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Monkeys navigate a virtual forest with thought alone, pushing brain-computer interfaces beyond the lab

As a part of a study testing out a new type of implanted brain-computer interface (BCI), three rhesus monkeys controlled movements in a virtual reality (VR) world using only brain signals. The study, published in Science Advances, demonstrates a major step toward practical BCIs that can work outside of lab conditions.

BCIs allow direct communication between the brain and external devices, like a computer or robotic arm. This ability is thought to be extremely valuable for helping people suffering from paralysis to move objects, communicate or complete other tasks. However, there is a gap between lab-based BCI demonstrations and practical, flexible systems for real-world usage.

Previous research has explored intracortical BCIs—those implanted directly into the brain—in monkeys and humans, enabling them to control computer cursors, robotic or prosthetic arms and wheelchairs. Others have restored communication and the function of paralyzed limbs. However, real-world navigation requires adapting to unpredictable events and complex environments, which previous BCIs have struggled with, often requiring overt movement or only working in overly simple settings.

Laser method unlocks 3,000-Kelvin thin-film synthesis for quantum materials

Thin films might not come up in conversation every day, but they are all around us. Take the metallic plastic films of chip bags, for example, or the anti-reflective coatings on eyeglasses. Even the coatings on pills that make them easier to swallow are thin films. Depositing extremely thin layers of materials in a consistent and uniform way is also crucial to the production of semiconductors, which are the foundation of modern electronics.

Not all materials can be easily deposited in such thin layers, such as materials with very high melting points. Now, Caltech researchers led by Austin Minnich, professor of mechanical engineering and applied physics, and deputy chair of the Division of Engineering and Applied Science, have demonstrated a laser-based method for generating thin films of materials, such as niobium. The work could directly impact superconducting electronics used in quantum computers.

The team recently described the work in a paper published in the journal Applied Physics Letters.

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis

Now online! The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: (Cell 188, 4567–4585.e1–e12; August 21, 2025)


Now online! (Cell 188, 4567–4585.e1–e12; August 21, 2025)

During post-publication review of our article, we, the authors, identified several errors in figure assembly and annotation affecting representative images and sample size reporting. These issues are limited to figure presentation and do not affect the underlying data, quantification, or conclusions of the study.

In Figure 2G, incorrect representative images were inadvertently used for the interferon-γ-OE and PSMB8-OE glutamate conditions. The correct images have now been inserted.

Automated Imaging Differentiation for DementiaIncluding Alzheimer Disease Dementia and Dementia With Lewy Bodies

Two most common causes of dementia in older adults are Alzheimer disease dementia (ADD) and dementia with Lewy bodies (DLB).1,2 Differentiating between ADD and DLB in the clinical environment remains challenging with high rates of misdiagnosis using the current standard of care.2 Up to 50% of neuropathologically confirmed DLB, known as Lewy body disease (LBD), are correctly diagnosed antemortem, with ADD as the most common misdiagnosis.2,3 Distinguishing DLB from ADD is a vital part of patient care as DLB has a worse prognosis and requires different treatment plans compared with ADD.4 Patients with DLB are particularly sensitive to neuroleptics prescribed in dementia care, leading to worsening cognitive and motor functions.5 Further, new disease-modifying therapies are approved for ADD, but not for DLB.6,7

The National Institute on Aging and Alzheimer’s Association developed a research framework for Alzheimer disease (AD) classification using biomarkers such as amyloid, tau, and neurodegeneration.8 Amyloid positivity, as assessed using PET or biofluid assays (e.g., AB42/40, ptau217), is a core pathologic, distinguishing feature of AD. However, amyloid and Lewy body copathologies occur in over 50% of patients with LBD and can contribute to diagnostic uncertainty.2,9,10 In lieu of a DLB biomarker classification framework, current diagnostic criteria recommend combining indicative and supportive biomarkers to improve distinguishing between DLB and ADD. Indicative biomarkers include dopamine transporter scans (DaTscan), myocardial scintigraphy, and polysomnography. Supportive biomarkers are collected using MRI, PET, or SPECT scans, and EEG. Current MRI biomarkers in DLB leverage the relative sparing of the medial temporal lobe (MTL) to aid in differentiation.

Fat cells steer flies away from pathogen-tainted food through a newly revealed neural circuit

If humans or animals eat something that causes them to feel unwell, they subsequently avoid this food source. Until now, it has been unclear precisely how this avoidance learning takes place. A new study shows that communication between the brain cells and fat cells could play a crucial role here. The participants from the Universities of Bonn and Tohoku (Japan) and University Hospital Bonn have revealed the previously unknown mechanism in the fruit fly Drosophila. It may also exist in a similar form in mammals and even in humans. The results have now been published in the journal Neuron.

Anyone who’s ever had an upset stomach after eating a bad meatball knows just how much this experience can put you off them. Within research, this is also known as “conditioned taste aversion”: The brain registers the immune response to the bacteria and their toxins and concludes from this that the food source should be avoided in the future.

It is not yet known how the immune system’s discovery of the pathogens leads to a change in behavior. “As this learned food avoidance can be found in all species, we investigated this question in a model organism – the fruit fly Drosophila,” explains Prof. Dr. Ilona Grunwald Kadow. “Within this model, we can clarify how the brain and body interact with each other to trigger an avoidance reaction that is vital for survival.”

Phage Therapy Gains Momentum in Antibiotic Resistance

As antimicrobial resistance continues to challenge traditional treatment protocols, bacteriophage therapy is emerging as a viable precision medicine alternative. Recent clinical developments demonstrate the potential of these virus-based interventions to target multi-drug resistant pathogens while preserving the host microbiome.


Growing antimicrobial resistance is prompting renewed interest in phage therapy, with preliminary data indicating improved outcomes when combined with standard antibiotics.

Fat-producing enzyme may amplify damage in Parkinson’s disease

As the flies aged, they developed Parkinson’s-like symptoms – including impaired movement and loss of brain cells – mirroring key aspects of disease progression seen in humans.

Using large-scale genetic screening made possible by the fruit fly model, the researchers systematically identified genes involved in α-synuclein-induced toxicity. Among these, the gene mino stood out for its strong effects on disease-related symptoms, leading the team to investigate its role further. This gene codes for the enzyme glycerol-3-phosphate acyltransferase (GPAT) and plays a key role in regulating fat metabolism in cells.

When the scientists reduced the activity of the mino gene, the flies experienced less loss of brain cells, improved movement, and healthier activity patterns. In contrast, increasing the gene’s activity worsened the flies’ symptoms.

The researchers then explored whether blocking GPAT could help counter these toxic effects. They tested a compound called FSG67, which blocks the activity of GPAT and has previously been studied in laboratory settings for obesity-related and metabolic disorders.

When the flies were treated with FSG67, the harmful effects of α-synuclein – including protein clumping and fat damage – were reduced. The scientists observed similar protective effects in mouse brain cells grown in the laboratory.

Going forward, the scientists will focus on further validating these findings and exploring the possibility of developing GPAT inhibitors as a new class of drugs for Parkinson’s disease. ScienceMission sciencenewshighlights.


3 Interventions to Show Aging is Treatable: The US Government’s $38M Bet

The US Government is finally treating aging as a modifiable condition. Discover the VITAL-H trial: a $38M federal study testing Rapamycin, Semaglutide, and Dapagliflozin to set the first FDA-approved roadmap for healthy longevity.
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Is aging finally becoming a recognized medical priority? In this video, we break down the historic VITAL-H trial, a $38 million initiative funded by ARPA-H (the \.

A black licorice compound slashes gut inflammation and cell death in IBD models and animals

A new study published in Stem Cell Reports demonstrates how a human stem cell-derived model of the intestine can be used to identify potential therapies for inflammatory bowel disease (IBD), highlighting glycyrrhizin as a promising candidate for reducing intestinal inflammation and cell death.

The burden of IBD is rising globally, with an estimated 4 million people affected worldwide. The disease is characterized by chronic inflammation of the intestinal wall, leading to symptoms such as persistent diarrhea, abdominal pain, and fatigue. Standard treatments include anti-inflammatory drugs and other immune-targeting therapies, but many patients experience only limited benefit.

High-throughput screening (HTS) offers a promising strategy to discover new IBD therapies but depends on having a reliable model of the human intestinal wall for laboratory testing.

A transcriptional atlas of the pubertal human growth plate reveals two populations of stem cells and direct effect of growth hormone

This study reveals two populations of cartilage stem cells in both human and mouse growth plates, reshaping our understanding of longitudinal growth.

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