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Sep 30, 2022

‘Love Hormone’ Oxytocin Could Mend a Broken Heart

Posted by in categories: biotech/medical, health, sex

Summary: Oxytocin, a hormone connected with bonding and love, could help to heal damage following a heart attack. Researchers found oxytocin stimulates stem cells from the heart’s outer layer and migrates into the middle layer where it develops into muscle cells that generate heart contractions. This could be used to promote the regeneration of heart cells following a heart attack.

Source: Frontiers.

The neurohormone oxytocin is well-known for promoting social bonds and generating pleasurable feelings, for example from art, exercise, or sex. But the hormone has many other functions, such as the regulation of lactation and uterine contractions in females, and the regulation of ejaculation, sperm transport, and testosterone production in males.

Sep 30, 2022

‘Love hormone’ is revealed to have heart healing properties

Posted by in categories: biotech/medical, engineering, health, sex

The neurohormone oxytocin is well-known for promoting social bonds and generating pleasurable feelings, for example from art, exercise, or sex. But the hormone has many other functions, such as the regulation of lactation and uterine contractions in females, and the regulation of ejaculation, sperm transport, and testosterone production in males.

Now, researchers from Michigan State University show that in zebrafish and human cell cultures, oxytocin has yet another unsuspected function: It stimulates derived from the heart’s outer layer (epicardium) to migrate into its middle layer (myocardium) and there develop into cardiomyocytes, that generate heart contractions. This discovery could one day be used to promote the regeneration of the human heart after a . The results are published in Frontiers in Cell and Developmental Biology.

“Here we show that oxytocin, a neuropeptide also known as the love hormone, is capable of activating heart repair mechanisms in injured hearts in zebrafish and human cell cultures, opening the door to potential new therapies for heart regeneration in humans,” said Dr. Aitor Aguirre, an assistant professor at the Department of Biomedical Engineering of Michigan State University, and the study’s senior author.

Sep 29, 2022

Dr. Doris A. Taylor, Ph.D. — CEO, Organamet Bio Inc. — Personalized Bio-Engineered Human Hearts

Posted by in categories: chemistry, engineering, life extension, sex

Personalized Bio-Engineered Human Hearts For All — Dr. Doris A. Taylor, Ph.D., CEO, Organamet Bio Inc.


Dr. Doris A. Taylor, Ph.D. is Chief Executive Officer of Organamet Bio Inc. (https://organametbio.com/) an early phase start-up committed to saving lives and reducing the cost of healthcare for those with heart disease. Organamet has a goal is to make personalized bio-engineered human hearts, available to all who need them, within 5 years, increasing availability and access to hearts, decreasing or eliminating need for immunosuppression, reducing total lifetime transplant costs, and improving quality of life.

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Sep 24, 2022

Space Sex is Serious Business

Posted by in categories: business, sex, space

We’ve done almost no research into this area, but human reproduction in space is going to be key to us living on Mars.

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Sep 24, 2022

Neurophysiological correlates of automatic integration of voice and gender information during grammatical processing

Posted by in categories: neuroscience, sex

Other ERP studies have reported diverse neurophysiological responses to inconsistencies between the message meaning and the speaker’s representation, typically manifest as a modulation of the N400 and/or P600 components15,16,17. Different patterns of ERP results reported in these studies are likely related to the nature of the mismatch manipulations used. For instance, whereas the P600 component is typically associated with a reanalysis/repair of syntactic incongruences and grammatical violations18, in experiments modulating the speaker’s voice it can also be elicited by the violations of the stereotypical noun roles in the absence of grammatical incongruencies as such (e.g., “face powder” or “fight club”, produced by male and female voices, respectively16) as well as the general assumptions based on the pronoun processing during sentence comprehension19. In contrast, the semantically-related N400 effect has been typically found for the semantic-pragmatic incongruences (e.g., “I am going to the night club” by child’s voice17).

Interestingly, these ERP effects offer support to two models of pragmatic language comprehension—the standard, two-step model and the one-step model. The two-step model claims that listeners compute meaning first, in isolation, and that the communicative context is considered at the second stage (speaker’s information, in particular16,20), as reflected in the late P600 responses. More recent findings showed, however, that this pragmatic (extralinguistic) integration is likely happening in a single-step manner already during semantic processing, as reflected in the N400 effect17,21. Nevertheless, other studies also reported the overlap of both processing stages, showing an N400 effect elicited by expectation error and a late P600 effect for overall reanalysis of this expectation22.

Understanding how gender information is integrated by the listeners is particularly important when one considers the differences in how different languages signal grammatical gender. In some languages, such as in English, Finnish or Mandarin, overt grammatical gender marking is almost completely absent. Many other languages, such as Slavic languages, explicitly mark grammatical gender in nouns, verbs, and adjectives, often in a complicated interdependent manner. Russian is one of such languages, offering an optimal testbed for investigating linguistic and extralinguistic gender integration. As far as we know, there is only one study addressing this question in a Slavic language: using Slovak, Hanulíková Carreiras23 found that, during an active-listening task, the integration of speaker-related information and morphosyntactic information occurred rather late during complex sentence processing. Additionally, a conflict between the speaker’s and the word’s genders (e.g., “I– \(stole_{MASC}\) plums” in female voice) was reflected in the modulation of the N400 component. Given that N400/LAN modulations have been consistently found for morphosyntactic violations, in particular for number, person, and gender agreement, as well as in phrase structure violations (e.g.,24, see also for review25), this result may suggest that extralinguistic information is directly integrated during online (morpho)syntactic processing (such as speaker’s sex converted into subject’s gender in (morpho)syntactic processing). However, N400 is also known to be related to conscious top-down controlled integration of linguistic information24,26. Indeed, in the study described above, the participant’s overt attention to the stimuli was required, and the effect generally appeared rather late in the comprehension processes. Thus, the question of whether such findings reflect the involvement of genuine online parsing mechanisms or secondary post-comprehension processes (such as repair and reanalysis24,27) still remains unsolved. Importantly, syntactic parsing has been shown to commence much earlier and to take place in a largely automatic fashion, as demonstrated in studies focused on early left-anterior negativity (ELAN) or syntactic MMN. In particular, ELAN modulation around 200 ms or earlier has been reported during outright violations of the obligatory structure, reflecting an automatic early analysis of the syntactic structure like phrase structure errors28,29,30,31, and it is considered to reflect the brain’s response to the word category violations.

Sep 23, 2022

Friend or Foe? How Mice Decide to Make Love or War

Posted by in categories: neuroscience, sex

Summary: The neural circuitry that connects olfactory information about another mouse’s sex to decision-making in the brain determines the behavioral outcome as to whether aggression or affection is expressed.

Source: CalTech.

Dog owners whose pets meet during a walk are familiar with the immediate sniffing investigation that typically ensues. Initially, the owners cannot tell whether their dogs will wind up fighting, playing, or trying to mount each other. Something is clearly happening in the dog’s brain to make it decide how to behave toward the other dog—but what is going on?

Sep 17, 2022

Weirdest sex tech of the future from metaverse sexual skeletons to VR tongues

Posted by in categories: cyborgs, sex, virtual reality

AS man and machine get ever closer, the world of sex tech seems to get a little stranger.

We’ve rounded up some of the most bizarre sex tech inventions that are in the works, including an exoskeleton could let humans make love in the metaverse.

Humans may rely on exoskeletons to have realistic sex in the metaverse, one sex tech expert has revealed.

Sep 4, 2022

Scientists Discover That a Surprising Factor Improved The Effects of Ketamine in Mice

Posted by in categories: biotech/medical, sex

University of Maryland psychiatrist Polymnia Georgiou and colleagues accidentally came across an unexpected example of researchers unwittingly skewing a study’s results when their laboratory mice’s reactions to ketamine differed depending on the sex of the humans who administered the drug.

To check it wasn’t just a weird fluke, they did a blinded, randomized trial with an even mix of male and female experimenters. The mice indeed had a greater antidepressant response to ketamine when handled by male humans.

Obviously, the presence of male humans does not somehow change the properties of ketamine, so the researchers probed deeper to confirm the exact mechanism.

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Sep 1, 2022

Glycerol-3-phosphate shuttle is a backup system securing metabolic flexibility in neurons

Posted by in categories: biotech/medical, neuroscience, sex

Electrical activity in neurons is highly energy demanding and accompanied by rises in cytosolic Ca2+. Cytosolic Ca2+, in turn, secures energy supply by pushing mitochondrial metabolism either through augmented NADH transfer into mitochondria via the malate aspartate shuttle (MAS) or via direct activation of dehydrogenases of the TCA cycle after passing into the matrix through the mitochondrial Ca2+ uniporter (MCU). Another Ca2+-sensitive booster of mitochondrial ATP synthesis is the glycerol-3-phosphate shuttle (G3PS) whose role in neuronal energy supply has remained elusive. Essential components of G3PS are expressed in hippocampal neurons. Single neuron metabolic measurements in primary hippocampal cultures derived from rat pups of either sex reveal only moderate, if any, constitutive activity of G3PS. However, during electrical activity neurons fully rely on G3PS when MAS and MCU are unavailable. Under these conditions, G3PS is required for appropriate action potential firing. Accordingly, G3PS safeguards metabolic flexibility of neurons to cope with energy demands of electrical signaling.

SIGNIFICANCE STATEMENT:

Ca2+ ions are known to provide a link between the energy-demanding electrical activity and an adequate ATP supply in neurons. To do so, Ca2+ acts both, from outside and inside of the mitochondrial inner membrane. Neuronal function critically depend on this regulation and its defects are often found in various neurological disorders. Although interest in neuronal metabolism increases, many aspects thereof have remained unresolved. In particular, a Ca2+-sensitive NADH shuttling system, the glycerol-3-phosphate shuttle, has been largely ignored with respect to its function in neurons. Our results demonstrate that this shuttle is functional in hippocampal neurons and safeguards ATP supply and appropriate action potential firing when malate aspartate shuttle and mitochondrial Ca2+ uniporter are unavailable, thereby ensuring neuronal metabolic flexibility.

Aug 31, 2022

A database containing 800 million Chinese faces and vehicle license plates leaked

Posted by in categories: business, education, robotics/AI, sex, transportation

Millions of faces and car license plates were stored in a sizable Chinese database that was publicly accessible for months before it was silently removed in August.

A tech business called Xinai Electronics with headquarters in Hangzhou on China’s east coast is the owner of the disclosed data. In China, the firm creates systems for regulating entry for people and cars to workplaces, schools, construction sites, and parking lots. Its website boasts the use of facial recognition for a variety of uses beyond building access, including personnel management, such as payroll, monitoring employee attendance and performance, while its cloud-based vehicle license plate recognition system enables drivers to pay for parking in unattended garages that are managed by staff remotely.

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