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Algorithm precisely quantifies flow of information in complex networks

Networks are systems comprised of two or more connected devices, biological organisms or other components, which typically share information with each other. Understanding how information moves between these connected components, also known as nodes, could help to advance research focusing on numerous topics, ranging from artificial intelligence (AI) to neuroscience.

To measure the directional flow of information in systems, scientists typically rely on a mathematical construct known as transfer entropy, which essentially quantifies the rate at which information is transmitted from one node to another. Yet most strategies for calculating transfer entropy developed so far rely on approximations, which significantly limits their accuracy and reliability.

Researchers at AMOLF, a institute in the Netherlands, recently developed a computational algorithm that can precisely quantify transfer entropy in a wide range of complex networks. Their algorithm, introduced in a paper published in Physical Review Letters, opens new exciting possibilities for the study of information transfer in both biological and engineered networks.

Living brain tissue reveals unique RNA and protein patterns missed in postmortem studies

Two new research papers from the Living Brain Project at Mount Sinai present what is, by several metrics, the largest investigation ever performed of the biology of the living human brain. The papers present unequivocal evidence that brain tissue from living people has a distinct molecular character, an observation that until now was missed because brain tissue from living people is rarely studied.

The findings, which were recently published in Molecular Psychiatry and PLOS ONE, call for a re-evaluation of how scientists study the human brain.

Postmortem brain samples—tissue samples obtained from individuals who donate their brain to science after death—are currently the standard tissue source used by scientists to study how our brains work at the deepest level.

Shall we Dance in Free-Space? a Choice of Freedom!

Humanity stands at a crossroads. Our beautiful Earth, cradle of all we know, is straining under the weight of nearly 8.5 billion people. Environmental degradation, social inequity, and resource scarcity deepen by the day. We are reaching the limits of a single-planet civilization. We can face this challenge in two ways. Some will cling to the old patterns—fighting over dwindling resources and defending narrow borders. Others will rise above, expanding into space not to escape Earth, but to renew and sustain it. These pioneers—the Space Settlers —will carry the next chapter of civilization beyond our home planet.

The Humanist Path: Living in Free Space. When people imagine living beyond Earth, they often picture Lunar or Martian colonies. Yet, from a humanist perspective, a better path exists: rotating free space habitats, as envisioned by Gerard K. O’Neill. These are vast, spinning structures orbiting Earth or the Moon, or standing at Lagrange Libration Points, designed to simulate Earth’s gravity and sustain full, flourishing communities. Unlike planetary colonies bound to weak gravity, dust, or darkness, O’Neill habitats offer: 1g simulated gravity to preserve human health; continuous sunlight and abundant solar energy; freedom of movement, as habitats can orbit safely or relocate if needed. More than technical achievements, these habitats embody the Enlightenment spirit—the belief that reason, ethics, and creativity can design environments of dignity, beauty, and freedom.

Freedom and Human Dignity in Space. Freedom is at the heart of humanity’s destiny. Consider a lunar settler who finds his bones too fragile to withstand Earth’s gravity—trapped by biology, after a few years living on the Moon. In contrast, inhabitants of a rotating habitat retain the freedom to return on Earth, at will. Simulated gravity safeguards their health, ensuring that space settlement remains reversible and voluntary. Freedom of movement leads naturally to freedom of culture. In a habitat like “New Gaia”, thousands of people from all nations live together: Russians celebrating Maslenitsa, Indians lighting Diwali lamps, and space-born storytellers sharing ancient myths. New traditions also emerge—festivals, music, and art inspired by life between worlds. These habitats can become beacons of a new Renaissance —a rebirth of cultural and creative freedom beyond the constraints of geography and politics.

For the first time, scientists pinpoint brain cells linked to depression

Scientists identified two types of brain cells, neurons and microglia, that are altered in people with depression. Through genomic mapping of post-mortem brain tissue, they found major differences in gene activity affecting mood and inflammation. The findings reinforce that depression has a clear biological foundation and open new doors for treatment development.

Holocene skeletal samples challenge link between sedentary lifestyles and age-related bone weakening

Research led by Vladimír Sládek sheds new light on how bones age, questioning long-standing assumptions that sedentary lifestyles are the primary cause of weakening bone strength in modern humans.

The study analyzed 1,881 adult humeri, femora, and tibiae from European Holocene populations to examine how and structure change with age. Surprisingly, researchers found that patterns of diaphyseal (shaft) aging were consistent across both Early and Late Holocene adults—despite significant differences in physical activity levels between the two groups. The research is published in the journal Science Advances.

“Our findings suggest that lifestyle differences may not fully explain age-related declines in bone strength,” said Dr. Sládek. “Instead, the biology of bone growth and aging itself plays a critical role.”

Scientists discover brain circuit that can switch off chronic pain

Scientists have pinpointed Y1 receptor neurons in the brain that can override chronic pain signals when survival instincts like hunger or fear take precedence. Acting like a neural switchboard, these cells balance pain with other biological needs. The research could pave the way for personalized treatments that target pain at its brain source—offering hope for millions living with long-term pain.

How a Molecular Motor Minimizes Energy Waste

Turning a biologically important molecular motor at a constant rate saves energy, according to experiments.

Within every biological cell is an enzyme, called adenosine triphosphate (ATP) synthase, that churns out energy-rich molecules for fueling the cell’s activity. New experiments investigate the functioning of this “energy factory” by artificially cranking one of the enzyme’s molecular motors [1]. The results suggest that maintaining a fixed rotation rate minimizes energy waste caused by microscopic fluctuations. Future work could confirm the role of efficiency in the evolutionary design of biological motors.

ATP synthase consists of two rotating molecular motors, Fo and F1, that are oriented along a common rotation axis and locked together so that the rotation of Fo exerts a torque on the shaft in the middle of F1. The resulting motion within F1 helps bring together the chemical ingredients of the molecule ATP, which stores energy that can later be used in cellular processes.

Cryo-imaging gives deeper view of thick biological materials

Electron microscopy is an exceptional tool for peering deep into the structure of isolated molecules. But when it comes to imaging thicker biological samples to understand how those molecules function in their cellular environments, the technology gets a little murky.

Cornell researchers devised a new method, called tilt-corrected bright-field scanning transmission electron microscopy (tcBF-STEM), to image thick samples with higher contrast and a fivefold increase in efficiency.

The Sept. 23 publication of the findings, in Nature Methods, arrives two years after the death of co-author Lena Kourkoutis, M.S. ‘06, Ph.D. ‘09, associate professor in applied and in Cornell Engineering, whose work in cryo-electron microscopy drove much of the nearly 10-year effort.

Researchers eye bio-hybrid robots with engineered and biological parts for self-healing, energy efficiency

Officials of the U.S. Defense Advanced Research Projects Agency (DARPA) in Arlington, Va., issued an advanced research concepts opportunity earlier this month (DARPA-EA-25–02-02) for the Hybridizing Biology and Robotics through Integration for Deployable Systems (HyBRIDS) program.

Bio-hybrid robotics

Bio-hybrid robotics combines living organisms and synthetic materials to create biorobots that compared to traditional robots can offer adaptability, self-healing, and energy efficiency.

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