Letters.

A tiny chip that can help us see deeper into space

A new imaging system could help us see deeper into the universe than ever before. The same powerful technology could also help us analyze the chemical makeup of everyday materials such as food and medicines much faster and with greater accuracy than current methods.

In a study published in the journal Nature, researchers from Tsinghua University in China have introduced a tiny device called RAFAEL (Reconfigurable, Adaptive, FAst and Efficient Lithium-niobate spectro-imager) that uses advanced photonics to capture light in exceptional detail with high speed.

RAFAEL is designed to dramatically improve spectroscopy, the technique used to study the and chemical composition of matter. It is used for everything from mapping to checking for contaminants in water and diagnosing diseases, and it works by breaking down the light that comes from an object and analyzing the different colors (wavelengths). While incredibly powerful, traditional spectrometers often face a trade-off: To get very fine detail you have to block much of the light. Or if you let in a lot of light, you lose resolution or sensitivity.

Microscopic DNA ‘Flowers’ Could Transform Targeted Drug Delivery

Researchers at the University of North Carolina (UNC) have developed microscopic flower-shaped soft robots made from DNA and inorganic materials that can fold, bend, and react to their environment. Detailed in a paper published in Nature Nanotechnology, these microscopic DNA “flowers” are a potential new method for targeted drug delivery and other biomedical applications.

“People would love to have smart capsules that would automatically activate medication when it detects disease and stops when it is healed. In principle, this could be possible with our shapeshifting materials,” said senior author Ronit Freeman, PhD, and associate professor at USC and leader of a research group that is seeking to develop novel designer materials using self-assembling biological components.

The DNA flowers are assembled from hybrid DNA, inorganic crystals that respond to environmental stimuli such as changes in acidity (pH), enabling reversible changes in shape—shrinking, bending, and folding—within seconds. The petals can open or close in response to local environmental conditions, motion that can be used to trigger a chemical reaction, release molecules, or interact with tissues.

New telescope opens window to southern sky

A powerful new telescope has captured its first glimpse of the cosmos, and could transform our understanding of how stars, galaxies and black holes evolve.

The 4MOST (4-meter Multi-Object Spectroscopic Telescope), mounted on the European Southern Observatory’s VISTA telescope in Chile, achieved its ‘first light’ on 18 October 2025: a milestone marking the start of its scientific mission.

Unlike a typical telescope that takes pictures of the sky, 4MOST records spectra—the detailed colors of light from —revealing their temperature, motion and chemical makeup. Using 2,436 optical fibers, each thinner than a human hair, the telescope can study thousands of stars and galaxies at once, splitting their light into 18,000 distinct color components.

Red light and recyclable catalysts drive sustainable photocatalysis

Modern chemistry is increasingly focused on developing sustainable processes that reduce energy consumption and minimize waste. Photocatalysis, which uses light to promote chemical reactions, offers a promising alternative to more aggressive conventional methods. However, most existing photocatalysts are homogeneous—they dissolve in the reaction medium and cannot be easily recovered or reused—and they typically rely on blue or ultraviolet light, which is more energy-demanding and penetrates poorly into reaction mixtures, limiting their large-scale and biological applications.

Researchers at the Center for Research in Biological Chemistry and Molecular Materials (CiQUS) have developed an innovative, more sustainable method that uses red light—a low-energy, deeply penetrating —together with recyclable solid catalysts to promote cleanly and efficiently. The study highlights the potential of covalent organic frameworks (COFs) as red-light-active heterogeneous photocatalysts, a field that remains largely unexplored. This combination of reusable materials and mild light represents a significant step toward greener chemical methodologies.

The work is published in the Journal of the American Chemical Society.

Shanghai Tower serves as inspiration for first synthetic dynamic helical polymer

Researchers at the University of Groningen in the Netherlands have developed a polymer that adopts a coiled spring configuration at low temperatures and unfolds again upon heating. Furthermore, the molecule can break down into smaller molecules under certain conditions. The Shanghai Tower, with its spiral shape, served as the inspiration for the project following a visit five years ago. A description of the resulting helical polymer was recently published in Nature Chemistry.

Spiraling structures are common in . A well-known example is the double helix of DNA; another is the alpha-helix domains in proteins. Various artificial helices have been created, some of which can change their shape. Other can be recycled into their monomers, but so far, no polymers have been developed that can both change shape and be recycled into their .

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