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Evaluating AI and machine learning models in cheminformatics: benchmarking techniques and case studies

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PAPO: Perception-Aware Policy Optimization for Multimodal Reasoning

Suppose you’re trying to solve a puzzle that includes both words and pictures — like reading a comic strip and figuring out what happens next. That’s the kind of challenge today’s AI faces in “multimodal reasoning,” where it must understand both text and images to think and respond accurately.

Grok 4 for a spin this weekend to build this game prototype

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Rivian CEO Exposes Legacy Automaker EV Lies

Rivian CEO RJ Scaringe claims that legacy automakers are intentionally slowing down electric vehicle adoption and hindering competition to protect their profits from gas-powered vehicles, which could threaten their survival and allow newer EV makers like Rivian and Tesla to dominate the market ## ## Questions to inspire discussion.

Legacy Automakers and EVs.

🚗 Q: Why are legacy automakers resistant to selling EVs? A: Legacy automakers don’t want to sell EVs because they make good margins on low-efficiency gas cars and can sell them at a premium price, preferring to see the EV market disappear.

🏛️ Q: How are legacy automakers fighting against EV policies? A: Legacy automakers are the biggest adversaries of EV policies, spending the most energy fighting against them in DC, reflecting their desire for the EV market to vanish. Rivian’s Challenges and Strategy.

💰 Q: What financial challenge does Rivian face? A: Rivian has a massive $23 billion debt, making it more indebted than any startup has ever been, requiring 10–20 years to become cash flow positive.

🛻 Q: How is Rivian addressing its product pricing? A: Rivian’s R2 electric truck, launching in 2025, will target a **$45,000 starting price, a strategic move to make their products more accessible.

AI and biophysics unite to forecast high-risk viral variants before outbreaks

When the first reports of a new COVID-19 variant emerge, scientists worldwide scramble to answer a critical question: Will this new strain be more contagious or more severe than its predecessors? By the time answers arrive, it’s frequently too late to inform immediate public policy decisions or adjust vaccine strategies, costing public health officials valuable time, effort, and resources.

In a pair of recent publications in Proceedings of the National Academy of Sciences, a research team in the Department of Chemistry and Chemical Biology combined biophysics with artificial intelligence to identify high-risk viral variants in record time—offering a transformative approach for handling pandemics. Their goal: to get ahead of a virus by forecasting its evolutionary leaps before it threatens public health.

“As a society, we are often very unprepared for the emergence of new viruses and pandemics, so our lab has been working on ways to be more proactive,” said senior author Eugene Shakhnovich, Roy G. Gordon Professor of Chemistry. “We used fundamental principles of physics and chemistry to develop a multiscale model to predict the course of evolution of a particular variant and to predict which variants will become dominant in populations.”

Ocean model simulations shed light on long-term tritium distribution in released Fukushima water

Operators have pumped water to cool the nuclear reactors at the Fukushima Daiichi Nuclear Power Plant (FDNPP) since the accident in 2011 and treated this cooling water with the Advanced Liquid Processing System (ALPS), which is a state-of-the-art purification system that removes radioactive materials, except tritium.

As part of the water molecule, tritium radionuclide, with a half-life of 12.32 years, is very costly and difficult to remove. The ALPS-treated water was accumulating and stored at the FDNPP site and there is limited space to store this water. Therefore, in 2021, the Government of Japan announced a policy that included discharging the ALPS-treated water via an approximately one-kilometer-long tunnel into the ocean. Planned releases of the ALPS-treated water diluted with began in August 2023 and will be completed by 2050.

In a new numerical modeling study, researchers have revealed that the simulated increase in tritium concentration in the Pacific Ocean due to the tritium originating from the ALPS-treated water is about 0.1% or less than the tritium background concentration of 0.03−0.2 Bq/L in the vicinity of the site (within 25 km) and beyond.

Building Markets to Scale Carbon Management Solutions

Amid growing policy momentum, Carbon Management Solutions (CMS), including Carbon Capture, Utilization and Storage (CCUS), clean hydrogen, and emerging carbon markets, are gaining critical support. This report examines the evolving landscape of CMS, highlighting emerging value chains integration and novel business models.

Star Trek’s Biggest Plot Hole: UFOs and the Prime Directive

In the grand cosmology of Star Trek, the Prime Directive stands as both a legal doctrine and a quasi-religious tenet, the sacred cow of Federation ethics. It is the non-interference policy that governs Starfleet’s engagement with pre-warp civilizations, the bright line between enlightenment and colonial impulse. And yet, if one tilts their head and squints just a little, a glaring inconsistency emerges: UFOs. Our own real-world history teems with sightings, leaked military footage, close encounters of the caffeinated late-night internet variety — yet in the Star Trek universe, these are, at best, unacknowledged background noise. This omission, this gaping lacuna in Trek’s otherwise meticulous world-building, raises a disturbing implication: If the Prime Directive were real, then the galaxy is full of alien civilizations thumbing their ridged noses at it.

To be fair, Star Trek often operates under what scholars of narrative theory might call “selective realism.” It chooses which elements of contemporary history to incorporate and which to quietly ignore, much like the way a Klingon would selectively recount a battle story, omitting any unfortunate pratfalls. When the series does engage with Earth’s past, it prefers a grand mythos — World War III, the Eugenics Wars, Zephram Cochrane’s Phoenix breaking the warp barrier — rather than grappling with the more untidy fringes of historical record. And yet, our own era’s escalating catalog of unidentified aerial phenomena (UAPs, as the rebranding now insists) would seem to demand at least a passing acknowledgment. After all, a civilization governed by the Prime Directive would have had to enforce a strict policy of never being seen, yet our skies have been, apparently, a traffic jam of unidentified blips, metallic tic-tacs, and unexplained glowing orbs.

This contradiction has been largely unspoken in official Trek canon. The closest the franchise has come to addressing the issue is in Star Trek: First Contact (1996), where we see a Vulcan survey ship observing post-war Earth, waiting for Cochrane’s historic flight to justify first contact. But let’s consider the narrative implication here: If Vulcans were watching in 2063, were they also watching in 1963? If Cochrane’s flight was the green light for formal engagement, were the preceding decades a period of silent surveillance, with Romulan warbirds peeking through the ozone layer like celestial Peeping Toms?