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Category: genetics – Page 4

A new study published in Nature reveals how olfactory sensory neurons (OSNs) achieve extraordinary precision in selecting which genes to express.

The mechanism is surprising in that it involves solid-like molecular condensates that last for days, helping to solve a long-standing puzzle in genome organization.

The research, led by Prof. Stavros Lomvardas from Columbia University, addresses one of biology’s most intriguing questions: How do in the nose manage to express only one (OR) gene out of approximately 1,000 available options?

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A new study, led by San Diego Zoo Wildlife Alliance, Smithsonian’s National Zoo & Conservation Biology Institute, and additional researchers, offers a unique lens for understanding the unprecedented extinction crisis of native Hawaiian forest birds.

Just 17 out of approximately 60 species of the iconic honeycreeper remain, most of which are facing due to avian malaria. The findings, published in Current Biology, include new evidence that there is still time to save the critically endangered honeycreeper ‘akeke’e—but the window is rapidly closing.

“In a race against time to save the remaining honeycreepers, necessary insights about their survival are found in their ,” said Christopher Kyriazis, Ph.D., lead author and postdoctoral researcher from San Diego Zoo Wildlife Alliance. “Our findings provide a new understanding of the last remaining individuals as recovery efforts forge on in their native forests and in human care.”

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Long-read sequencing technologies analyze long, continuous stretches of DNA. These methods have the potential to improve researchers’ ability to detect complex genetic alterations in cancer genomes. However, the complex structure of cancer genomes means that standard analysis tools, including existing methods specifically developed to analyze long-read sequencing data, often fall short, leading to false-positive results and unreliable interpretations of the data.

These misleading results can compromise our understanding of how tumors evolve, respond to treatment, and ultimately how patients are diagnosed and treated.

To address this challenge, researchers developed SAVANA, a new algorithm which they describe in the journal Nature Methods.

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Researchers have uncovered that some childhood cancers have a substantially higher number of DNA changes than previously thought, changing the way we view children’s tumors and possibly opening up new or repurposed treatment options.

Concentrating on a type of childhood kidney cancer, known as Wilms tumor, an international team genetically sequenced multiple tumors at a resolution that was previously not possible.

This collaboration included researchers at the Wellcome Sanger Institute, University of Cambridge, Princess Máxima Center for Pediatric Oncology, the Oncode Institute in the Netherlands, Great Ormond Street Hospital, and Cambridge University Hospitals NHS Foundation Trust.

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Genetic studies can offer powerful insights for the development of disease-modifying therapies for Alzheimer’s disease. Protective genetic variants that delay the onset of cognitive impairment have been found in people with sporadic Alzheimer’s disease and in carriers of mutations that usually cause autosomal-dominant Alzheimer’s disease in mid-life. The study of families who carry autosomal dominant mutations provides a unique opportunity to uncover genetic modifiers of disease progression, including rare variants in genes such as APOE and RELN.

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Tête de Moine, a semi-hard Swiss cheese that often finds its way onto charcuterie boards and salads, not only brings a rich, nutty and creamy flavor, but also adds a dramatic flare to the presentation. Instead of slicing, this cheese is shaved into delicate rosettes using a tool called a Girolle whose rotating blade gently scrapes thin layers of cheese into ruffled curls. These pretty cheese flowers are known to enhance the flavor and texture due to their high surface-to-volume ratio.

The unusual way Tête de Moine forms wrinkles when shaved, piqued the interest of a team of physicists who, in a study published in Physical Review Letters, set out to investigate the physical mechanisms behind these intricate shapes.

Similar morphogenetic patterns can be observed in the frilly edges of leaves, fungi, corals, or even torn , but the mechanisms that explain the similar shapes in these materials fail to account for the distinctive physical properties of .

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Scientists have uncovered a critical role for rapid DNA repair in maintaining genome stability. A new study reveals that repair of double-strand breaks (DSBs) in nuclear DNA in plants serves as a powerful safeguard against the integration of foreign DNA from chloroplasts—a phenomenon that, while important for evolution, can be highly destabilizing to the genome. The research expands our knowledge about plant genome evolution and also has relevance to the medical field.

The findings, presented by Dr. Enrique Gonzalez-Duran and Prof. Dr. Ralph Bock from the Max Planck Institute of Molecular Plant Physiology in Nature Plants, shed new light on endosymbiotic gene transfer (EGT)—an ongoing evolutionary process in which genes from organelles such as chloroplasts and mitochondria are relocated into the nuclear genome.

While successful gene transfers help the nucleus to better coordinate its function with that of the organelles, they also pose risks: Mutations arising from DNA insertion can disrupt essential nuclear genes and provoke harmful rearrangements.

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The boundaries of computing are shifting as biology fuses with technology. At the center of this new frontier is an emerging concept: a liquid computer powered by DNA. With the ability to support more than 100 billion unique circuits, this system could soon transform how we detect and diagnose disease.

While DNA is best known for encoding life, researchers are now exploring its potential as a computing tool. A team led by Dr. Fei Wang at Shanghai Jiao Tong University believes DNA can do much more than carry genetic instructions.

Their study, recently published in Nature, reveals how DNA molecules could become the core components of new computing systems. Rather than just holding genetic data, DNA could behave like wires, instructions, or even electrons inside biological circuits.

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As researchers work to improve treatment of Alzheimer’s disease, new research by UCLA Health identified a candidate drug that reduces levels of a toxic form of a protein in the brain caused by the disease and improved memory in mice by boosting production of a protective protein.

In a study published in npj Drug Discovery, UCLA Health researchers targeted the protein clusterin (CLU), which is crucial in preventing the build-up of amyloid-beta plaques and tau proteins that disrupt communication between and lead to memory impairment—a hallmark symptom of Alzheimer’s disease.

More than a decade ago, a variant of the gene that encodes clusterin was identified as the third strongest genetic risk factor for late-onset Alzheimer’s disease. It was recently reported that increased CLU protein could provide protection against Alzheimer’s disease and .

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