Lifeboat Foundation

In 2015, European countries formulated the Sustainable Development Goals (SDG), which aimed to end TB by 2030. However, in September 2018, global leaders at the first United Nations (UN) General Assembly High-Level Meeting on the Fight Against TB agreed on an ambitious target of eradicating TB by 2022. They strategized that increased access to TB treatment and preventive measures would help achieve their goal quickly. Another measure adopted to progress the TB eradication goal was increasing the funds related to TB research and services.

An uneven progress regarding TB eradication by 2030 was observed in some European regions by the World Health Organization (WHO). Although the majority of Western European countries were on track for TB elimination, Eastern European and Central Asian countries reported a high number of incidences of drug-resistant (DR) TB.

In the European Union/European Economic Area (EU/EEA), TB prevalence is low. Based on the TB surveillance conducted in Europe, out of 30 countries, 24 reported less than 10 TB cases per 100,000 population in 2021. These countries have been encouraged to maintain this low rate and attain the pre-elimination phase of less than 10 TB cases per million population per year. A recent Eurosurveillance journal editorial discussed the progress in the EU/EEA, between 2018 and 2021, towards achieving the 2030 targets for TB elimination.

Continue reading “How can Europe tackle its unfinished tuberculosis business?” »

Summary: Using a new technology called The Virtual Brain, researchers are able to create personalized computerized brain models of individual patients based on their anatomy, structural connectivity, and brain dynamics.

Source: Human Brain Project.

In the current edition of The Lancet Neurology, researchers of the Human Brain Project (HBP) present the novel clinical uses of advanced brain modeling methods.

“People study cells in the context of their biology and biochemistry, but cells are also simply physical objects you can touch and feel,” Guo says. “Just like when we construct a house, we use different materials to have different properties. A similar rule must apply to cells when forming tissues and organs. But really, not much is known about this process.”

His work in cell mechanics led him to MIT, where he recently received tenure and is the Class of ’54 Career Development Associate Professor in the Department of Mechanical Engineering.

At MIT, Guo and his students are developing tools to carefully poke and prod cells, and observe how their physical form influences the growth of a tissue, organism, or disease such as cancer. His research bridges multiple fields, including cell biology, physics, and mechanical engineering, and he is working to apply the insights from cell mechanics to engineer materials for biomedical applications, such as therapies to halt the growth and spread of diseased and cancerous cells.

Prof. Madeline A. Lancaster (MRC Laboratory of Molecular Biology Cambridge, UK) on “Modeling human brain development in cerebral organoids”, at the FENS-SfN Summer School 2018 on Neural stem cells, brain organoids and brain repair, which was held on 3–9 June 2018 in Bertinoro, Italy.

“Introducing the first soft material that can maintain a high enough electrical conductivity to support power hungry devices.” and self-healing.

The newest development in softbotics will have a transformative impact on robotics, electronics, and medicine. Carmel Majidi has engineered a soft material with metal-like conductivity and self-healing properties that, for the first time, can support power-hungry devices.

Continue reading “Engineering breakthrough in softbotics” »

Could a puff of air one day replace the needle in delivering medicines and vaccines? These scientists are working on it.

A new CRISPR tool corrected a genetic mutation that causes vision loss, in an experiment in mice — and its creators at the Wuhan University of Science and Technology (WUST) in China think it could be a safe way to treat countless other genetic diseases in people.

The challenge: Vision starts with light entering the eye and traveling to the retina. There, light-sensitive cells, called photoreceptors, convert light into electrical signals that are sent to the brain.

Retinitis pigmentosa is a rare — and, currently, incurable — genetic disease that can be caused by mutations in more than 100 different genes. These mutations destroy the cells of the retina, leading to vision loss, and for most people, there’s no way to stop the disease or reverse its damage (the exception is a gene therapy approved to treat mutations in the RPE65 gene).

Neuroscientist Sergiu P. Pasca has made it his life’s work to understand how the human brain builds itself — and what makes it susceptible to disease. In a mind-blowing talk laden with breakthrough science, he shows how his team figured out how to grow “organoids” and what they call brain “assembloids” — self-organizing clumps of neural tissue derived from stem cells that have shown the ability to form circuits — and explains how these miniature parts of the nervous system are bringing us closer to demystifying the brain.

If you love watching TED Talks like this one, become a TED Member to support our mission of spreading ideas: http://ted.com/membership.

Continue reading “How We’re Reverse Engineering the Human Brain in the Lab | Sergiu P. Pasca | TED” »

In a recent study published in the journal Cell, researchers describe recent advancements in breast cancer research and how these findings have improved the precise diagnosis of tumor subtypes and contributed to the discovery of novel drug targets for future therapeutics.

Study: Deciphering breast cancer: from biology to the clinic. Image Credit: ORION PRODUCTION / Shutterstock.com