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Decoding of amidated aromatic Cterminus and sulfation by cholecystokinin receptors reveals conserved and divergent evolutionary mechanisms

Understanding how evolutionarily related receptors preserve recognition principles for conserved peptide post-translational modifications (PTMs) while acquiring new selectivity remains central to neuropeptide-G protein-coupled receptor (GPCR) biology. The Aplysia cholecystokinin (CCK) system provides an informative model, as its peptides combine two representative PTM-related features: an amidated aromatic C-terminus (RFamide/DFamide), and a dual-tyrosine sulfation pattern exceeding the single-site architecture typical of vertebrates.

Brain-inspired nanopore device uses current-induced heating for memory operations

Some researchers are leaning into biology for inspiration in computing. In particular, neuromorphic computing offers a brain-inspired approach to hardware that replaces traditional binary processing with systems that function more like neurons and synapses. Now, a new study, published in Nature Communications, describes an innovative design for a fluidic memristor that uses its own self-heating mechanism to induce a history-dependent memory effect.

So far, most memristor (memory resistor) devices have used solid materials with electrons or holes functioning as charge carriers. But fluidic memristors instead take advantage of the movement of ions in liquids, which more closely mimics biological signaling, like that which occurs in the brain. However, existing fluidic memristors can be difficult to fabricate and offer a limited range of memory behaviors. The authors of the new study came up with a way to overcome some of these limitations by using temperature fluctuations while also making the device more “brain-like.”

They write, The exploration of additional memristive mechanisms may be beneficial. In conventional integrated circuits, localized heating is generally regarded as an unnecessary and even harmful side effect. However, in biological neural systems, thermal signals are closely linked to essential life processes. They significantly affect neuronal functions, including ion channel activation, action potential conduction speed, and firing patterns.

The invisible wearable: New skin sensors advance health monitoring

While wearable health sensors are becoming increasingly common, current iterations are awkward to wear. For example, devices attached to the face can draw unwanted attention, increase self-consciousness and influence the signals users are trying to measure. However, recent research may have found a solution by introducing ultrathin sensors that cannot be seen by observers or felt by the wearer.

In an article published in Science Advances, researchers from the Institute of Industrial Science, The University of Tokyo, and collaborating institutions reported developing thin, stretchable on-skin electrodes that are effectively invisible when worn on the face. The new technology can measure biological signals while remaining undetectable by eye and touch, allowing monitoring to take place under more natural conditions.

Biosignals such as eye movements, facial muscle activity and brain activity provide valuable information for health care monitoring and human-machine interaction. However, conventional facial electrodes can alter a person’s appearance and affect social interactions, creating what are called appearance artifacts—changes in behavior or psychological state caused simply by wearing a device that the individual and others can see.

Joint trajectories of brain atrophy, white matter hyperintensities and cognition quantify brain maintenance

Joint longitudinal modelling of brain atrophy, white matter damage, and cognition in 543 older adults yielded a brain maintenance index. Poorer mental health, lower openness, and faster biological ageing predicted reduced maintenance.

Scientists Keep Teaching Life to Play Doom, But Why?

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Hello and welcome! My name is Anton and in this video, we will talk about why Doom is used in scientific experiments involving learning.
Links:
https://arxiv.org/pdf/2602.11632
https://corticallabs.com/cl1
• Rats in Doom.
https://theconversation.com/how-scien
#doom #biology #learning.

0:00 Doom runs on everything.
1:03 Brain organoids and why they are used.
2:50 New breakthrough — a biological computer.
3:50 How cells learns to play Doom.
5:10 Rats and Doom.
6:20 Organoids and engineering problems.
7:00 Implications for biology and information sciences.
9:08 Conclusions.

Enjoy and please subscribe.

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Scientists discovered the brain doesn’t make decisions the way we thought

A new study suggests the brain begins making decisions much earlier than scientists previously thought. Researchers found that even primary sensory regions are influenced by higher brain areas through rapid feedback loops, rather than simply passing information forward. This more dynamic view of brain function could help engineers design future AI systems that think more like biological brains while using far less power.

Biodegradation of polyethylene by the marine fungus Parengyodontium album

Year 2024 Marine fungus that eats plastic.


Plastic pollution in the marine realm is a severe environmental problem. Nevertheless, plastic may also serve as a potential carbon and energy source for microbes, yet the contribution of marine microbes, especially marine fungi to plastic degradation is not well constrained. We isolated the fungus Parengyodontium album from floating plastic debris in the North Pacific Subtropical Gyre and measured fungal-mediated mineralization rates (conversion to CO2) of polyethylene (PE) by applying stable isotope probing assays with 13 C-PE over 9 days of incubation. When the PE was pretreated with UV light, the biodegradation rate of the initially added PE was 0.044%/day. Furthermore, we traced the incorporation of PE-derived 13 C carbon into P. album biomass using nanoSIMS and fatty acid analysis.

Optically detected and radio wave-controlled spin chemistry in flavoproteins

An incredible paper by Meng et al. showing how the fluorescence of the flavoproteins iLOV and cryptochrome can be modulated by RF signals when held under certain magnetic fields. This work may provide a foundation for more RF tools which allow manipulation of biological processes.


Radio waves are shown to modulate fluorescence and associate spin chemistry in proteins.

What Makes Information Physical? | Chiara Marletto

What makes information a real part of physics rather than just a way of describing the world?

Chiara Marletto explains how constructor theory grounds information in physical reality, why information is not merely a human concept, and how knowledge differs from information by possessing the ability to persist and shape the world around it.

0:00 Constructor Theory and the Physics of Information 1:49 Is Information Fundamental to Reality? 4:42 Constructor Theory Beyond Quantum Information 6:31 Information, Knowledge, and Resilience 10:17 Why Knowledge Emerges Above Fundamental Physics.

Chiara Marletto is a Research Fellow at Wolfson College, University of Oxford. She holds degrees from the universities of Oxford and Turin. Her main research focus is in theoretical physics, and she also pursues interests in theoretical biology, epistemology, and Italian literature. The Science of Can and Can’t: A Physicist’s Journey Through the Land of Counterfactuals is her first trade book.

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