Lifeboat Foundation

Maybe eyes really are windows into the soul — or at least into the brain, as a new study finds.

Summary: Researchers have compiled a new, highly detailed 3D brain map that captures the shapes and activity of neurons in the visual neocortex of mice. The map is freely available for neuroscience researchers and artificial intelligence specialists to utilize.

Source: Allen Institute

Researchers from the University of Reading, in the UK, are using drones to give clouds an electrical charge, which could help increase rainfall in water-stressed regions.

Continue reading “Neuroscientists Unveil Wiring Diagram Containing 200,000 Cells and Nearly Half Billion Connections in Tiny Piece of a Mouse’s Brain” »

Psoriasis is a lifelong, autoimmune inflammatory disease. It often appears as a skin condition, but it is a systemic condition that can affect many parts of the body.

Psoriasis often causes skin lesions, but also a higher risk of other conditions, such as celiac, inflammatory bowel disease, and mental health issues. Find out more.

This study builds on an earlier paper by the Rothstein lab that looked at the most common genetic cause of ALS, a mutation in the C9orf72 gene (also referred to as the “C9 mutation”). There, they showed that the C9 mutation produced defects in a structure called the nuclear pore that is responsible for moving proteins and other molecules in and out of the nucleus of cells.

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal degenerative disease affecting the nerve cells in the brain and spinal cord responsible for controlling voluntary muscle movement. “Sporadic” or non-inherited ALS, accounts for roughly 90% percent of cases, and 10% of cases are due to known genetic mutations. By studying lab-grown neurons derived from skin or blood cells from 10 normal controls, eight with an ALS causing mutation, and 17 with non-inherited ALS, researchers have found a possible starting point for the dysfunction that causes the disease. The study, which was published in Science Translational Medicine, was funded in part by the National Institute for Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.

Using a library of ALS patient-derived cells, the research team led by Jeffrey Rothstein, M.D., Ph.D., at Johns Hopkins University School of Medicine, Baltimore, developed induced pluripotent stem cell (iPSC)-derived neurons from the patients’ cultured cells to discover a common defect regardless of whether the cell came from persons with inherited or non-inherited ALS. They report that in ALS nerve cells, there is an accumulation of a protein called CHMP7 in the nucleus of cultured nerve cells as well as in ALS samples from the brain region that controls movement. Treatments that decrease the amount of CHMP7 in the cultured cells prevented a series of abnormalities that are characteristic of ALS.

Continue reading “Researchers identify a cellular defect common to familial and sporadic forms of ALS” »

A company that makes an implantable brain-computer interface (BCI) has been given the go-ahead by the Food and Drug Administration to run a clinical trial with human patients. Synchron plans to start an early feasibility study of its Stentrode implant later this year at Mount Sinai Hospital, New York with six subjects. The company said it will assess the device’s “safety and efficacy in patients with severe paralysis.” https://www.engadget.com/fda-brain-computer-interface-clinic…ml?src=rss

A company that makes an implantable has been given the go-ahead by the Food and Drug Administration to run a clinical trial with human patients. Synchron plans to start an early feasibility study of its Stentrode implant later this year at Mount Sinai Hospital, New York with six subjects. The company said it will assess the device’s “safety and efficacy in patients with severe paralysis.”

Synchron received the FDA’s green light ahead of competitors like Elon Musk’s. Before such companies can sell BCIs commercially in the US, they need to prove that the devices work and are safe. The FDA will provide guidance for trials of BCI devices for patients with paralysis or amputation during a webinar on Thursday.

Continue reading “FDA clears Synchron’s brain-computer interface device for human trials” »

Synchron has beat rival Neuralink to human trials of its “implantable brain computer interface.”

The chip will be studied in six patients later this year as a possible aid for paralyzed people.

Elon Musk previously used Neuralink’s chip in a monkey, which then played video games with its mind.

Continue reading “This 20-person biotech firm just beat Elon Musk’s Neuralink in getting the OK to test brain chip implants in humans with paralysis” »

Several Clostridium species enriched in children with autism closely interacted with each other and formed a connected group. Clostridia species have been linked with autism via the production of clostridial toxins which can damage the central nervous system, point out the researchers.

Significantly fewer gut bugs linked to neurotransmitter activity.

Children with autism seem to have a distinctive and underdeveloped range and volume of gut bacteria (microbiome) that isn’t related to their diet, suggests a small study published online in the journal Gut.

Continue reading “New Research Finds Children With Autism Have a Distinctive Gut Microbiome” »

A technique developed at Western University to visually iron out the wrinkles and folds in one region of the brain may provide researchers a more accurate picture to understand brain disorders.

Continue reading “Unfolding the hippocampus” »

Thrilled to see Paradromics’ $20M fund raise lead by the talented Dr. Amy Kruse! Paradromics is building a brain computer interface supported by DARPA’s Biologi… See More.

The investment demonstrates confidence in Paradromics as a well-positioned player in the $200 billion BCI therapy market. Last year, Paradromics successfully completed testing of its platform, demonstrating the largest ever electrical recording of cortical activity that exceeded more than 30000 electrode channels in sheep cortex. This recording allowed researchers to observe the brain activity of sheep in response to sound stimuli with high fidelity.

“We are combining the best of neural science and medical device engineering to create a robust and reliable platform for new clinical therapies,” said Paradromics CEO Matt Angle. “This funding round is a validation of both our technology and strategic vision in leading this important developing market.”

Continue reading “Paradromics Raises $20MM in Seed Funding Led by Prime Movers Lab to Advance Brain Computer Interfaces” »