Re-engineered macrophages to treat cancer.
Today we have a new study where researchers have created immune cells that ignore the way cancer tries to hide from detection.
Hiding in plain sight
Continue reading “Re-engineering Macrophages to Eat Cancer Cells” »
Chronological age has been typically used as a way to gauge how someone is aging, however this is a poor measure indeed. People tend to age at different rates due to a variety of reasons, environment, diet, diseases in earlier life, stress, exercise and lifestyle all play a role in how a person ages.
Clearly a better way to measure aging is needed if we are to accurately assess how someone is aging for the purposes of health monitoring and research. One way to do this is to use functional aging as a way to determine how someone is aging.
Functional aging is defined as a combination of the chronological, physiological, mental, and emotional ages of a person that give an overall measure of their rate of aging.
Continue reading “Dr. Elliott Small – AgeMeter The Functional Aging Biomarker System” »
DARPA created the Safe Genes program to gain a fundamental understanding of how gene editing technologies function; devise means to safely, responsibly, and predictably harness them for beneficial ends; and address potential health and security concerns related to their accidental or intentional misuse. Today, DARPA announced awards to seven teams that will pursue that mission, led by: The Broad Institute of MIT and Harvard; Harvard Medical School; Massachusetts General Hospital; Massachusetts Institute of Technology; North Carolina State University; University of California, Berkeley; and University of California, Riverside. DARPA plans to invest $65 million in Safe Genes over the next four years as these teams work to collect empirical data and develop a suite of versatile tools that can be applied independently or in combination to support bio-innovation and combat bio-threats.
Gene editing technologies have captured increasing attention from healthcare professionals, policymakers, and community leaders in recent years for their potential to selectively disable cancerous cells in the body, control populations of disease-spreading mosquitos, and defend native flora and fauna against invasive species, among other uses. The potential national security applications and implications of these technologies are equally profound, including protection of troops against infectious disease, mitigation of threats posed by irresponsible or nefarious use of biological technologies, and enhanced development of new resources derived from synthetic biology, such as novel chemicals, materials, and coatings with useful, unique properties.
Achieving such ambitious goals, however, will require more complete knowledge about how gene editors, and derivative technologies including gene drives, function at various physical and temporal scales under different environmental conditions, across multiple generations of an organism. In parallel, demonstrating the ability to precisely control gene edits, turning them on and off under certain conditions or even reversing their effects entirely, will be paramount to translation of these tools to practical applications. By establishing empirical foundations and removing lingering unknowns through laboratory-based demonstrations, the Safe Genes teams will work to substantially minimize the risks inherent in such powerful tools.
Researchers in the US have reported what they believe is a first-of-its-kind reversal of brain damage, after treating a drowned and resuscitated toddler with a combination of oxygen therapies.
The little girl, whose heart didn’t beat on her own for 2 hours after drowning, showed deep grey matter injury and cerebral atrophy with grey and white matter loss after the incident, and could no longer speak, walk, or respond to voices – but would uncontrollably squirm around and shake her head.
Today Lifespan.io / Life Extension Advocacy Foundation has launched the fifth research project since we began 1.5 years ago. We are working with the Centers for Age Control Inc who plan to develop a multiple aging biomarker system to aid clinical research, healthcare providers and enthusiasts.
For more details check out the press release here: http://www.leafscience.org/introducing-agemeter/
Continue reading “AgeMeter: Physiological Biomarkers to Determine Functional Age” »
Tweaking the types of microglia to favour a healing type over an inflammatory type has been the focus of a number of recent studies. This time the tremedous regenerative ability of zebrafish is the focus of research.
The evidence that the immune system, and in particular the various types of tissue resident macrophages play an important role in the regeneration of tissue continues to mount up.
The difference in the behaviour of these macrophages varies between species and may significantly contribute to the differences in regenerative capacity observed between slow regenerative species like mice and humans and species capable of robust rejuvenation such as salamanders and zebrafish. The latter two species being able to regenerate lost limbs and organs and the former two being far more limited.
Continue reading “Altering Microglia Types to Combat Degenerative Eye Diseases” »
Electric fields can be used to guide transplanted human neural stem cells — cells that can develop into various brain tissues — to repair brain damage in specific areas of the brain, scientists at the University of California, Davis have discovered.
It’s well known that electric fields can locally guide wound healing. Damaged tissues generate weak electric fields, and research by UC Davis Professor Min Zhao at the School of Medicine’s Institute for Regenerative Cures has previously shown how these electric fields can attract cells into wounds to heal them.
Continue reading “Neural stem cells steered by electric fields can repair brain damage” »
“Microglia play an important role in Alzheimer’s and other diseases of the central nervous system. Recent research has revealed that newly discovered Alzheimer’s-risk genes influence microglia behavior,” Jones said in an interview for a UCI press release. “Using these cells, we can understand the biology of these genes and test potential new therapies.”
A Renewable Method
Continue reading “A New Technique Transforms Human Skin Into Brain Cells” »
