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While studying the effect of various cytotoxic natural products on different cancer cells, the researchers have discovered a previously unknown mechanism that could point to new therapeutic options in the event of such resistance.

“When the cancer cells come into contact with the active substance, they show a stress reaction. Even at this very early stage, long before they might possibly die, reduced growth signals cause increased levels of polyunsaturated fatty acids to be incorporated into the membrane. This makes them more susceptible to a particular cell death pathway, ferroptosis,” explains the researcher, adding: “The mechanism appears to be universal. This means that it can be observed in all the cancer cells examined and in most cytotoxic agents.” During ferroptosis, polyunsaturated fatty acids in cell membranes are damaged by oxygen radicals. The membranes become porous and the cell dies.

These findings create a basis for the systematic research of innovative treatment strategies for therapy-resistant tumors. Even if conventional chemotherapeutic agents do not kill the cells, they at least trigger a membrane change that can be utilized. “By adding substances that induce ferroptosis, cancer cells could ultimately be eliminated completely,” the author suspects.


One particular challenge in the treatment of cancer is therapy resistance. An international research team has now discovered a mechanism that opens up new treatment strategies for tumors in which conventional chemotherapeutic agents have reached their limits.

“Cytotoxic agents from nature lead to an increased incorporation of polyunsaturated fatty acids into the membrane of cancer cells. This makes them more susceptible to ferroptosis, a type of cell death, at a very early stage,” reports the lead author of the study, which has just been published in the scientific journal Nature Communications.

In the treatment of cancer with chemotherapy, natural substances, such as those from the Chinese “happy tree”, play an important role. They interfere with vital cell processes and thereby damage them. However, a few cancer cells are often able to adapt to these challenges and survive. This is called resistance.

Marking a breakthrough in the field of brain-computer interfaces (BCIs), a team of researchers from UC Berkeley and UC San Francisco has unlocked a way to restore naturalistic speech for people with severe paralysis.

This work solves the long-standing challenge of latency in speech neuroprostheses, the time lag between when a subject attempts to speak and when sound is produced. Using recent advances in artificial intelligence-based modeling, the researchers developed a streaming method that synthesizes brain signals into audible speech in near-real time.

As reported in Nature Neuroscience, this technology represents a critical step toward enabling communication for people who have lost the ability to speak.

Adeno-associated virus (AAV) is a prominent method for delivering genes in vivo. Therapeutic delivery to target cells is achieved through full capsids containing the gene cargo. However, the presence of empty capsids in the AAV drug product can reduce therapeutic effectiveness, necessitating their detection at various stages of the AAV production process. Traditional methods for assessing the AAV empty/full (E/F) ratio are often slow, labor-intensive, and require significant optimization.

Consider a novel, rapid, and high-throughput approach for determining the AAV E/F ratio using Octet® Biolayer Interferometry (BLI) alongside Octet® AAVX Biosensors. This cutting-edge technique evaluates intact viral capsids and is perfect for screening both crude and purified samples, offering a quicker and more efficient workflow with results available in as little as 30 minutes.

Discover the advantages of this innovative method and enhance your AAV workflow by downloading the technical note.

In a remarkable leap forward for science, researchers at CERN have successfully created and observed top quarks—one of nature’s most elusive and unstable particles—inside a lab for the very first time. This breakthrough, announced by the ATLAS team at the Large Hadron Collider (LHC), promises to reshape our understanding of the early Universe and the fundamental makeup of matter.

Thanks to breakthroughs in hydrogel material science, we now have material that functions similar to Star Wars Bacta.

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“Tribhuvan” Sahkari University, through its innovative HUB-and-SPOKE model, will ensure nationwide reach and accessibility by integrating sectoral schools and leveraging strategic partnerships to build a robust Pan-India ecosystem of technical and skill development institutions.

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Pedestrian crossings generally showcase the best in pedestrian behavior, with people naturally forming orderly lanes as they cross the road, smoothly passing those coming from the opposite direction without any bumps or scrapes. Sometimes, however, the flow gets chaotic, with individuals weaving through the crowd on their own haphazard paths to the other side.

Now, an international team of mathematicians, co-led by Professor Tim Rogers at the University of Bath in the UK and Dr. Karol Bacik at MIT in the US has made an important breakthrough in their understanding of what causes human flows to disintegrate into tangles. This discovery has the potential to help planners design road crossings and other pedestrian spaces that minimize chaos and enhance safety and efficiency.

In a paper appearing in the journal Proceedings of the National Academy of Sciences, the team pinned down the precise point at which crowds of pedestrians crossing a road collapse from order to disorder.

When University of Texas at Dallas researchers tested a new surface that they designed to collect and remove condensates rapidly, the results surprised them. The mechanical engineers’ design collected more condensates, or liquid formed by condensation, than they had predicted based on a classic physics model.

The finding revealed a limitation in the existing model and inspired the researchers to develop a new theory to explain the phenomenon, which they outline in an article published online March 13 in the journal Newton.

The theory is critical to the researchers’ work to develop innovative surfaces for applications such as harvesting water from air without electricity.