A fundamental desideratum of AI is the ability to model environment dynamics and transitions in response to both their own actions and external control signals. This capability, commonly referred to as world modeling (WM), is essential for prediction, planning, and generalization. Learning world models using deep learning has been an active area of research for nearly a decade. In recent years, the field has witnessed significant breakthroughs driven by advances in deep neural architectures and scalable learning paradigms. Multiple subfields, including self-supervised learning (SSL), generative modeling, reinforcement learning (RL), robotics, and large language models (LLMs), have tackled aspects of world modeling, often with different tools and methodologies. While these communities address overlapping challenges, they frequently operate in isolation. As a result, insights and progress in one area may go unnoticed in another, limiting opportunities for synthesis and collaboration. This workshop aims to bridge this gap between subfields of world modeling by fostering open dialogue, critical discussion, and cross-disciplinary exchange. By bringing together researchers from diverse backgrounds, from early-career researchers to established experts, we hope to establish a shared vocabulary, identify common challenges, and surface synergies that can move the field of world modeling forward.
Category: innovation
ABCA1 protein releases molecular brakes on solid tumor immunotherapy, study finds
In recent years, cancer researchers have made major breakthroughs by using the body’s immune system to fight cancer. One of the most promising approaches, known as immune checkpoint blockade, works by releasing molecular “brakes” on T cells. This allows them to better recognize and attack cancer cells. While these therapies can be very effective for some patients, many solid tumors, including most forms of breast cancer, remain largely unaffected. Cancer Center at Illinois (CCIL) Program Co-leader Erik Nelson and his research group are working to understand why these treatments fail.
Elevated blood concentrations of cholesterol have long been linked to cancer outcomes. In a new study, they found that a protein called ABCA1 is involved in transporting cholesterol out of a type of immune cell called macrophages, and in so-doing shifts them to an “attack cancer” mode.
“Immune based therapies have revolutionized how we can treat cancer, basically taking the brakes off of a type of immune cell called T cells so they can attack cancer,” Nelson said. “While this approach works well for some patients, many so-called solid tumors fail to respond or develop resistance mechanisms.”
Breakthrough: Scientists Created a ‘Universal’ Kidney To Match Any Blood Type
After a decade of work, researchers are closer than ever to a key breakthrough in kidney transplants: being able to transfer kidneys from donors with different blood types than the recipients, which could significantly speed up waiting times and save lives.
In research published last year, a team from institutions across Canada and China reported creating a ‘universal’ kidney that, in theory, can be accepted by any patient.
Their test organ survived and functioned for several days in the body of a brain-dead recipient, whose family consented to the research.
Ultra-thin metasurface chip turns invisible infrared light into steerable visible beams
The invention of tiny devices capable of precisely controlling the direction and behavior of light is essential to the development of advanced technologies. Researchers at the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) have taken a significant step forward with the development of a metasurface that can turn invisible infrared light into visible light and aim it in different directions—without any moving parts. The details of their work are explained in a paper published in the journal eLight.
The novel metasurface is constructed of an ultra-thin chip patterned with tiny structures smaller than the wavelength of light. When hit with an infrared laser, the chip converts the incoming light to a higher color (or frequency) and sends the new light out as a narrow beam that can be steered simply by changing how the incoming light is polarized.
In their experiments, the team converted infrared light around 1,530 nanometers—similar to the light used in fiber-optic communications—into visible green light near 510 nanometers and steered it to chosen angles.
17 Month Life Extension Headed to Human Trial!
New preprint reports 17-month lifespan extension in mice with some living nearly 5 years. The intervention targets immune aging through CD4+ T cells and is expected to enter human trials in 2026.
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A new preprint by Lanna et al. reports one of the largest lifespan extensions ever seen in mice; approximately 17 months, with some mice living close to 5 years. The study focuses on metabolically reprogramming CD4+ T cells from aged mice using a peptide called DOS, which enables these cells to produce \.
Using complex networks to tame combustion instability
Engineers have long battled a problem that can cause loud, damaging oscillations inside gas turbines and aircraft engines: combustion instability. These unwanted pressure fluctuations create vibrations so intense that they can cause fatal structural damage to combustor walls, posing a serious threat in many applications. Combustion instability occurs when acoustic waves, heat release, and flow patterns interact in a strong feedback loop, amplifying each other until the entire system becomes unstable.
The complex interaction has made it difficult to predict when and where dangerous oscillations will emerge. This challenge has motivated researchers to seek new analytical frameworks that can capture the key driving regions of combustion instability.
Now, a research team led by Professors Hiroshi Gotoda from Tokyo University of Science and Ryoichi Kurose from Kyoto University, Japan, has developed an innovative approach using network science to understand and suppress combustion instability. Their paper, published in the journal Physical Review Applied on July 1, 2025, applies complex network analysis to spray combustion instability in a backward-facing step combustor.
Enterprise Spotlight: Manufacturing Reimagined
Emerging technologies from AI and extended reality to edge computing, digital twins, and more are driving big changes in the manufacturing world.
Download the February 2026 issue of the Enterprise Spotlight from the editors of CIO, Computerworld, CSO, InfoWorld, and Network World and learn about the new tech at the forefront of innovation and how it is poised to reshape how companies operate, compete, and deliver value in a rapidly evolving digital landscape.
Interstellar Travel: Approaching Light Speed
Is interstellar travel doomed to remain in the realm of science fiction? Sticking to near future space propulsion only, how close can we get to the speed of light?
This video looks at the current spacecraft speed records with Apollo 10 holding the record for the fastest manned spacecraft, New Horizons probe for the fastest Earth escape velocity and the Helios probes for the fastest heliocentric velocity. But Solar Probe Plus will beat that when it launches in 2018. While Voyager 1 doesn’t set any speed records, it was the first spacecraft to leave the solar system, so therefore the fastest solar system escape velocity by default.
For beating these speeds, this video explores what is possible in the near future only, so no antimatter, Alcubierre drives (warp), ramjets, etc… The EM drive is left out until it’s proven with actual reproducible results in space.
Project Daedalus and the updated Project Icarus represent sound concepts for fusion spacecraft. IKAROS was the first successful demonstration of solar sail technology but hopefully the planetary society is not far behind with their LightSail cubsat (not covered in this video).
But what appears to have the most potential to reach the nearest star to our own, Proxima Centauri and it’s newly discovered planet Proxima b is Breakthrough Starshot. Thousands of super lightweight laser sail nanocraft will be launched into space then the light beamer, a ground based laser array will propel these spacecraft to 20% light speed within minutes.
All sources used in researching this video are listed in the end credits.
Current and emerging therapeutic landscape for metabolic dysfunction-associated steatohepatitis
Globally, metabolic dysfunction-associated steatotic liver disease (MASLD) is now the most common chronic liver disease, affecting up to one in three people in the general population, with an estimated increase in prevalence of more than 50% in the last three decades. The rise in prevalence of MASLD will result in substantial increases in the number patients with decompensated cirrhosis and those developing liver cancer by 2030. Despite the complex pathobiology of MASLD, two major breakthroughs in phase 3 clinical trials now herald an era of licensed therapies for MASLD.