Lifeboat Foundation

The latest episode of the Huberman Lab Podcast is all about the aging process and how to slow, halt or reverse it. My guest is Dr. David Sinclair from Harvard Medical School.

We discuss:

• Epigenetics.
• Fasting, breaking fasts.
• Nutrition, artificial sweeteners.
• How puberty impacts aging.
• Resveratrol, caffeine, electrolytes.
• NAD, NMN, Metformin, Berberine.
• Specific supplementation protocols.

Genetically modified crops have a bad rep. How could something so unnatural be good for us?

Well, we finally get to hear from the plants themselves. New evidence shows that plants have been genetically modifying themselves — and the process, called lateral gene transfer, could lead to new plants that are resilient to climate change.

The research: We all know that genes are transferred from parent to offspring. The same is true for all species, including plants. Some bacteria can swap genes with each other, but more complex life (usually) stays in its lane.

The idea that our genes are our fate” is dead. Exciting new discoveries in the field of epigenetics have proven that our lifestyle and environment can turn off and on many of the genes that control our health and wellbeing. Simple things like where we live, what we eat, pollution, stress, and exercise all impact which genes are silenced and expressed throughout our lives.

Research has shown that that the current dramatic rise in obesity, heart disease, diabetes and Alzheimer’s all have epigenetic mechanisms at play. Not only that but many epigenetic changes are actually passed to future generations: your grandmother’s dietary deficits may have caused your diabetes. Your father’s smoking may have turned on your marker for obesity or ADHD. Three generations later the descendants of holocaust survivors are still suffering stress disorders.

Continue reading “Why Are We Genetically Modifying Humans? | Epigenetics | Spark” »

Cardiff University study is ‘major step forward’ in hunt for developmental origins of schizophrenia and other psychiatric disorders.

Scientists from Cardiff University have discovered new links between the breakdown in brain cell development and the risk of schizophrenia and other psychiatric disorders.

Genetic risk factors are known to disrupt brain development in a number of these disorders, but little is known about which aspects of this process are affected.

Continue reading “New Links Discovered Between Brain Cell Development and Psychiatric Disorders — ‘Major Step Forward’” »

Opinions: Give your opinions in the comments section.

3D printed lab meat, and plant based meats will be more widespread in our future. Would you eat stem cell 3D printed lab meat or plant based meat? Why or why not? What are the differences between natural vs unnatural. Growing up in Texas I know most Texans frown on it, as BBQ is a religion. Is 3D printing meat sustainable\.

Whether it comes from a plant or the cells of an animal, it’s becoming increasingly clear that the meat of the future will probably not be coming from the flesh of slaughtered animals. Instead, whether made from plants or cells, it will be formed into ‘meat’ by a 3D printer. In September of 2021, a Japanese team of researchers at the University of Osaka announced that they had 3D printed Wagyu beef. Beef connoisseurs will recognize the name; Wagyu beef is prized (and suitably priced) for its flavor and fat marbling. Legends abound about the cows such beef derives from, how they are allegedly coddled and massaged, fed a special diet that includes beer — but much of those tales are either exaggerated or pure urban legend. As Joe Heitzeberg, the co-founder and CEO of Crowd Cow explains, There are four breeds native to Japan. Of those four breeds, one of the breeds is genetically unique. It has a genetic predisposition to create this crazy marbling of fat on the inside of muscle tissue. No other livestock does that. The researchers at the University of Osaka used two different types of stem cells from Wagyu cows to create cultured meat, growing living animal cells onto some type of matrix where they are then incubated and grown into animal tissue that has never been part of a living animal. There are currently no reports on the taste of the cultured Wagyu beef but we can assume it’s ‘good’ and given a little time, the technology should be able to produce excellent Wagyu cultured meat — at what price, however, is another big question mark. But there’s another simpler solution that could be a better meat replacement than cultured meat, as even meat grown from stem cells still contains cholesterol and some of the negative health concerns associated with animal protein. Plant-based imitation meat is also being created with 3D printers, and the results are surprising even hardcore meat lovers.

Continue reading “Staking a Claim on the Steak of Tomorrow: 3D Printing Tech is Making ‘Meat’” »

In a first, U.S. surgeons transplant pig heart into human patient.

Unusual opportunity

Last week’s procedure marks the first time that a pig organ has been transplanted into a human who has a chance to survive and recover. In 2021, surgeons at New York University Langone Health transplanted kidneys from the same line of genetically modified pigs into two legally dead people with no discernible brain function. The organs were not rejected, and functioned normally while the deceased recipients were sustained on ventilators.

Continue reading “First pig-to-human heart transplant: what can scientists learn?” »

Gene editing approaches promise to treat a range of diseases, but delivering editing agents to cells in animal models and humans safely and efficiently has proven challenging. Now, researchers led by a team at the Broad Institute of MIT and Harvard have developed a way to get gene editing proteins inside cells in animal models with high enough efficiency to show therapeutic benefit.

In new work published in Cell, the team shows how they have engineered virus-like particles to deliver base editors — proteins that make programmable single-letter changes in DNA — and CRISPR-Cas9 nuclease, a protein that cuts DNA at targeted sites in the genome. In collaboration with ​​research teams led by Krzysztof Palczewski at the University of California, Irvine, and Kiran Musunuru at the Perelman School of Medicine at the University of Pennsylvania, the team used their particles, called engineered virus-like particles (eVLPs), to disable a gene in mice that can be associated with high cholesterol levels, and partially restored visual function to mice harboring a mutation that causes genetic blindness.

Researchers have developed virus-like particles that deliver therapeutic levels of protein to animal models of disease.

Continue reading “Engineered particles efficiently deliver gene editing proteins to cells in mice” »

In a world medical first, a 57-year-old patient with terminal heart disease received a successful transplant of a genetically-modified pig heart and is still doing well four days later.

A study published by researchers at the University of Illinois Chicago describes a new method for analyzing pyroptosis–the process of cell death that is usually caused by infections and results in excess inflammation in the body–and shows that process, long thought to be irreversible once initiated, can in fact be halted and controlled.

The discovery, which is reported in Nature Communications, means that scientists have a new way to study diseases that are related to malfunctioning cell death processes, like some cancers, and infections that can be complicated by out-of-control inflammation caused by the process. These infections include sepsis, for example, and acute respiratory distress syndrome, which is among the major complications of COVID-19 illness.

Pyroptosis is a series of biochemical reactions that uses gasdermin, a protein, to open large pores in the cell membrane and destabilize the cell. To understand more about this process, the UIC researchers designed an “optogenetic” gasdermin by genetically engineering the protein to respond to light.

Continue reading “Scientists uncover new information about cellular death process, previously thought to be irreversible” »