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Category: innovation – Page 2

Surprise Hair Loss Breakthrough: A DNA Sugar Gel Sparks Robust Regrowth

In 2024, scientists stumbled upon a potential new treatment for hereditary-patterned baldness, the most common cause of hair loss in both men and women worldwide.

It began with research on a naturally occurring sugar that helps form DNA: the ‘deoxyribose’ part of deoxyribonucleic acid.

While studying how these sugars aid wound healing in mice when applied topically, scientists at the University of Sheffield and COMSATS University in Pakistan noticed that the fur around treated lesions grew back faster than in untreated mice.

Trump’s Genesis Mission aims to build a centralized AI platform to power scientific breakthroughs

President Donald Trump has issued a new Executive Order that launches the “Genesis Mission,” an AI-focused initiative that aims to make the “most complex and powerful scientific instrument ever built.”

Deep contrastive learning enables genome-wide virtual screening

Recent breakthroughs in protein structure prediction have opened new avenues for genome-wide drug discovery, yet existing virtual screening methods remain computationally prohibitive. We present DrugCLIP, a contrastive learning framework that achieves ultrafast and accurate virtual screening, up to 10 million times faster than docking, while consistently outperforming various baselines on in silico benchmarks. In wet-lab validations, DrugCLIP achieved a 15% hit rate for norepinephrine transporter, and structures of two identified inhibitors were determined in complex with the target protein. For thyroid hormone receptor interactor 12, a target that lacks holo structures and small-molecule binders, DrugCLIP achieved a 17.5% hit rate using only AlphaFold2-predicted structures.

New Breakthrough to Restore Aging Joints Could Help Treat Osteoarthritis

A study in mice by researchers from Stanford University has traced the loss of cartilage that comes with aging to a single protein, pointing to treatments that may one day restore mobility and ease discomfort in seniors.

The protein 15-PGDH has previously been extensively linked to aging: it becomes more abundant as we get older, and interferes with the molecules that repair tissue and reduce inflammation.

That led scientists to consider whether 15-PGDH might be involved in osteoarthritis, where stress on joints leads to the breakdown of collagen in cartilage, causing inflammation and pain.

Researchers build plasma accelerator that boosts electron energy and brightness at the same time

Researchers from the Department of Energy’s SLAC National Accelerator Laboratory and the University of California, Los Angeles (UCLA), have designed innovative technology that can generate both high-energy and high-brightness electron bunches in an accelerator that is a fraction of the size of current particle accelerators.

This breakthrough has the potential to shrink the size of future particle colliders and X-ray free-electron lasers that researchers use to gain insight into nature’s fundamental building blocks and processes.

In the new study, the UCLA-led team developed a novel plasma wakefield accelerator (PWFA), in which electrons gain energy by “surfing” a plasma wave rather than drawing energy from the electromagnetic field inside metal structures of conventional accelerators.

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