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Category: neuroscience

Medicine’s next leap: Delivering gene therapies exactly where they’re needed

A quiet revolution is underway in modern medicine: Drug development is aiming to move from managing disease to correcting it through RNA and gene-editing therapies. But delivering these treatments safely and precisely to the right cells remains a major hurdle—especially in hard-to-target organs like the brain and kidneys.

Now, researchers led by a University of Ottawa Faculty of Medicine team offer highly compelling evidence that an elegant, nature-inspired solution lies in ultra-tiny, bubble-like structures called small extracellular vesicles (sEVs). These metabolic messengers, refined over millions of years of evolution, carry RNA—a nucleic acid that is a chemical cousin of DNA—and other molecules between cells.

In a nutshell, the research team’s new findings show that not all sEVs are alike: their cell of origin determines where they travel, with certain vesicles naturally targeting specific tissues in the body.

Group averages obscure how an individual’s brain controls behavior, study finds

Studying cognition by averaging data from many people’s brain scans hides how individuals use their brains, new Stanford Medicine research has shown. In particular, children who struggle with goal-oriented tasks show distinct patterns of brain activity when their data is analyzed individually, rather than as part of a group of kids with mixed abilities. The findings, which have implications for understanding how the brain works in such conditions as attention-deficit/hyperactivity disorder, will be published April 27 in Nature Communications.

“Investigating how dynamics unfold within individual brains can provide significant insights into the neuroscience of individual differences and help us tackle questions that cannot be answered using conventional approaches,” said Percy Mistry, Ph.D., a research scholar in psychiatry and behavioral sciences, and a lead author of the study.

Mistry shares lead authorship with Nicholas Branigan, MS, a research data analyst in psychiatry and behavioral sciences. The senior author is Vinod Menon, Ph.D., a professor of psychiatry and behavioral sciences and the Rachael L. and Walter F. Nichols, MD, Professor.

Breaking connections helps ideas spread farther, says physics-based study

Sticking with the same people might feel safe and comfortable. But a new Northwestern University study suggests it can actually trap new ideas and behaviors inside tight echo chambers. By contrast, the research, published in Communications Physics, shows that when interactions shift away from familiar contacts—and toward new ones—activity can spread more widely.

To explore how activities spread across networks, physicists developed a new theoretical framework that includes simple “learning” rules. While traditional network models assume relationships do not change, the new model shows what happens when connections change with experience. As interactions strengthen or weaken relationships, they gradually reshape the entire network.

The findings apply not only to ideas moving through social networks but to a wide range of systems where activity spreads, including infections passing among people, signals traveling through the brain and behaviors proliferating through groups of animals. Ultimately, the study suggests that whether something spreads or stalls may hinge on a simple choice: revisit the same connections or explore new ones.

Children may be born with two complex cognitive functions already established, research reveals

A new study is the first to show that two of our most sophisticated cognitive functions, using and understanding language and being able to sense how other people feel, have distinct origins in the brain in young children—matching what we know about the adult brain.

The findings suggest that these separate but related ways of processing complex concepts, both uniquely human skills, do not originate from overlapping brain areas and grow more distinct as the mind matures, which challenges prior theories. Instead, our brains appear to have evolved with discrete architecture and wiring enabling these different kinds of thinking.

Self-organizing ‘pencil beam’ laser could help scientists design brain-targeted therapies

MIT researchers discovered a paradoxical phenomenon in optical physics that could enable a new bioimaging method that’s faster and higher-resolution than existing technology. They discovered that, under the right conditions, a chaotic mess of laser light can spontaneously self-organize into a highly focused “pencil beam.”

Using this self-organized pencil beam, the researchers captured 3D images of the human blood-brain barrier 25 times faster than the gold-standard method, while maintaining comparable resolution. By showing individual cells absorbing drugs in real-time, this technology could help scientists test whether new drugs for neurodegenerative diseases like Alzheimer’s or ALS reach their targets in the brain, with greater speed and resolution.

“The common belief in the field is that if you crank up the power in this type of laser, the light will inevitably become chaotic. But we proved that this is not the case. We followed the evidence, embraced the uncertainty, and found a way to let the light organize itself into a novel solution for bioimaging,” says Sixian You, assistant professor in the MIT Department of Electrical Engineering and Computer Science (EECS), a member of the Research Laboratory for Electronics, and senior author of a paper on this imaging technique.

New neuroscience research shows how slowing your breathing alters your perception of the people around you

New brain imaging reveals that taking slow, deliberate breaths alters how accurately you recognize human emotions. The phase of your breath actually rewires the brain networks responsible for visual perception and passing judgment.

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