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Category: neuroscience – Page 4

New toothpaste stops periodontal pathogens

Periodontitis is widespread and can have serious consequences for overall health. Researchers at Fraunhofer have identified a substance that selectively inhibits only those bacteria that cause periodontitis, thereby preserving the natural balance of the oral microbiome. This technology has been further developed and commercialized as a range of oral care products by the spin-off company PerioTrap.

The oral microbiome is home to more than 700 different bacterial species, of which only a few can cause periodontitis. These adhere to dental plaque, particularly along the gum line, where they trigger inflammation (gingivitis). This can potentially lead to chronic periodontitis, which does more than just cause receding gums and loose teeth. If these bacteria enter the bloodstream, they can also contribute to the development of diabetes, rheumatic disease, arthritis, cardiovascular disease, chronic inflammatory bowel disease and even Alzheimer’s disease.

Pathogenic bacteria are killed by conventional oral care products such as alcohol-based mouthwashes and products containing the antiseptic chlorhexidine, but these also eliminate beneficial microorganisms. When the oral microbiome re-establishes itself after treatment, pathogenic bacteria such as Porphyromonas gingivalis gain an early advantage because they proliferate particularly well in inflamed gum tissue. Beneficial bacteria grow more slowly, and the oral microbiome quickly shifts back from its natural balance into dysbiosis, allowing the disease to recur.

How your brain keeps time: Consistent probability calculations help you react rapidly

Humans respond to environments that change at many different speeds. A video game player, for example, reacts to on-screen events unfolding within hundreds of milliseconds or over several seconds. A boxer anticipates an opponent’s moves—even when their timing differs from that of previous opponents. In each case, the brain predicts when events occur, prepares for what comes next and flexibly adapts to the demands of the situation.

A study by neuroscientists from the Ernst Strüngmann Institute of the Max Planck Society, Goethe University Frankfurt, the Max Planck Institute for Empirical Aesthetics, and New York University, explains how the human brain predicts the timing of future events.

The research, published in the journal Proceedings of the National Academy of Sciences, shows that the brain continuously estimates how likely something is to happen within the next three seconds—and uses this estimate to prepare fast and accurate reactions.

‘Motivation brake’ may explain why it’s so hard to get started on an unpleasant task

Most of us know the feeling: maybe it is making a difficult phone call, starting a report you fear will be criticized, or preparing a presentation that’s stressful just to think about. You understand what needs to be done, yet taking that very first step feels surprisingly hard.

When this difficulty becomes severe, it is known medically as avolition. People with avolition are not lazy or unaware: they know what they need to do, but their brain seems unable to push the “go” button.

Avolition is commonly seen in conditions such as depression, schizophrenia, and Parkinson’s disease, and it seriously disrupts a person’s ability to manage daily life and maintain social functions.

Cochlear Implant User Affect and Reported Quality of Life

In adults receiving cochlear implants, gains in positive affect and reductions in negative affect corresponded with improvements in quality-of-life scores across listening, communication, and participation domains. Strongest statistical associations were observed in social and emotional CIQOL areas, but effect sizes were small.

Importance The use of patient-reported outcome measures to assess outcomes in adults who use cochlear implants has increased, as highlighted by the inclusion of the Cochlear Implant Quality of Life (CIQOL) instruments in the Minimal Speech Testing Battery, version 3. However, the self-reported nature of these instruments raises questions regarding how psychosocial characteristics impact responses.

Objective To assess whether affect and CIQOL domain scores change over time and whether affect is associated with CIQOL domain scores.

Design, Setting, and Participants Prospective longitudinal cohort study in adult cochlear implant candidates (aged 18–89 years) meeting indications for cochlear implantation based on bilateral moderate to profound hearing loss with aided sentence recognition scores 60% or less between September 19, 2019, and October 8, 2021, in a single tertiary otolaryngology referral center. Patients receiving a second cochlear implant and those without Montreal Cognitive Assessment scores were excluded. Follow-up duration was 1 year. Data analysis was performed between October 15, 2023, and August 5, 2025.

Origin cells for common malignant brain tumor in young adults uncovered

IDH-mutant glioma, caused by abnormalities in a specific gene (IDH), is the most common malignant brain tumor among young adults under the age of 50. It is a refractory brain cancer that is difficult to treat due to its high recurrence rate.

Until now, treatment has focused primarily on removing the visible tumor mass. However, a Korean research team has discovered for the first time that normal brain cells acquire the initial IDH mutation and spread out through the cortex long before a visible tumor mass harboring additional cancer mutations forms, opening a new path for early diagnosis and treatment to suppress recurrence.

Agonist‐induced depression of cholinergic current in Aplysia bag cell neurons requires ionotropic acetylcholine receptor trafficking

Kelly H. Lee & Neil S. Magoski of Queen’s University observed that agonist-induced depression of cholinergic current in Aplysia bag cell neurons requires ionotropic acetylcholine receptor trafficking🧠 💉

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