Crossing the blood–brain barrier in primates is a major obstacle to gene delivery in the brain. Here an adeno-associated virus variant (AAV.CAP-Mac) is identified and demonstrated for crossing the blood–brain barrier and delivering gene sequences to the brain of different non-human primates species.
A study in mice by Northwestern Medicine researchers has now identified a critical difference in how immune system macrophages help repair the heart in newborns versus adults after a heart attack. They found that in newborns, macrophages perform a process called efferocytosis, which recognizes and eats dying cells. This process triggers the production of a bioactive lipid called thromboxane, signaling nearby heart muscle cells to divide, and allowing the heart to regenerate damaged heart muscle. In contrast, efferocytosis by adult macrophages ultimately culminates in fibrotic scarring.
The study highlights a fundamental difference in how the immune system drives healing based on age and could point to strategies for improving tissue repair after heart attack in adults.
“Understanding why newborns can regenerate their hearts while adults cannot will open the door to developing treatments that could ‘reprogram’ adult macrophages,” said first and co-corresponding author Connor Lantz, PhD, lead scientist of the bioinformatics core at the Comprehensive Transplant Center at Northwestern University Feinberg School of Medicine.
A new understanding of our relationship with our ‘friendly’ gut microbes shows they actually have a dark side and help cause ageing. Here’s how to fight back.
Nanozymes are a class of nanomaterials that exhibit catalytic functions analogous to those of natural enzymes. They demonstrate considerable promise in the biomedical field, particularly in the treatment of bone infections, due to their distinctive physicochemical properties and adjustable catalytic activities. Bone infections (e.g., periprosthetic infections and osteomyelitis) are infections that are challenging to treat clinically. Traditional treatments often encounter issues related to drug resistance and suboptimal anti-infection outcomes. The advent of nanozymes has brought with it a new avenue of hope for the treatment of bone infections.
David Furman, an immunologist and data scientist at the Buck Institute for Research on Aging and Stanford University, uses artificial intelligence to parse big data to identify interventions for healthy aging.
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David Furman uses computational power, collaborations, and cosmic inspiration to tease apart the role of the immune system in aging.
01:06 How much is a Tesla Cybercab?
11:22 How have the features and upgrades of the Tesla Cybercab been enhanced?
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What do you think of a car that can drive itself from the factory straight to your home? A car that will automatically head to the police station if someone tries to steal it or take you to the hospital if you lose consciousness while driving. Or simply, it allows you to enjoy a deep, restful sleep after work and wake up right at your doorstep.
Recently, Elon Musk and his team confidently announced that this vehicle would be available to consumers at just one-fifth the ticket price of Waymo, an incredible deal for two passengers! And you can rest assured about safety, as it has been verified to be 8.5 times safer than a traditional human-driven car.
In today’s episode, we’ll compile all the latest updates on its performance, impressive specifications, final pricing, and a detailed breakdown of its production process, all packed into this 19 minutes. Welcome to Tesla Car World!
As Tesla said the new Cybercab could cost Tesla only half as much to manufacture as a Model Y. This means ticket prices could be significantly lower compared to Waymo, which charges nearly five times the price of a Robotaxi and incurs much higher operating costs due to extensive mapping requirements. This presents a massive profit opportunity for Tesla while offering an incredibly affordable fare for up to two passengers!
Moreover, for the price of a bus ticket—which isn’t always the most pleasant experience—you get a private space, your own cabin. You can relax, sleep, work, entertain yourself, watch a great movie, and travel in the most comfortable and efficient way possible aboard Tesla’s Cybercab.
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#888999evs #teslacarworld #teslacar #888999 #teslarobotaxi #cybercab #teslacybercab.
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“ tabindex=”0” KAIST researchers have discovered a molecular switch that can revert cancer cells back to normal by capturing the critical transition state before full cancer development. Using a computational gene network model based on single-cell RNA
Ribonucleic acid (RNA) is a polymeric molecule similar to DNA that is essential in various biological roles in coding, decoding, regulation and expression of genes. Both are nucleic acids, but unlike DNA, RNA is single-stranded. An RNA strand has a backbone made of alternating sugar (ribose) and phosphate groups. Attached to each sugar is one of four bases—adenine (A), uracil (U), cytosine ©, or guanine (G). Different types of RNA exist in the cell: messenger RNA (mRNA), ribosomal RNA (rRNA), and transfer RNA (tRNA).
This Collection invites multidisciplinary groups to submit their research in Generative Artificial Intelligence for aging research and drug discovery.
Every year, more than 5 million people in the USA are diagnosed with heart valve disease, but this condition has no effective long-term treatment. When a person’s heart valve is severely damaged by a birth defect, lifestyle, or aging, blood flow is disrupted. If left untreated, there can be fatal complications.
Valve replacement and repair are the only methods of managing severe valvular heart disease, but both often require repeated surgeries that are expensive, disruptive, and life-threatening. Most replacement valves are made of animal tissue and last up to 10 or 15 years before they must be replaced. For pediatric patients, solutions are extremely limited and can require multiple reinterventions.
Now, Georgia Tech researchers have created a 3D-printed heart valve made of bioresorbable materials and designed to fit an individual patient’s unique anatomy. Once implanted, the valves will be absorbed by the body and replaced by new tissue that will perform the function that the device once served.
