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Category: neuroscience – Page 4

Fruit flies offer new insights into how Alzheimer’s disease risk genes affect the brain

Scientists have identified hundreds of genes that may increase the risk of developing Alzheimer’s disease but the roles these genes play in the brain are poorly understood. This lack of understanding poses a barrier to developing new therapies, but in a study published in the American Journal of Human Genetics, researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital offer new insights into how Alzheimer’s disease risk genes affect the brain.

“We studied fruit fly versions of 100 human Alzheimer’s disease risk genes,” said first author Dr. Jennifer Deger, a neuroscience graduate in Baylor’s Medical Scientist Training Program (M.D./Ph. D.), mentored by Drs. Joshua Shulman and Hugo Bellen.

“We developed fruit flies with mutations that ‘turned off’ each gene and determined how this affected the fly’s structure, function and stress resilience as the flies aged.”

Diffusion markers of dendritic density and arborization in gray matter predict differences in intelligence

Previous studies suggest that individual differences in intelligence correlate with circuit complexity and dendritic arborization in the brain. Here the authors use NODDI, a diffusion MRI technique, to confirm that neurite density and arborization are inversely related to measures of intelligence.

Attention lapses due to sleep deprivation coincide with a flushing of fluid from the brain, research reveals

Nearly everyone has experienced it: After a night of poor sleep, you don’t feel as alert as you should. Your brain might seem foggy, and your mind drifts off when you should be paying attention.

A new study from MIT reveals what happens inside the brain as these momentary failures of attention occur. The scientists found that during these lapses, a wave of (CSF) flows out of the brain—a process that typically occurs during sleep and helps to wash away waste products that have built up during the day. This flushing is believed to be necessary for maintaining a healthy, normally functioning brain.

When a person is sleep-deprived, it appears that their body attempts to catch up on this cleansing process by initiating pulses of CSF flow. However, this comes at a cost of dramatically impaired attention.

Drugs approved for treating pain may also reduce bone cancer growth

Peripheral afferent neurons—nerves that send signals from all areas of the body to the central nervous system (brain and spinal cord)—are known to infiltrate and grow within malignant bone tumors called osteosarcomas, often accompanied by severe pain.

In a study published in Proceedings of the National Academy of Sciences, a multicenter research team led by Johns Hopkins Medicine reports that two analgesic drugs, bupivacaine and rimegepant, which are used to inhibit the formation and functioning of these neurons, not only relieve -associated pain in , but also slow the unchecked growth of the cancer.

“Our findings suggest that these two medications—already approved by the U.S. Food and Drug Administration [FDA] for relieving [bupivacaine] and migraines [rimegepant]—might one day be repurposed as anti-tumor therapies,” says study lead author Sowmya Ramesh, Ph.D., a postdoctoral researcher in pathology at the Johns Hopkins University School of Medicine.

Serotonin produced by gut bacteria provides hope for a novel IBS treatment

Research from the University of Gothenburg, Sweden, clarifies the complex interaction between gut bacteria and irritable bowel syndrome (IBS). Experiments demonstrate that gut bacteria can produce the important substance serotonin. The finding may lead to future treatments.

IBS is a common gastrointestinal disorder, more common in women, with symptoms such as abdominal pain, constipation or diarrhea. The cause of the disease is not clear, but the intestinal environment, including the gut microbiota and serotonin, appear to be important factors.

Serotonin is best known as a neurotransmitter in the brain, but over 90% of the body’s serotonin is produced in the gut, where it controls bowel movements via the enteric nervous system, sometimes called the “gut–brain.”

Iontronic Circuits: Building Intelligence in Brine

Experiments with membranes offer a path toward scalable neuromorphic computing.

Imagine a future in which computers process information not with streams of electrons but with hydrated ions flowing through salt water, a system that mimics how the brain itself computes. This emerging field—known as iontronics, a portmanteau of ions and electronics—is rapidly growing as researchers design neuromorphic computing devices, inspired by animal nervous systems and powered by electrolyte solutions at the nanoscale [1–3]. Since Leon Chua introduced the memory resistor or “memristor” in the 1970s [4], these components have been considered revolutionary building blocks for neuromorphic computing. A memristor’s electrical resistance depends on the current that flowed through it before it was powered off, offering a way to store information. Unlike solid-state memristors, fluidic ones still face challenges in terms of scalability and integration with a circuit.

Scientists Discover a Key Biological Difference Between Psychopaths and Normal People

Psychopaths have a 10% larger striatum than non-psychopaths, suggesting biological differences in brain structure. This enlargement is tied to impulsivity and a higher craving for stimulation.

The discovery, seen in both men and women, points to psychopathy’s roots in neurodevelopment. It could lead to better understanding and interventions for antisocial behavior.

Brain scans reveal key difference in psychopaths.

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