Lifeboat Foundation

Fanconi anemia is rare genetic disorder that can be caused by changes in the sequence of one of at least 22 different genes. The disease can lead to a variety of symptoms including bone marrow failure, skeletal abnormalities, and increases the risk of cancer in patients. Scientists have long thought that the disease is due to problems with DNA that cause cell death, and disruptions in blood stem cells (also known as hematopoietic stem cells (HSCs), which are crucial for constantly replenishing the body’s supply of blood cells.

When protein-coding genes are expressed, the proteins they encode for start out as strings of amino acids, which have to be properly folded into a three-dimensional shape, or else serious problems can arise. Scientists have now determined that a buildup of miscoded proteins is actually a root cause of Fanconi anemia, and that a bile acid may be useful as a new treatment for the disorder. The research has been reported in Nature Communications.

Featuring research from the Doudna laboratory, the University of Harvard and the Center for Advanced Bioenergy and Bioproducts Innovation, this round-up piece discusses the latest research advancements in CRISPR technology.

Every day, our cells are hard at work multiplying. Cell division is a precise process, but sometimes this process is impaired and diseases like cancer occur. Mitosis is one of the most important phases in the cell cycle. During this phase, a cell’s DNA is split into two equal sets of chromosomes and it divides into two genetically identical daughter cells.

Scientists have long pondered the beginnings of life on Earth. One theory is that RNA, which is ubiquitous across all domains of life, played a central role in early life. Similar to DNA, RNA possesses the ability to store genetic information. However, to initiate life’s processes, early RNA must have also possessed the capability to self-replicate and catalyze biochemical reactions independently, without the assistance of specialized enzymes.

Here’s a new Forbes review by world leading futurist Tracey Follows on the book: Transhuman Citizen:

What does Transhumanism, Ayn Rand and the U.S. Presidential election have in common? They are the connecting themes in a new book by Ben Murnane entitled, “Transhuman Citizen”

The book tells the story of Zoltan Istvan, a one-time U.S. Presidential candidate, who drove a coffin-shaped bus around the U.S. attempting to persuade the public that death is not inevitable and that transhumanism is a political as much as a scientific solution to the troubles of the 21st Century.

Continue reading “Can Transhumanism Rescue The West From The Threat Of AI?” »

A clinical trial led by researchers at Washington University School of Medicine in St. Louis has shown that a T cell immunotherapy—in which the patients’ own T cells are genetically modified to attack and kill cancer cells—is effective in treating some patients with rare cancers of the body’s soft tissues.

“The increases in THC levels found in cannabis could mimic some of the more pronounced effects that we see for people who are slower metabolizers,” said Dr. Christal Davis.

How can genetics influence cannabis consumption? This is what a recent study published in Addictive Behaviors hopes to address as a team of researchers investigated a link between how genetic variances influence how a person metabolizes THC, which could not only determine future use but also the chances of succumbing to cannabis use disorder, or CUD. This study holds the potential to help cannabis users, medical professionals, legislators, and the public better understand the physiological influences of cannabis use, even at the molecular level.

For the study, the researchers enlisted 54 participants between 18–25 years of age, 38 of whom suffered from CUD while the remaining 16 suffered from non-CUD substance abuse. It has been determined that individuals aged 18–25 have a three times greater likelihood of having CUD compared to individuals over the age of 26. After obtaining blood samples from each participant, the researchers tested them for differences in gene markers, specifically pertaining to THC-metabolizing enzymes. Additionally, each participant was instructed to fill out a questionnaire regarding their experiences with cannabis use and how it makes them feel when they use it.

Continue reading “Genetic Variants and Cannabis: Unraveling Risk Factors for CUD” »

Whether through genetics or training, scientists say, even mere mortals can develop extraordinary abilities.

In a groundbreaking study led by Dr. Karen Fitzgerald, six women between the ages of 45 and 65 experienced a remarkable reduction in their biological age by an average of five years in just eight weeks. The findings offer promising insights into the potential of lifestyle changes to combat aging.

The study, which focused on the distinction between chronological age and biological age, revealed that while chronological age remains fixed, biological age — the age of one’s cells — can be influenced and even reversed through targeted interventions.

Using Dr. Steven Horvath’s epigenetic clock, which measures 353 markers associated with methylation changes linked to aging, the researchers assessed the participants’ biological age before and after the intervention.