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Category: policy

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks

(Cell Reports 16, 2641–2650; September 6, 2016)

The original version of this article, published on August 25, 2016, included an incorrect immunoblot image. The anti-H3 loading control shown in Figure 2C was inadvertently duplicated from a separate project during manuscript preparation. This was an unintentional oversight.

Normally, the authors would replace the incorrect image with the correct one. However, because the experiments were performed more than 10 years ago, the original image/film could not be located. This is consistent with the authors’ institutional data-retention policy, which requires data to be kept for only three years after a project’s completion. After discussion, the authors and editors agreed that removing the immunoblot images from Figure 2C would prevent confusion for future readers without changing the article’s central conclusions.

Cloudflare misconfiguration behind recent BGP route leak

Cloudflare has shared more details about a recent 25-minute Border Gateway Protocol (BGP) route leak affecting IPv6 traffic, which caused measurable congestion, packet loss, and approximately 12 Gbps of dropped traffic.

The BGP system helps route data across different networks called autonomous systems (AS) that send it to destination through smaller networks on the internet.

The incident was caused by an accidental policy misconfiguration on a router and affected external networks beyond Cloudflare customers.

Burden of Central Nervous System Cancer in the United States

While incidence rates for central nervous system cancer remained stable from 1990 to 2021, both mortality and disability-adjusted life-years (DALYs) declined. Disparities by geography, age, sex, and sociodemographic status highlight needs for targeted health policy reforms and resource redistribution.

Findings In this cross-sectional study, analysis of the Global Burden of Disease Study 2021 data on US CNS cancers revealed that although the incidence rate remained relatively stable, both disability-adjusted life-years and mortality rates declined. However, substantial disparities persisted across geographical location, age, sex, and sociodemographic profile.

Meaning The persistent disparity in CNS cancer burden highlights the urgent need to reevaluate public health policies and redistribute health care resources to better support marginalized and underserved populations.

Cognition all the way down 2.0: neuroscience beyond neurons in the diverse intelligence era

This paper formalizes biological intelligence as search efficiency in multi-scale problem spaces, aiming to resolve epistemic deadlocks in the basal “cognition wars” unfolding in the Diverse Intelligence research program. It extends classical work on symbolic problem-solving to define a novel problem space lexicon and search efficiency metric. Construed as an operationalization of intelligence, this metric is the decimal logarithm of the ratio between the cost of a random walk and that of a biological agent. Thus, the search efficiency measures how many orders of magnitude of dissipative work an agentic policy saves relative to a maximal-entropy search strategy. Empirical models for amoeboid chemotaxis and barium-induced planarian head regeneration show that, under conservative (i.e.

Ben & Marc: Why Everything Is About to Get 10x Bigger

The media and tech landscape is undergoing a significant transformation driven by advancements in AI, technology, and new structures, enabling entrepreneurs and companies to achieve exponential growth and innovation ## ## Questions to inspire discussion.

Building Your Own Platform.

🚀 Q: How can writers escape traditional media constraints? A: Launch on decentralized platforms like Substack where you build your own brand and business as a “non-fungible writer”, potentially creating organizations 10x larger than traditional media companies you’d work for.

💰 Q: What makes writer-led platforms attractive investments? A: Platforms become cornerstone franchises when writers only succeed by making the platform successful, creating aligned incentives that generate significant returns while enabling top talent to build independent businesses.

📊 Q: What content opportunity exists in decentralized media? A: A barbell market is emerging with mainstream filler content on one end and massive untapped demand for high-quality niche content on the other, creating opportunities across various specialized domains.

Leveraging AI for Business.

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LOTUSLITE Backdoor Targets U.S. Policy Entities Using Venezuela-Themed Spear Phishing

Security experts have disclosed details of a new campaign that has targeted U.S. government and policy entities using politically themed lures to deliver a backdoor known as LOTUSLITE.

The targeted malware campaign leverages decoys related to the recent geopolitical developments between the U.S. and Venezuela to distribute a ZIP archive (“US now deciding what’s next for Venezuela.zip”) containing a malicious DLL that’s launched using DLL side-loading techniques. It’s not known if the campaign managed to successfully compromise any of the targets.

The activity has been attributed with moderate confidence to a Chinese state-sponsored group known as Mustang Panda (aka Earth Pret, HoneyMyte, and Twill Typhoon), citing tactical and infrastructure patterns. It’s worth noting that the threat actor is known for extensively relying on DLL side-loading to launch its backdoors, including TONESHELL.

El Niño and La Niña synchronize global droughts and floods, study finds

Water extremes such as droughts and floods have a huge impact on communities, ecosystems, and economies. Researchers with The University of Texas at Austin have turned their attention to tracking these extremes across Earth and have discovered what is driving them.

In a recent study published in AGU Advances, the researchers found that over the past two decades ENSO, a climate pattern in the equatorial Pacific Ocean that includes El Niño and La Niña, has been the dominant driver of total water storage extremes at the global level. What’s more, the researchers found that ENSO has a synchronizing effect on water storage extremes across continents.

Study co-author Bridget Scanlon, a research professor at the Bureau of Economic Geology at the UT Jackson School of Geosciences, said that understanding how extremes unfold across the world has humanitarian and policy impacts.

Trump’s Reprieve for Nvidia’s H200 Spurred by Huawei’s AI Gains

President Donald Trump decided to let Nvidia Corp. sell its H200 artificial intelligence chips to China after concluding the move carried a lower security risk because the company’s Chinese archrival, Huawei Technologies Co., already offers AI systems with comparable performance, according to a person familiar with the deliberations.

Administration officials who weighed whether to clear Nvidia’s H200 had considered multiple possible scenarios, factoring in the views of national security hawks in Washington, said the person. Options ranged from exporting zero AI chips to China to allowing exports of everything to flood the Chinese market and overwhelm Huawei. Ultimately the policy backed by Trump called for clearing H200s to China while holding back the latest Nvidia chips for American customers, the person said.

Gubernatorial Candidate Promises ROBOTS To Every Californian… Is Cenk Buying it?

Here’s my full 30-min interview from yesterday with Cenk Uygur on TYT! We cover a lot of things: superintelligence, Basic Income, my Automated Abundance Economy, and my California Governor run.

Cenk Uygur and Zoltan Istvan discuss the future of AI and California on The Young Turks. Do you agree with TYT’s take? Tell us what you think in the comments below. SUBSCRIBE today: ☞ https://go.tyt.com/ytsubscribe.

Get paid to use your phone less! Switch to Noble Mobile today: https://go.tyt.com/mobile.

CHAPTERS:
0:00 Zoltan Istvan on running as a Democrat.
0:45 Transhumanist party.
2:30 Zoltan on AI & technology.
9:50 No corporate or Israel lobby money.
10:20 Zoltan’s policy priorities.
11:40 Robots for every Californian?!
14:00 Universal basic income.
23:00 Taxing robots?!
25:50 Reaching across the aisle.
28:00 AI revolution.

🔥 Tired of corporate media? Get honest news and bold commentary with TYT.

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