Scientists have found a nanoparticle-inspired solution to the age-old strength issue of polymer glasses. Seasoning the polymer glass recipe with single-chain nanoparticles, which are tiny, folded-up polymer strands, can make the glass stronger, tougher, and easier to process by acting as reinforcements.
In a study published in Physical Review Letters, researchers from China overcame these issues by using nanoparticles made from balled-up single-chain polymers (SCNPs). According to the researchers, their approach opens a new pathway for creating advanced polymer glasses that combine strength, toughness, and processability in ways previously thought to be incompatible.
Polymer glass, also known as plexiglass, is widely used for making eyeglasses and enclosures for aquariums and museums. For decades, researchers have been seeking ways to enhance the mechanical properties of plexiglass, with a primary focus on improving its strength and toughness.
A team of engineers at the University of Massachusetts Amherst has announced the creation of an artificial neuron with electrical functions that closely mirror those of biological ones. Building on their previous work using protein nanowires synthesized from electricity-generating bacteria, the team’s discovery means that we could see immensely efficient computers built on biological principles which could interface directly with living cells.
“Our brain processes an enormous amount of data,” says Shuai Fu, a graduate student in electrical and computer engineering at UMass Amherst and lead author of the study published in Nature Communications. “But its power usage is very, very low, especially compared to the amount of electricity it takes to run a Large Language Model, like ChatGPT.”
The human body is over 100 times more electrically efficient than a computer’s electrical circuit. The human brain is composed of billions of neurons, specialized cells that send and receive electrical impulses all over the body. While it takes only about 20 watts for your brain to, say, write a story, an LLM might consume well over a megawatt of electricity to do the same task.
Understanding what happens inside a material when it is hit by ultrashort light pulses is one of the great challenges of matter physics and modern photonics. A new study published in Nature Photonics and led by Politecnico di Milano reveals a hitherto neglected but essential aspect, precisely the contribution of virtual charges, charge carriers that exist only during interaction with light, but which profoundly influence the material’s response.
The research, conducted in partnership with the University of Tsukuba, the Max Planck Institute for the Structure and Dynamics of Matter, and the Institute of Photonics and Nanotechnology (CNR-IFN) investigated the behavior of monocrystalline diamonds subjected to light pulses lasting a few attoseconds (billionths of a billionth of a second), using an advanced technique called attosecond-scale transient reflection spectroscopy.
By comparing experimental data with state-of-the-art numerical simulations, researchers were able to isolate the effect of so-called virtual vertical transitions between the electronic bands of the material. Such an outcome changes the perspective on how light interacts with solids, even in extreme conditions hitherto attributed only to the movement of actual charges.
Despite being one of the most familiar substances on Earth, water holds many secrets that scientists are still working to understand. When confined to extremely small spaces—such as within certain proteins, minerals, or artificial nanomaterials—water behaves in ways that are drastically different from its bulk liquid form.
These confinement effects are critical for many natural and technological processes, including regulating the flow of ions through cell membranes and the properties of nanofluidic systems.
One intriguing yet poorly understood state of confined water is called the “premelting state.” In this unique phase, water behaves as if it were on the cusp of freezing and melting at the same time, thus defying simple liquid or solid classifications. However, it has proven difficult to study the premelting state and other confined water dynamics in detail.
Targeting therapeutic nanoparticles to the brain poses a challenge due to the restrictive nature of the blood–brain barrier (BBB). Here we report the development of mRNA-loaded lipid nanoparticles (LNPs) functionalized with BBB-interacting small molecules, thereby enhancing brain delivery and gene expression. Screening brain-targeted mRNA-LNPs in central nervous system (CNS) in vitro models and through intravenous administration in mice demonstrated that acetylcholine-conjugated LNPs achieved superior brain tropism and gene expression, outperforming LNP modifications with nicotine, glucose, memantine, cocaine, tryptophan, and other small molecules. An artificial intelligence (AI)-based model designed to predict the BBB permeability of small-molecule ligands showed strong alignment with our experimental results, providing in vivo validation of its predictive capacity. Cell-specific biodistribution analysis in Cre-reporter Ai9 mice showed that acetylcholine-functionalized LNPs preferentially transfected neurons and astrocytes following either intravenous or intracerebral administration. Mechanistic studies suggest that acetylcholine-LNP uptake is mediated by the functional engagement of acetylcholine receptors (AchRs) followed by endocytosis, which synergistically enhances intracellular mRNA delivery. Moreover, acetylcholine-LNPs successfully crossed a human BBB-on-a-chip model, enabling transgene expression in human iPSC-derived neurons. Their effective penetration and transfection in human brain organoids further support their potential activity in human-based systems. These findings establish a predictive and modular framework for engineering CNS-targeted LNPs, advancing precision gene delivery for brain disorders.
Scientists at Michigan State University have discovered how to use ultrafast lasers to wiggle atoms in exotic materials, temporarily altering their electronic behavior. By combining cutting-edge microscopes with quantum simulations, they created a nanoscale switch that could revolutionize smartphones, laptops, and even future quantum computers.