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Apr 23, 2021

Toxic masculinity: Y chromosome contributes to a shorter lifespan in male flies

Posted by in categories: biotech/medical, genetics, life extension, sex

Males may have shorter lifespans than females due to repetitive sections of the Y chromosome that create toxic effects as males get older. These new findings appear in a study by Doris Bachtrog of the University of California, Berkeley published April 22 in PLOS Genetics.

In humans and other species with XY sex chromosomes, females often live longer than . One possible explanation for this disparity may be repetitive sequences within the genome. While both males and females carry these repeat sequences, scientists have suspected that the large number of repeats on the Y chromosome may create a “toxic y effect” that shortens males’ lives. To test this idea, Bachtrog studied male fruit flies from the species Drosophila miranda, which have about twice as much repetitive DNA as and a shorter lifespan. They showed that when the DNA is in its tightly packed form inside the cells of young male flies, the repeat sections are turned off. But as the flies age, the DNA assumes a looser form that can activate the repeat sections, resulting in .

The new study demonstrates that Y chromosomes that are rich in repeats are a genomic liability for males. The findings also support a more general link between repeat DNA and aging, which currently, is poorly understood. Previous studies in have shown that when repeat sections become active, they impair memory, shorten the lifespan and cause DNA damage. This damage likely contributes to aging’s physiological effects, but more research will be needed to uncover the mechanisms underlying repeat DNA’s .

Apr 21, 2021

Strange New Genetic Disease Discovered That Causes Children’s Brains to Develop Abnormally

Posted by in categories: biotech/medical, genetics, neuroscience, sex

One in 17 people will suffer from a rare disease at some time in their lives. Most of these rare diseases have a genetic cause and often affect children, but proving which gene change causes a disease is a huge challenge.


Scientists have discovered a new genetic disease, which causes some children’s brains to develop abnormally, resulting in delayed intellectual development and often early onset cataracts.

The majority of patients with the condition, which is so new it doesn’t have a name yet, were also microcephalic, a birth defect where a baby’s head is smaller than expected when compared to babies of the same sex and age.

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Mar 21, 2021

HDL Update: Age-Related Changes, All-Cause Mortality Risk, And Progress Towards The Optimal Range

Posted by in categories: biotech/medical, life extension, sex

Here’s my latest video!


In November 2020, I made a HDL video based on a meta-analysis in ~3.4 million subjects that was published in July 2020. In Dec 2020, a larger study (n=15.8 million subjects) was published-those data are presented in the video, and compared against the meta-analysis.

Continue reading “HDL Update: Age-Related Changes, All-Cause Mortality Risk, And Progress Towards The Optimal Range” »

Jan 26, 2021

Hormone helps regrow frog legs and may one day lead to a human therapy

Posted by in categories: biotech/medical, sex

Circa 2018


Frogs partly regrew their hind legs after a dose of the female sex hormone progesterone was applied to the wound site for just one day.

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Jan 17, 2021

The Physical Effects of Living in Space Could Create a New Human Species

Posted by in categories: biotech/medical, sex

The Moon and Mars are remote and forbidding but it’s fairly easy to turn their soil into construction material and mine it for water to drink and oxygen to breathe.


Several astronauts have spent more than a year in zero gravity, and they experienced muscle loss, brittle bones and difficulties with vision. A space station could be spun up to ameliorate these problems, and for colonists on the Moon and Mars, gravity would be reduced, not absent. Their capillaries and cardiovascular systems would adjust, and muscle mass would be shed.

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Jan 10, 2021

Distinct hypothalamic control of same- and opposite-sex mounting behaviour in mice

Posted by in categories: neuroscience, sex

Ultrasonic vocalizations of male mice distinguish aggressive, male-directed mounting from reproductive, female-directed mounting behaviours, which are represented by distinct ESR1-expressing populations of neurons in the ventromedial hypothalamus and medial preoptic area, respectively.

Dec 30, 2020

Dr Nicole Prause — Advancing Research In Sexual Psychophysiology, Sexual Biotechnology, And Sex-Tech

Posted by in categories: biotech/medical, neuroscience, sex

Dr. Nicole Prause, PhD is an American neuroscientist researching human sexual behavior, addiction, and the physiology of sexual response. She is also the founder of Liberos LLC, an independent research institute and biotechnology company.

Dr. Prause obtained her doctorate in 2007 at Indiana University Bloomington, with joint supervision by the Kinsey Institute for Research in Sex, Gender, and Reproduction, with her areas of concentration being neuroscience and statistics. Her clinical internship, in neuro-psychological assessment and behavioral medicine, was with the VA Boston Healthcare System’s Psychology Internship Training Program. Her research fellowship was in couples’ treatment of alcoholism was at Harvard University.

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Dec 8, 2020

Dr Daniel Monti — CEO & Founding Director, Marcus Institute of Integrative Health — Jefferson Health

Posted by in categories: biotech/medical, chemistry, education, health, neuroscience, sex

Exciting momentum!! — Home Depot Founder, Bernie Marcus (age 91), and the Adolph Coors Foundation (beer family), putting millions of $$$ into comprehensive integrative health and wellness — Good to see the trend!!


The Marcus Institute of Integrative Health was established in Philadelphia in 2017 by Thomas Jefferson University and Jefferson Health, and a multi-million $$$ grant from the Marcus Foundation (headed by it’s Chairman, Bernie Marcus, Co-Founder of The Home Depot) to expand the research, education and clinical care profile of Jefferson’s integrative medicine program, and to set the international standard of excellence in evidence-based, patient-centered integrative care.

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Dec 3, 2020

Glucosamine may reduce overall death rates as effectively as regular exercise, study suggests

Posted by in categories: biotech/medical, health, sex

After controlling for various factors — such as participants’ age, sex, smoking status and activity level — the researchers found that taking glucosamine/chondroitin every day for a year or longer was associated with a 39 percent reduction in all-cause mortality.

It was also linked to a 65 percent reduction in cardiovascular-related deaths. That’s a category that includes deaths from stroke, coronary artery disease and heart disease, the United States’ biggest killer.” “He explains that because this is an epidemiological study — rather than a clinical trial — it doesn’t offer definitive proof that glucosamine/chondroitin makes death less likely. But he does call the results “encouraging.””.


Glucosamine supplements may reduce overall mortality about as well as regular exercise does, according to a new epidemiological study from West Virginia University.

“Does this mean that if you get off work at five o’clock one day, you should just skip the gym, take a glucosamine pill and go home instead?” said Dana King, professor and chair of the Department of Family Medicine, who led the study. “That’s not what we suggest. Keep exercising, but the thought that taking a pill would also be beneficial is intriguing.”

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Nov 18, 2020

Bioethicist: We Should Give Sex Robots to Lonely Seniors

Posted by in categories: bioengineering, ethics, robotics/AI, sex

Newfound Autonomy

There are ways that a robot companion could outperform humans, Jecker says, by providing sympathetic and patient support free of judgment and condescension around the clock.

“It relates to issues of dignity,” Jecker told the Times. “The ability to be sexual at any age relates to your ability to have a life. Not just to survive, but to have a life, and do things that have value. Relationships. Bodily integrity. These things are a matter of dignity.”

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