Blog

Archive for the ‘genetics’ category

Nov 16, 2017

The FDA Just Approved Another Promising Immunotherapy For Cancer

Posted by in categories: biotech/medical, genetics

On Wednesday—for only the second time—the Food and Drug Administration approved a cutting-edge therapy that genetically modifies a patient’s blood cells in order to attack cancer. This time the therapy, known as CAR T-cell therapy, is designed to treat aggressive non-Hodgkin lymphoma.

In August, the FDA approved the first CAR T-cell therapy, for a drug called Kymriah designed for children and young adults whose leukemia doesn’t respond to standard treatments. The FDA’s approval of Yescarta, manufactured by Kite Pharma, comes just a few months after its first approval—an indication of just how quickly the field of immunotherapy is moving. Several other companies also have CAR-T therapies in the works.

Read more

Nov 15, 2017

Regeneration of the entire human epidermis using transgenic stem cells

Posted by in categories: biotech/medical, genetics

[p]Patients with junctional epidermolysis bullosa (JEB) carry mutations in genes that encode components of the basement membrane, which ensures the integrity between the epidermis and the dermis, such as laminin-332. These mutations cause blistering of the skin and chronic wounds. Following initial treatment of an adult patient with a limited affected region, Michele De Luca and colleagues reconstruct the full epidermis of a 7-year-old patient with autologous transgenic cells transduced with a virus vector carrying the non-mutated form of laminin-322.

Read more

Nov 15, 2017

AP Exclusive: US scientists try 1st gene editing in the body

Posted by in categories: bioengineering, biotech/medical, genetics

For the first time ever, scientists have attempted to cure a person’s disease by editing a gene inside the body.

Scientists used an IV to inject a patient with billions of copies of a corrective gene and a genetic tool to cut his DNA in a specific spot. “We cut your DNA, open it up, insert a gene, stitch it back up.”

Scientists have edited people’s genes in the past, but that work involved altering cells inside a lab and then returning them to the body, whereas the latest experiment was performed inside a person’s body.

Continue reading “AP Exclusive: US scientists try 1st gene editing in the body” »

Nov 15, 2017

Doctors are gene editing inside the body of a living human for the first time

Posted by in categories: bioengineering, biotech/medical, genetics, neuroscience

He is the first patient to receive an experimental gene therapy as part of a clinical trial. Earlier this week, Sangamo Therapeutics injected Madeux with viruses containing a package of gene-editing material, according to the AP. The hope is that these viruses will enter Madeux’s cells, specifically liver cells, inject the missing gene at the right place in his DNA. Only about 1% of the liver’s cells need to be fixed, and give his liver the ability to produce the enzyme he has been missing all his life.


Brian Madeux’s life hasn’t been easy. So far, he’s had 26 operations to fix problems in everything from hernias to eyes. He has a rare disease called Hunter syndrome, which is caused by the lack of a gene that’s used to produce an enzyme that breaks down certain carbohydrates. As a result, the carbohydrates build up in his body’s cells causing all sorts of problems.

Continue reading “Doctors are gene editing inside the body of a living human for the first time” »

Nov 15, 2017

Gene Therapy for Blindness May Soon Be Reality

Posted by in categories: biotech/medical, genetics

The success of a novel gene therapy for blindness caused by a genetic mutation paves the way for gene therapies which treat other forms of blindness as well as genetic therapies which treat other diseases.


After being treated with a novel gene therapy for blindness, patients who had lost their sight due to a genetic retinal disease could see well enough to navigate a maze, according to research presented today at the 2017 Annual Meeting of the American Academy of Ophthalmology (AAO 2017).

Novel Gene Therapy for Blindness

Continue reading “Gene Therapy for Blindness May Soon Be Reality” »

Nov 4, 2017

‘Chemical surgery’ can correct genetic mutations behind many diseases – study

Posted by in categories: biotech/medical, genetics

“Scientists are hopeful that the approach could offer new ways to understand – and even one day tackle – certain human genetic diseases by correcting mutations in a patient’s body.”


Fresh DNA base editing breakthrough brings hope of potential treatment for huge number of diseases that arise as a result of a single genetic ‘misspelling’.

Read more

Nov 3, 2017

Gene editing and beyond

Posted by in categories: bioengineering, biotech/medical, genetics

The CRISPR-Cas9 system has revolutionised gene-editing, but cutting DNA isn’t all it can do. From turning gene expression on and off to fluorescently tagging particular sequences, this animation explores some of the exciting possibilities of CRISPR.

Download a poster on ‘The expanding CRISPR toolbox’ here: https://www.nature.com/posters/crisprtoolbox

Continue reading “Gene editing and beyond” »

Oct 31, 2017

Gene-editing tool CRISPR can now manipulate more types of genetic material

Posted by in categories: biotech/medical, genetics

‘It’s another tool in the toolbox’

Read more

Oct 29, 2017

New CRISPR tools enable extraordinarily precise gene editing in human cells

Posted by in categories: bioengineering, biotech/medical, food, genetics

Over just a few short years the CRISPR gene-editing technique has revolutionized science, affecting everything from medicine to agriculture. Two new breakthrough studies have just been published describing dual methods that make the process more precise and efficient paving the way for scientists to safely alter DNA mutations that cause thousands of different human diseases.

CRISPR is conventionally a cut-and-paste tool allowing scientists to chop out unwanted strands of DNA and insert new genes, but a large volume of human diseases are caused by a single point mutation somewhere in a person’s DNA. Up until now scientists have not been able to simply and directly erase or rewrite these single mutations in living human cells.

Our human genome consists of 3 billion base pairs made up of chemical units referred to by the letters A, C, G and There are 50,000 known genetic mutations that are linked to disease in humans and 32,000 of these are single point mutations. Half of those single point mutations have been identified as a G-C pair that has mutated into an A-T pair.

Continue reading “New CRISPR tools enable extraordinarily precise gene editing in human cells” »

Oct 27, 2017

Researchers create new ‘letters’ to enhance DNA functions

Posted by in categories: bioengineering, biotech/medical, genetics, nanotechnology

Just like how letters are strung together to form words, our DNA is also strung together by letters to encode proteins. The genetic alphabet contains only 4 natural letters — A, C, G and T, which hold the blueprint for the production of proteins that make our bodies work. Now, researchers from the Institute of Bioengineering and Nanotechnology (IBN) of the Agency for Science, Technology and Research (A*STAR) have created a DNA technology with two new genetic letters that could better detect infectious diseases, such as dengue and Zika.

Genetic alphabet expansion technology is the introduction of artificial base pairs into DNA. The existing four genetic letters are naturally bound together in base pairs of A-T and G-C. These specific base pair formations are essential in DNA replication, which occurs in all living organisms. It is the process by which a DNA molecule is duplicated to produce two identical molecules.

“The expansion of the genetic alphabet is a significant scientific achievement. It sheds insights into DNA’s natural replication mechanism, which will help us to design unique DNA molecules and technologies. For example, our technology can be used to create novel diagnostics and therapeutic agents with superior efficacy,” said IBN Executive Director Professor Jackie Ying.

Continue reading “Researchers create new ‘letters’ to enhance DNA functions” »

Page 1 of 7412345678Last