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Navigating Postacute Care Options for Patients After Hospital Discharge: A Review

Approximately 25% to 40% of hospitalized adults are discharged to receive postacute care either at home through home health or in skilled nursing facilities, inpatient rehabilitation facilities, or long-term acute care hospitals.

This Narrative Review considers postacute care settings to assist hospital-based clinicians in effectively collaborating with patients, caregivers, and interdisciplinary care teams to facilitate transitions to high-quality postacute care.


Clinicians often care for patients who cannot return to their previous level of support in the community due to new functional impairments or complex posthospital care needs. After hospital discharge, these patients may require postacute care (PAC)—broadly defined as medical and rehabilitative services intended to help individuals recuperate and rehabilitate. PAC can be provided at home through home health (HH) or in skilled nursing facilities (SNFs), inpatient rehabilitation facilities (IRFs), and long-term acute care hospitals (LTACHs). A key criterion for PAC eligibility is the need for skilled nursing and/or rehabilitative services as determined by the treating physician.1-3 Payers require that these health services be reasonable and necessary for the treatment of a specific illness or injury, and that given their complexity (eg, wound care, intravenous infusion), they be provided only by a health professional. Yet, clinicians often play a passive role in PAC planning; many report a lack of knowledge around PAC capabilities, quality, and constraints.4-6

The epidemiology of PAC in the US is best understood for Traditional Medicare (or fee-for-service). Among hospitalized Medicare beneficiaries, approximately 40% were discharged to PAC in 2023: 18% to HH, 17% to SNF, 5% to IRFs, and 1% to LTACHs,7 accounting for approximately $60 billion of Medicare spending annually.7 Up to three-quarters of regional differences in Medicare spending are attributable to PAC, suggesting that discharge decisions are often driven by local practice norms rather than patient need. This underscores the need to improve and standardize PAC best practices.8,9

Hospital-based physicians, nurse practitioners, and physician assistants play an important role in PAC discharge planning due to their in-depth understanding of a patient’s complex medical needs. A better understanding of the qualifications and services provided can help clinicians engage in a more helpful role in the PAC discharge planning process. This Narrative Review provides an overview of PAC settings with the goal of helping clinicians collaborate most effectively with patients, caregivers, and interdisciplinary care teams to promote transition to high-quality PAC. We present a general summary of the most common types of PAC, followed by a comparison of the supporting evidence for each PAC setting. Descriptions of elements of PAC are based on the benefits covered by Traditional Medicare, which generally inform other payers’ coverage policies. Lastly, we review best practices for clinicians to actively discuss PAC options with patients, helping to orchestrate transitions of care to PAC for eligible individuals.

Why the “Immortal” Jellyfish Can Age Backwards — And What That Means for Human Aging

A tiny jellyfish found in the ocean possesses an extraordinary ability to reverse its life cycle. This creature can transform from an adult back to a polyp, essentially resetting its biological clock. Scientists are studying its DNA to understand this process. This discovery offers new insights into aging and regeneration, potentially impacting future medical research.

The role of liver sinusoidal endothelial cells in liver diseases: Key players in health and pathology

Liver sinusoidal endothelial cells (LSECs) are specialised endothelial cells that orchestrate hepatic homeostasis within the liver sinusoid. Besides their key role in regulating intrahepatic vascular tone, trafficking and cellular crosstalk, their scavenging and immune-regulatory role makes them central to the development of liver disease. LSEC dysfunction includes loss of fenestrae, inflammatory activation and the gain of vasoconstrictive and prothrombotic functions. Robust evidence has demonstrated how preserving LSECs is crucial in a pathological context, placing LSECs at the centre of novel therapeutic and diagnostic strategies.

Pharmacologic reversal of advanced Alzheimer’s disease in mice and identification of potential therapeutic nodes in human brain

Here, we show that pharmacologic restoration of NAD+ homeostasis via P7C3-A20, a neuroprotective compound that restores NAD+ homeostasis without producing supraphysiologic NAD+ levels,51,52,53,54,55,56 reverses cognitive deficits and neuropathology in advanced Aβ- and tau-driven AD models. We identify conserved molecular signatures between human and mouse AD and show that the magnitude of NAD+ homeostasis disruption correlates with pathology and symptom severity in mouse and human AD. We also demonstrate that NDAN brains display transcriptional profiles compatible with preserved NAD+ homeostasis and that P7C3-A230 restores NAD+ homeostasis and prevents oxidative damage and mitochondrial dysfunction in oxidatively stressed human brain microvascular endothelial cells (HBMVECs), a key component of the BBB. We additionally identify 46 conserved protein alterations in human and mouse AD brain that are corrected by AD reversal, together with overlapping transcriptomic changes in human AD. This highlights potential mechanisms and therapeutic targets for preserving and restoring brain resilience to AD.

These findings of cognitive recovery and pathological reversal in diverse models of advanced AD support disease progression as modifiable and driven by diminished brain resilience, with early cognitive impairment resulting from processes that promote neurodegeneration rather than solely from fixed neuronal loss. We propose that therapies to restore brain resilience, such as normalization of NAD+ homeostasis, merit clinical evaluation for prevention and reversal of AD and related dementias.

Effect of Low-Dose Dobutamine Infusion on N-Terminal Pro–B-Type Natriuretic Peptide in At-Risk Patients With Acute Myocardial Infarction (DOBERMANN-D): A Randomized Clinical Trial

In AMI patients at risk of in-hospital CS development, early dobutamine infusion did not reduce NT-proBNP plasma concentration but reduced SBP with no safety concerns.

JACC CRT2026


The Journal of the American College of Cardiology (JACC) stands as a leading global resource for impactful cardiovascular research, delivering essential peer-reviewed articles and crucial clinical practice guidelines. Gain access to authoritative medical content and vital CME resources designed to advance cardiovascular medicine and improve heart patient outcomes.

Cuffless Devices for the Measurement of Blood Pressure: A Scientific Statement From the American Heart Association

Cuffless BP devices have the potential to increase access and overcome barriers to BP screening, particularly for underresourced communities. Individuals from these communities—including people from rural areas, with low income, or from underrepresented racial or ethnic groups—often have a higher prevalence of hypertension and uncontrolled BP than their counterparts and face barriers to accessing health care services, including regular BP monitoring and confirmation of office BP with ABPM.32–34

One of the primary barriers to BP screening in underresourced communities is a lack of health care facilities and trained physicians.35 Cuffless devices, which are often portable and convenient and can be incorporated into everyday objects (eg, watches, smartphones), can be deployed in homes, in community centers, among lay community health workers, and by individuals themselves.4,5,36 This accessibility eliminates the need for individuals to travel long distances to receive basic health screenings, making it easier for residents of rural areas, or areas with shortages of health care professionals, to monitor their out-of-office BP regularly.

Cost is a major barrier hindering access to health care and traditional BP monitoring methods for individuals from underresourced populations, many of whom may be uninsured or underinsured. Cuffless BP devices could theoretically reduce costs, particularly when integrated into wearable or mobile devices that consumers purchase for multiple uses.36 However, because of the limitations of cuffless devices, including the need for calibration with additional purchased devices and insufficient accuracy, cost-effectiveness remains speculative.

One-hour saliva test spots biomarker linked to several cancers

QUT researchers have developed a simple one-hour saliva test for a protein biomarker that has been linked with oral, colon and pancreatic cancers. The findings are published in the journal Talanta.

The paper is titled “Label free paper sensor and light driven material for the rapid screening of S100P cancer biomarker in saliva.” Corresponding author, Associate Professor Emad Kiriakous, from QUT’s School of Chemistry and Physics, said this technology could pave the way for simple, low-cost, point-of-care screening tools to help identify and treat cancer early.

Professor Kiriakous said the QUT team developed a rapid testing technique of saliva using paper coated in gold and silver nanoparticles to create a highly sensitive sensor that records the Raman spectrum (or SERS, the process by which a substance scatters laser light which is used to identify molecules) of saliva samples.

Myocarditis and look-alikes: when the diagnosis matters

Myocarditis is an inflammatory disease of the heart muscle that can be triggered by various causes, including viruses, autoimmune response, molecular mimicry and exposure to immune-stimulating drugs or vaccines. Most cases of myocarditis heal, and cardiac dysfunction, if present, recovers; however, selected forms may require targeted therapy to improve outcomes. We herein review five conditions presenting with or mimicking myocarditis that require targeted diagnostic approaches, including endomyocardial biopsy, and/or targeted treatments. Giant cell myocarditis is an intense and unresolving inflammation of the heart, characterised by rapid progression, significant arrhythmias, heart failure and shock, that is unlikely to resolve without immunosuppression therapy.

The role of ionizing radiation-initiated reactions in targeted activation of chemotherapeutics

This Review explores how ionizing radiation triggers drug release via water radiolysis, detailing reactive species, drug activation mechanisms and strategies for designing radiation-sensitive prodrugs and nanocarriers to enhance chemoradiation therapy with reduced systemic toxicity.

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