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The Man Who Proved We Can’t Control AI (And What That Means for Humanity) | Roman Yampolskiy

Dr. Roman Yampolskiy joins me to explore one of the most urgent and uncomfortable questions of our time: what happens when we create intelligence that surpasses our own? We unpack the difference between the AI tools we use today and the emergence of artificial general intelligence, and why the transition from narrow systems to self-improving intelligence may mark a point where human control is no longer possible. Roman shares why even the people building these systems do not fully understand how they work, and why that gap in understanding becomes exponentially more dangerous as capabilities increase.

In this conversation, we explore the limits of control, prediction, and safety in a world where intelligence can recursively improve itself beyond human comprehension. Roman lays out why the problem of AI alignment may be fundamentally unsolvable, what timelines experts are realistically considering, and why even a single mistake at that level could have irreversible consequences. This episode invites a deeper reflection on what we are creating, what we assume we can control, and whether humanity is prepared for the intelligence it is bringing into existence.

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André’s Book Recs: https://www.knowthyselfpodcast.com/bo… 00:00 Intro 01:25 What Is AGI and Why Should We Be Scared? 05:17 Roman’s Journey: From Optimism to Impossibility 09:07 The High Risk, Zero Reward Equation 13:01 Why Superintelligence Is Uncontrollable, Unexplainable, and Unverifiable 18:00 How Long Do We Have? The AGI Timeline 21:24 How Superintelligence Could Actually Kill Us 23:28 Are We Living in a Simulation? 28:21 Can AI Become Conscious? 31:28 Ad: BiOptimizers 32:41 The Possible Timelines: Terminator, the Matrix, or the Zoo 42:24 I-Risk, X-Risk, and S-Risk: Three Ways It Goes Wrong 46:31 The Human Meaning Crisis: Jobs, Purpose, and What’s Left 49:02 Ad: Based Bodyworks 50:20 What Empowers Us as Individuals Right Now 59:37 The Race to Doom: Who’s Building It and Why They Won’t Stop 1:07:41 Can AI Be Conscious — and Does It Already Have Internal Experiences? 1:12:41 Hacking the Simulation: Quantum, DMT, and Escaping the Code 1:18:30 Simulation Theory, Religion, and the Same Ancient Map 1:29:34 The Deal Roman Would Offer Altman, Dario, and Elon 1:39:44 What Is Humor? A Computer Scientist’s Theory 1:43:03 What Comes After: Singularity, Death, and Knowing Thyself ___________ Episode Resources: https://www.romanyampolskiy.com/ https://www.amazon.com/Unexplainable-?tag=lifeboatfound-20 / andreduqum / knowthyself / @knowthyselfpodcast https://www.knowthyselfpodcast.com Listen to the show: Spotify: https://spoti.fi/4bZMq9l Apple: https://apple.co/4iATICX

___________ 00:00 Intro 01:25 What Is AGI and Why Should We Be Scared? 05:17 Roman’s Journey: From Optimism to Impossibility 09:07 The High Risk, Zero Reward Equation 13:01 Why Superintelligence Is Uncontrollable, Unexplainable, and Unverifiable 18:00 How Long Do We Have? The AGI Timeline 21:24 How Superintelligence Could Actually Kill Us 23:28 Are We Living in a Simulation? 28:21 Can AI Become Conscious? 31:28 Ad: BiOptimizers 32:41 The Possible Timelines: Terminator, the Matrix, or the Zoo 42:24 I-Risk, X-Risk, and S-Risk: Three Ways It Goes Wrong 46:31 The Human Meaning Crisis: Jobs, Purpose, and What’s Left 49:02 Ad: Based Bodyworks 50:20 What Empowers Us as Individuals Right Now 59:37 The Race to Doom: Who’s Building It and Why They Won’t Stop 1:07:41 Can AI Be Conscious — and Does It Already Have Internal Experiences? 1:12:41 Hacking the Simulation: Quantum, DMT, and Escaping the Code 1:18:30 Simulation Theory, Religion, and the Same Ancient Map 1:29:34 The Deal Roman Would Offer Altman, Dario, and Elon 1:39:44 What Is Humor? A Computer Scientist’s Theory 1:43:03 What Comes After: Singularity, Death, and Knowing Thyself ___________.

Jacque Fresco: Apply the Methods of Science to the Social System!

I have to confess something about this interview.

I really liked Jacque Fresco. Not as a thinker I was supposed to admire, but as a person: the humor, the humility, the scientific curiosity still burning at 97.

That made the disagreements harder, not easier.

Fresco spent almost a century arguing one idea. We apply the methods of #science to engineering, to medicine, to flight. Then we run our economies and our politics on opinion, tradition, and the preferences of the financial elite.

He thought we had it exactly inverted. Rigor for the machines, guesswork for the humans.

“Technology was never the hard part. The harder question is what kind of society we want it to serve.”

Why I Quit ChatGPT and Switched to Claude

“AI will most likely lead to the end of the world, but in the meantime there will be great companies created.” — Sam Altman, OpenAI CEO

I used to think that was dark humor.

This week, I stopped laughing — and cancelled my ChatGPT subscription.

Not because of the technology. Because of the values.

On February 27, Anthropic refused to give the Pentagon unrestricted access to its AI for mass surveillance and autonomous killer weapons. Within hours, OpenAI’s Sam Altman swooped in and took the deal.

One company held the line. The other sprinted to cross it.

AI helps explain how covert attention works and uncovers new neuron types

Shifting focus on a visual scene without moving our eyes—think driving, or reading a room for the reaction to your joke—is a behavior known as covert attention. We do it all the time, but little is known about its neurophysiological foundation.

Now, using convolutional neural networks (CNNs), UC Santa Barbara researchers Sudhanshu Srivastava, Miguel Eckstein and William Wang have uncovered the underpinnings of covert attention, and in the process, have found new, emergent neuron types, which they confirmed in real life using data from mouse brain studies.

“This is a clear case of AI advancing neuroscience, cognitive sciences and psychology,” said Srivastava, a former graduate student in the lab of Eckstein, now a postdoctoral researcher at UC San Diego.

Why the long interface? AI systems don’t ‘get’ the joke, research reveals

Powerful artificial intelligence (AI) systems, like ChatGPT and Gemini, simulate understanding of comedy wordplay, but never really “get the joke,” a new study suggests.

Researchers wanted to find out whether large language models (LLMs) can understand puns—also known as paronomasia—wordplay that relies on double meanings or sound-alike words, for an intended humorous or rhetorical effect.

While earlier studies suggest LLMs could process this type of humor in a similar way to humans, the team from Cardiff University and Ca’ Foscari University of Venice found AI systems mostly memorize familiar joke structures rather than actually understand them.

Bridging Retinal and Cerebral Neurodegeneration: A Focus on Crosslinks between Alzheimer–Perusini’s Disease and Retinal Dystrophies

In the early stages of Alzheimer–Perusini’s disease (AD), individuals often experience vision-related issues such as color vision impairment, reduced contrast sensitivity, and visual acuity problems. As the disease progresses, there is a connection with glaucoma and age-related macular degeneration (AMD) leading to retinal cell death. The retina’s involvement suggests a link with the hippocampus, where most AD forms start. A thinning of the retinal nerve fiber layer (RNFL) due to the loss of retinal ganglion cells (RGCs) is seen as a potential AD diagnostic marker using electroretinography (ERG) and optical coherence tomography (OCT). Amyloid beta fragments (Aβ), found in the eye’s vitreous and aqueous humor, are also present in the cerebrospinal fluid (CSF) and accumulate in the retina. Aβ is known to cause tau hyperphosphorylation, leading to its buildup in various retinal layers.

Brains and stock markets follow the same rules in crisis, study finds

What do brains and the stock market have in common? While this might sound like a set-up for a joke, new research from U-M researchers reveals that the behaviors of brains and economies during crises can be explained using observations common in the realm of physics. Their work is published in the journal Proceedings of the National Academy of Sciences.

UnCheol Lee, Ph.D. of the U-M Department of Anesthesiology and his collaborative team came up with the idea upon observing that some patients under anesthesia recover faster than others.

“Anesthetic drugs can be considered as introducing a controlled crisis in the brain, interrupting the brain’s network to induce unconsciousness,” explained Lee.

Creepy Science That’s Changing the World in Surprising Ways

From mini-brains and spider-inspired gloves to edible wolf apple coatings and microplastic-filled retinas, scientists are transforming creepy concepts into life-improving innovations. Lab-grown brain organoids could replace animal testing, web-slinging gloves can spin instant wound dressings, and wolf apple starch may keep veggies fresh longer. Meanwhile, the discovery of microplastics in human eyes reveals a haunting truth about our environment’s reach inside us.

Lab-Grown “Mini-Brains” Offer New Insight into the Human Mind

Scientists writing in ACS Sensors have successfully grown a small brain organoid in a petri dish, creating a powerful new tool for studying how nerve cells interact without the use of animal testing. Over two years, human nerve cells multiplied and organized themselves into a three-dimensional “mini-brain” that displayed electrical activity similar to real brain tissue. Researchers say this breakthrough could help scientists better understand how the human brain communicates and functions—or, as they joke, provide “a lab-grown lunch option for zombies.”

The Door That Opens to Another Universe: The True Science Behind SCP-4357 “Slimelord”

What if a simple apartment door in Boston opened into another universe?
SCP-4357, also known as “Slimelord,” is one of the strangest and most human anomalies ever recorded — a hyperspatial discontinuity leading to a world of intelligent slug-like beings with philosophy, humor, and heartbreak.

In this speculative science essay, we explore what SCP-4357 means for physics, biology, and the idea of consciousness itself. How could life evolve intelligence in a sulfur-rich world? Why do these beings mirror human culture so closely? And what happens when curiosity crosses the line into exploitation?

Join us as we break down the science, ethics, and wonder behind one of the SCP Foundation’s most thought-provoking entries.

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🌌 Because somewhere out there, even the slugs have opinions on Kant.

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