Seeing sick-looking faces in virtual reality triggers brain circuit changes related to threat detection and boosts activity of certain immune cells.
Category: biotech/medical – Page 6
RNA-seq outperforms DNA methods in detecting actionable cancer mutations
Hospital for Sick Children in Toronto researchers are reporting that targeted RNA sequencing can detect clinically actionable alterations in 87% of tumors and provide decisive findings where DNA-seq either fails, returns no variant, or is not informative.
Cancer treatments have seen tremendous improvements in recent years, in part due to highly specific targeting and diagnostic techniques.
DNA-based methods dominate molecular cancer diagnostics but struggle to detect gene fusions and assess splice site consequences. RNA sequencing enables sensitive fusion detection and direct assessment of transcript-level disruption caused by splicing mutations.
Scientists grow novel ‘whole-brain’ organoid
Johns Hopkins University researchers have grown a novel whole-brain organoid, complete with neural tissues and rudimentary blood vessels—an advance that could usher in a new era of research into neuropsychiatric disorders such as autism.
“We’ve made the next generation of brain organoids,” said senior author Annie Kathuria, an assistant professor in JHU’s Department of Biomedical Engineering who studies brain development and neuropsychiatric disorders. “Most brain organoids that you see in papers are one brain region, like the cortex or the hindbrain or midbrain. We’ve grown a rudimentary whole-brain organoid; we call it the multi-region brain organoid (MRBO).”
The research, published in Advanced Science, marks one of the first times scientists have been able to generate an organoid with tissues from each region of the brain connected and acting in concert. Having a human cell-based model of the brain will open possibilities for studying schizophrenia, autism, and other neurological diseases that affect the whole brain—work that typically is conducted in animal models.
Study finds cancer cells boost energy to survive mechanical stress and DNA damage
Cancer cells mount an instant, energy‑rich response to being physically squeezed, according to a study published in the journal Nature Communications. The surge of energy is the first reported instance of a defensive mechanism that helps cells repair DNA damage and survive the crowded environments of the human body.
The findings help explain how cancer cells survive complex mechanical gauntlets like crawling through a tumor microenvironment, sliding into porous blood vessels or enduring the battering of the bloodstream. The discovery of the mechanism can lead to new strategies that pin cancer cells down before they spread.
Researchers at the Center for Genomic Regulation (CRG) in Barcelona made the discovery using a specialized microscope that can compress living cells to just three microns wide, about one‑thirtieth the diameter of a human hair. They observed that within seconds of being squeezed, mitochondria in HeLA cells race to the surface of the nucleus and pump in extra ATP, the molecular energy source of cells.
Augmenting precision medicine via targeted RNA-Seq detection of expressed mutations
Li, D., Li, J., Johann, D.J. et al. Augmenting precision medicine via targeted RNA-Seq detection of expressed mutations. npj Precis. Onc. 9, 182 (2025). https://doi.org/10.1038/s41698-025-00993-8
Researchers make key gains in unlocking the promise of compact X-ray free-electron lasers
New research by scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab), in collaboration with scientists from TAU Systems Inc., has brought the promise of smaller and more affordable X-ray free-electron lasers one step closer to reality.
X-ray free-electron lasers (XFELs) are powerful light sources and are typically large research instruments. Scientists use them to probe nature’s secrets at the atomic level, enabling advances in medicine, biology, physics, materials, and more. The push to develop more compact and less expensive XFELs is expected to increase the number of facilities that will be able to implement this technology, greatly expanding its impact across many areas of science.
“As part of this effort, we are applying our long-standing expertise in a type of advanced accelerator called laser plasma acceleration to shrink XFELs,” said Sam Barber, a staff scientist in Berkeley Lab’s Accelerator Technology & Applied Physics (ATAP) Division. “In addition to standalone light sources, exceptionally high-quality electron beams from plasma accelerators could be injected into existing XFELs to significantly extend their performance.”