Researchers at UT Southwestern Medical Center have discovered that a crucial developmental process in the brain’s hypothalamus may influence how susceptible individuals are to obesity. Their preclinical findings, published in Neuron, show that a transcription factor called Otp acts as a molecular “switch” that directs immature hypothalamic neurons toward either appetite-suppressing or appetite-stimulating fates—their ultimate identities as specialized cells. The researchers found that disrupting this switch alters feeding behavior and protects mice from diet-induced obesity.

“These findings show that early developmental decisions in the hypothalamus have a long-lasting impact on energy balance,” said senior author Chen Liu, Ph.D., Associate Professor of Internal Medicine and Neuroscience and an Investigator in the Peter O’Donnell Jr. Brain Institute at UT Southwestern.

“By uncovering this fate-switching program, we can begin to understand how the brain establishes lifelong metabolic set points.”

The brain’s ability to do everything from forming memories to coordinating movement relies on its cells producing the right proteins at the right time. But directly measuring this protein production, known as translation, across different types of brain cells has been a challenge.

Now, scientists at University of California School of Medicine, Scripps Research and their colleagues have developed a technology that reveals which proteins are generated by individual brain cells. The team used their method—called Ribo-STAMP—to create the first maps of protein production across nearly 20,000 individual cells in the mouse hippocampus, a brain region essential for learning and memory.

The study was published in Nature.

New research published in The Journal of Neuroscience suggests breathing acts as a pacemaker for memory. The study found that successful retrieval is linked to the respiratory cycle, synchronizing brain patterns needed to remember.

This led to the discovery that myelin swellings have a dynamic character: they can not only grow, but also shrink and even recover completely. It also turns out that the activity of the underlying nerve fibre plays an important role; more activity of the nerve fibre leads to more and bigger swellings, while less activity allows for possible recovery.

The authors show that in human multiple sclerosis tissue, myelin swelling is also dynamic and is prominent around active lesions. Science Mission sciencenewshighlights.

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An international research team have gained new insights into the dynamics of myelin swellings in the brain. Myelin swellings are considered as the precursor of lesions in the brain of people with multiple sclerosis (MS). The results have been recently published in the leading magazine Science.

MS is characterised by lesions in the brain and the spinal cord. Aside from these inflammations, damage can also be visible in the myelin; the protective layer surrounding nerve fibers. Myelin swellings are seen as a precursor for damaged myelin.

The research team used advanced microscopy techniques and different models – from zebrafish and mouse models to human brain tissue – to research the formation of this damage.