Languages and human DNA both capture aspects of human diversity. But how are they related? A new international study led by the University of Zurich finds a clear but counterintuitive pattern: regions with high genetic diversity tend to have more similar languages, while isolated populations with low genetic diversity show greater linguistic diversity. The research is published in the journal Proceedings of the National Academy of Sciences.

At first glance, the findings seem surprising. One might expect regions with greater genetic diversity, often shaped by migration and population mixing, to also show greater diversity in language. But the study reveals the opposite.

“We were struck by how robust this inverse relationship is across the globe,” says Anna Graff, lead author of the study and linguist at the University of Zurich. “Places where people have mixed more tend to be genetically diverse, but their languages are structurally more similar. In contrast, places with long-term isolation show less genetic diversity, yet much greater diversity in how languages are structured. Crucially, this relationship holds after adjusting for a wide range of confounding factors, including deep population history such as the timing of continental settlement.”

Researchers at Aarhus University have demonstrated that a simple adjustment to water filtration methods can dramatically improve the detection of marine animal DNA when using advanced, PCR-free sequencing. This methodological optimization could help clear a major bottleneck in aquatic biomonitoring and marine conservation efforts. The study is published in Metabarcoding and Metagenomics.

Over the past two decades, environmental DNA (eDNA) analysis has become a crucial tool for monitoring aquatic ecosystems. The most common method, metabarcoding, relies on PCR amplification of a smaller genetic region to identify specific taxa. However, PCR can lead to “significant taxonomic bias” because it often amplifies the DNA of different organisms unequally, making quantitative estimates difficult.

To avoid this, scientists have increasingly explored “shotgun sequencing”—a broad approach that sequences the DNA in a sample much more broadly—across the entire tree of life and across the genome.

A blood cancer-protective inherited variant in the homeotic lncRNA HOTSCRAMBL alters HOXA9 splicing, fine-tuning hematopoietic stem cell self-renewal while constraining HOXA-driven blood cancers.