In the brain, memory involves release of neurotransmitters and transport of ions through nanoconfined channels. This Perspective discusses how nanofluidic memristors emulate this confined ion transport, highlighting the materials, design strategies and challenges involved in developing brain-inspired computing technologies.
New research from the Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC has discovered subtle but widespread differences in the brain’s communication networks in people with bipolar disorder, offering new insight into how illness severity and treatment may relate to brain wiring.
Published in Biological Psychiatry, the study was led by Leila Nabulsi, Ph.D., a senior research associate at the Stevens INI, together with Dara M. Cannon, Ph.D., professor at the University of Galway, Ireland. The team analyzed brain scans from 449 people with bipolar disorder and 510 healthy controls across 16 international research sites through the ENIGMA Bipolar Disorder Working Group.
This work was made possible by ENIGMA, an international consortium founded and led in part by Paul M. Thompson, Ph.D., associate director of the Stevens INI. ENIGMA brings together researchers worldwide to pool their brain imaging and clinical data, allowing them to detect subtle patterns that would be difficult to identify in smaller studies.
It might soon be “game over” for the video game controller. Yale researchers have developed a new kind of brain-computer interface (BCI) that lets humans play video games directly with their brains. Using real-time fMRI (functional MRI), they confirmed that the technology could help humans control a computer with their brain activity in a highly efficient way. The study appears in the journal Nature Neuroscience.
A BCI is technology that allows a human to control a computer with brain activity. Historically, they have not been effective. BCIs built using real-time neurofeedback from fMRI—a type of MRI scan showing which areas of the brain are most active over time—require up to 10 long training sessions per person, and even then the learning effects are modest. About a third of users never gain control, regardless of how many hours they practice.
“The Self as Software: Transcending and Enhancing the Brain” presented by Susan Schneider. Co-sponsored by Cognitive Science, Computing Sciences, and Philosophy
Emerging evidence highlights the brain renin–angiotensin system (RAS) as a key regulator of reward, memory, and stress. While these discoveries established the brain RAS as a promising therapeutic target for interventions in neurological and neuropsychiatric disorders, translational progress is hampered by the lack of an integrative mechanistic framework. Here, we consolidate accumulating evidence on the molecular and system-level roles of the brain RAS in reward, memory, and stress pathways, and its dual regulatory architecture. Pharmacological RAS modulation regulates domain-specific signaling in frontostriatal reward circuits, hippocampal–prefrontal memory networks, and frontolimbic fear networks. We evaluate the transdiagnostic therapeutic potential in neurological and neuropsychiatric disorders (e.g.
Tracking the brain’s blood flow during neurosurgery represents one of the most critical and challenging parts of the operation. A brief interruption can mean the difference between permanent damage and full recovery, but it’s difficult to track blood flow across the surgical field.
Now, researchers at The University of Texas at Austin have developed a new way to monitor blood flow with standard camera hardware. The method, called sinusoidal intensity modulation speckle imaging (SIMSI), uses the physics of dynamic light scattering to image blood flow noninvasively, across a wide field of view and without high-speed cameras. The paper is published in the journal Proceedings of the National Academy of Sciences.
Going through surgery can take a significant toll on a patient’s physical health and capabilities, especially if they are elderly. A recent study found that the effects extend far beyond mobility and pain management, as the operation may also lead to a significant loss of overall cognitive sharpness.
Researchers tracked 560 adults over 70 with no signs of dementia for six years after major surgeries such as hip replacements and abdominal procedures, watching how their memory and thinking skills changed over time. They found that nearly 15% of participants experienced a sharp decline in memory and thinking abilities shortly after surgery, with their condition continuing to deteriorate over time.
The three biggest warning signs that made a person more likely to fall into a severe decline were: being older, having lower mental test scores before the surgery, and developing postoperative delirium, which is a mental state where a person has episodes of confusion and disordered thinking that can develop over hours or days after the surgery.
Autism spectrum disorder (ASD), commonly referred to as autism, is a neurodevelopmental condition characterized by differences in social interactions, communication, behavior and the processing of sensory stimuli. Notably, the experiences, aptitudes and needs of autistic people can vary significantly.