UniQure’s highly promising Huntington’s disease gene therapy BLA (biologics license application) was rejected by the FDA — because UniQure used an external control rather than a surgical sham control. Yet the latter would put control group patients at additional risk, making it ethically problematic. Hopefully some agreement will be reached which circumvents these issues! For now, it is an educational story to watch unfold.
Abi-Saab said during uniQure’s earnings call that he wouldn’t count on the four-year data altering the FDA’s decision.
“We don’t believe that there’s any reason we have today to believe that this will change the FDA’s position regarding the Phase 1/2 trials,” he told investors.
H.C. Wainwright struck a different tone, however, in the Monday note. “While the FDA appears to be enforcing a full sham surgery-controlled Phase 3 trial in Huntington’s, we believe an alternative path forward may be negotiated given the strong AMT-130 data generated to-date,” the analysts wrote. The 4-year data “should further inform the durability and magnitude of effect observed to date.”
What happens to matter when it’s crushed beyond the point where atoms can exist? Inside a neutron star, the densest visible object in the universe, matter is compressed into states so extreme that physicists still don’t fully understand what’s there.
In this calm long-form space documentary, we take a journey layer by layer through the interior of a neutron star — from the crystalline crust where exotic nuclei form structures unlike anything on Earth, through the bizarre \.
A long time ago I became friends with a guy named Frank White. He was working with president Reagan’s National Commission on Space, and my friend Dave Brody and I were shooting a documentary where we were interviewing some of the Commission members. We hit it off immediately. Fellow O’Neillians all. Since then Frank has become a close buddy and ally in the cause of the Space Revolution. Our styles couldn’t be more different I am the Charge the enemy! guy and he is a gentle, quiet human being. Along the way to the Frontier, he coined the term OverView Effect, as a means of expressing what happens to people when they fly above the MotherWorld and gaze back at her. He nailed it with that one. Dude’s got himself a real-live “meme”! And I couldn’t be happier. So now it’s time to get the man up there so he can get “Effected” himself! The team at MoonDAO are raising funds right now to send this beautiful human into space. You can help! They’ve already raised over $150k! So join in right now and let’s do this thing! Send Frank to Space! Right now! Make a donation! UP!
Want to go to space? Join Frank White and bring the Overview Effect to Earth to help unite humanity.
The past and future are the same thing | feynman on time symmetry.
Discover one of physics’ most mind-bending secrets: the fundamental laws of nature don’t know which way time flows! In this exploration of Feynman’s ideas on time symmetry, we dive deep into how the equations of physics work equally well forwards and backwards, why positrons are electrons moving backward through time, and how the Wheeler-Feynman absorber theory suggests the future might influence the past.
From billiard balls to quantum mechanics, from Maxwell’s equations to the mystery of why we remember yesterday but not tomorrow, this video unravels the beautiful symmetry hidden beneath our everyday experience of time.
Topics Covered: • Time symmetry in fundamental physics • Positrons as electrons traveling backward in time • Wheeler-Feynman absorber theory • The thermodynamic arrow of time • Path integral formulation and quantum mechanics • Why time appears to flow in one direction • CP violation and the weak nuclear force.
Perfect for physics enthusiasts, students, and anyone curious about the nature of time and reality.
⚠️ DISCLAIMER: This is AI-generated content created in the style of Richard Feynman’s teaching approach. The script synthesizes information from various sources about Feynman’s work and ideas in theoretical physics, including his lectures, published papers, and documented contributions to quantum electrodynamics and time-symmetric theories. While based on authentic concepts from Feynman’s career, this is an educational interpretation and not actual recorded material from Richard Feynman.
Life of leonard susskind;leonard susskind physics.
*Description:* Can scientists really simulate a full human brain now? In this video, we explore the latest study claiming that supercomputers may soon be powerful enough to simulate the human brain. We break down how this new method works, why previous brain simulation projects failed, what makes this new research different, and the big ethical questions that come with it. Is this the future of neuroscience and artificial intelligence, or are we still far from creating a true digital human mind? Watch till the end to understand the science in simple words.
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*Keywords with commas:* human brain simulation, simulate human brain, scientists show brain simulation, human brain study, brain simulation study, can we simulate a human brain, supercomputer brain simulation, neuroscience breakthrough, artificial intelligence and brain, digital human brain, full brain simulation, neuron network simulation, brain research latest, new science study, AI and neuroscience, future of brain simulation, latest neuroscience news, exascale supercomputer, Jupiter supercomputer brain, human mind simulation.
What happens when gravity crushes a dead star so completely that atoms themselves are destroyed? Inside a white dwarf, matter enters a state so extreme that the normal rules of physics no longer apply. The familiar categories — solid, liquid, gas — all break down. What holds the star up is not heat, not fusion, not any force you encounter in everyday life. It is a quantum mechanical rule about electrons that most people have never heard of: the Pauli exclusion principle.
In this calming long-form science documentary, we explore what white dwarfs really are, why their matter is millions of times denser than anything on Earth, and how a law governing subatomic particles can hold up an object with the mass of the sun. We break down electron degeneracy pressure in physically intuitive terms, explain why these stellar remnants can cool for trillions of years without ever collapsing, and reveal the Chandrasekhar limit — the critical mass threshold beyond which even quantum mechanics loses its battle against gravity, leading to some of the most violent explosions in the universe.
From the death of sun-like stars to the far future of the cosmos, this is the story of matter pushed to its absolute limit.
That’s no moon. It’s a space station. The enormous, planet-killing kind, designed for only one thing — to bring order to the galaxy. It’s Star Wars’ Imperial superweapon, the Death Star. What would it take to build one just like this? Where would we assemble the biggest weapon of mass destruction?
Transcript and sources: https://insh.world/science/what-if-yo… more what-if scenarios: Planet Earth: • What If Earth Was in Fact Flat? The Cosmos: • Video Technology: • What If the Sahara Desert Was Covered With… Your Body: • What If You Were Born on a Space Station? Humanity: • What If You Were the Last Person on Earth? Tweet us your what-if question to suggest an episode: / whatifscience What If elsewhere: Instagram: / whatif.show Twitter: / whatifscience Facebook: / what.if.science Suggest an episode (detailed): http://bit.ly/suggest-whatif T-shirts and merch: http://bit.ly/whatifstore Feedback and inquiries: https://underknown.com/contact/ What If is a mini-documentary web series that takes you on an epic journey through hypothetical worlds and possibilities. Join us on an imaginary adventure — grounded in scientific theory — through time, space and chance, as we ask what if some of the most fundamental aspects of our existence were different.
Watch more what-if scenarios: Planet Earth: • What If Earth Was in Fact Flat? The Cosmos: • Video. Technology: • What If the Sahara Desert Was Covered With… Your Body: • What If You Were Born on a Space Station? Humanity: • What If You Were the Last Person on Earth?
Tweet us your what-if question to suggest an episode: / whatifscience.
What If elsewhere: Instagram: / whatif.show. Twitter: / whatifscience. Facebook: / what.if.science.
In a cross-sectional study of adults aged 25–49 years in the US, colorectal cancer (CRC) mortality rose from 1994 to 2023, primarily among those with 15 or fewer years of education, and educational disparities in mortality widened over time. More on the study.
Researchers analyze trends in colorectal cancer mortality among adults aged 25–49 years in a study spanning about three decades.
Following thinkers like Aristotle—viewed infinity as a never-ending process rather than a completed object. In the late 19th century, Georg Cantor revolutionized this view by treating infinite sets as mathematical objects that could be compared and studied. His work showed that not all infinities are equal, and that there are infinitely many different sizes of infinity. While his ideas are foundational in modern mathematics, some philosophical schools, such as finitism and ultrafinitism, continue to question whether infinite objects meaningfully exist.
I subscribe to The Economist for their science and tech coverage. As a TOE listener, get 35% off! No other podcast has this: https://economist.com/TOE
A digitally signed adware tool has deployed payloads running with SYSTEM privileges that disabled antivirus protections on thousands of endpoints, some in the educational, utilities, government, and healthcare sectors.
In a single day, researchers observed more than 23,500 infected hosts in 124 countries trying to connect to the operator’s infrastructure, with hundreds of infected endpoints present in high-value networks.
