Lifeboat Foundation

DLB is a common cause of dementia. It starts by the abnormal accumulation of the protein alpha-synuclein in the brain. This produces degeneration of the brain and causes problems with thinking, movement, and behavior. Eventually, the disease leads to dementia and death. Doctors use a imaging technique called FDG-PET to assess how the brain is affected in DLB. However, until now, there was no information on how these brain changes develop over time.

The study, led by Dr. Daniel Ferreira at the Department of Neurobiology, Care Sciences and Society, followed 35 patients with DLB, 37 patients with early-stage DLB (called prodromal DLB), and 100 healthy people from Mayo Clinic (USA), for an average of 3.8 years. The researchers found that brain degeneration starts early in prodromal DLB and worsens as the disease progresses.

“We discovered that people with prodromal DLB had faster degeneration in certain brain areas compared to healthy individuals,” said Dr. Ferreira.” This information is crucial for monitoring disease progression from early stages and planning clinical trials for new treatments.”

Continue reading “Longitudinal FDG-PET Metabolic Change Along the Lewy Body Continuum” »

Second, Synchron will explore the development of a groundbreaking foundation model for brain inference. By processing Synchron’s neural data on an unprecedented scale, this initiative will create scalable, interpretable brain-language models with the potential to transform neuroprosthetics, cognitive expression, and seamless interaction with digital devices.

“Synchron’s vision is to scale neurotechnology to empower humans to connect to the world, and the NVIDIA Holoscan platform provides the ideal foundation,” said Tom Oxley, M.D., Ph.D., CEO & Founder, Synchron. “Through this work, we’re setting a new benchmark for what BCIs can achieve.”

NEW YORK—(BUSINESS WIRE)— Synchron, a category-defining brain-computer interface (BCI) company, announced today a step forward in implantable BCI technology to drive the future of neurotechnology. Synchron’s BCI technology, in combination with the NVIDIA Holoscan platform, is poised to redefine the possibilities of real-time neural interaction and intelligent edge processing.

Synchron will leverage NVIDIA Holoscan to advance a next-generation implantable BCI in two key domains. First, Synchron will enhance real-time edge AI capabilities for on-device neural processing, improving signal processing and multi-AI inference technology. This will reduce system latency, bolster privacy, and provide users with a more responsive and intuitive BCI experience. NVIDIA Holoscan provides Synchron with: (i) a unified framework supporting diverse AI models and data modalities; (ii) an optimized application framework, from seamless sensor I/O integration, GPU-direct data ingestion, to accelerated computing and real-time AI.

Continue reading “Synchron to Advance Implantable Brain-Computer Interface Technology with NVIDIA Holoscan” »

Source: NUS

Researchers have uncovered novel insights into how brain function disruptions related to cerebrovascular disease (CeVD) interact with Alzheimer’s disease (AD) pathology to impact neurodegeneration and cognition in older adults.

Led by Associate Professor Juan Helen Zhou, Director of the Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), the research team revealed a brain functional connectome phenotype that is related to multiple CeVD markers and contributes additively to cognitive decline and neurodegeneration alongside AD.

Being able to erase bad memories and traumatic flashbacks could help in the treatment of a host of different mental health issues, and scientists have found a promising new approach to do just this: weakening negative memories by reactivating positive ones.

In an experiment covering several days, an international team of researchers asked 37 participants to associate random words with negative images, before attempting to reprogram half of those associations and ‘interfere’ with the bad memories.

“We found that this procedure weakened the recall of aversive memories and also increased involuntary intrusions of positive memories,” write the researchers in their published paper.

The brain’s response to emotional words is guided by neurotransmitters like dopamine and serotonin, shaping how we interpret language. Surprising new research shows even the thalamus is involved, bridging emotion and cognition.

Summary: Researchers have uncovered how neurotransmitters in the brain respond to the emotional content of language, shedding light on the intersection of emotion, cognition, and communication. Using advanced techniques, the team simultaneously measured dopamine, serotonin, and norepinephrine release in patients during exposure to emotionally charged words.

Continue reading “Dopamine and Serotonin Drive Emotional Word Processing” »

Neuralink Corp.’s brain-computer device has been implanted in a third patient and the company has plans for about 20 to 30 more implants in 2025, founder Elon Musk said.

“We’ve got now three humans with Neuralinks implanted and they’re all working well,” Musk said during an event in Las Vegas this week that was streamed on X, his social media service.

Neuralink is one of a growing group of startups developing brain implants that can help treat conditions such as paralysis and ALS. They are experimental procedures that usually require opening up the skull to place electrodes in the brain tissue. A year ago, Neuralink said it had implanted its device in its initial patient, Noland Arbaugh.

In the early 20th century, the mathematician Godel showed that any mathematical system is incomplete, using a version of the self-referential paradox: ‘this sentence is not true’. Here, neuroscientist and philosopher, Erik Hoel, argues this incompleteness extends to the scientific project as a whole; in part due to science’s reliance on mathematics. More radically, Hoel argues, this incompleteness of science may account for why we can’t find scientific evidence for consciousness anywhere in the world.

Let’s say you lived in a universe where you really were some sort of incarnated soul in a corporeal body. Or some sort of agent from a vaster reality embedded in a simulation (depending on definitions, the two scenarios might not be that different). What would the science in such a dualistic universe look like?

Sign up to get exclusive access.

Summary: Researchers have identified and mapped diverse cell types in the cochlear nucleus, the brainstem region responsible for processing sound. Using advanced molecular techniques, they uncovered distinct and newly identified cell types that process specific sound features, such as sharp noises or pitch changes.

These findings challenge existing ideas about hearing and pave the way for targeted treatments for auditory disorders. By creating a cellular and molecular atlas, scientists can now develop more precise therapies for conditions like hearing loss, advancing the field of personalized auditory medicine.

Neuralink has implanted its device in third human patient and plans more procedures in 2025. The device allows paralyzed individuals to control external devices with their thoughts. The company is conducting studies to evaluate the safety and efficacy of its brain implants. Neuralink aims to revolutionize neurotechnology.