World’s first pig lung transplant in brain-dead man lasts nine days in China.
In a medical first, a pig lung was transplanted into a brain-dead human, where it functioned for nine days.
Surgeons at Guangzhou Medical University, China, performed the cross-species lung transplantation.
The recipient, a 39-year-old man who had suffered a brain hemorrhage, received the left lung from a Chinese Bama Xiang pig that had undergone genetic modifications.
University of Cambridge researchers report that inactivating dorsolateral prefrontal cortex area 46 in marmosets blunts appetitive motivation and heightens threat reactivity, with effects mediated through asymmetric left-hemisphere pathways.
The dorsolateral prefrontal cortex (dlPFC) is implicated in higher-order processes such as attention, abstract thought, working memory, and inhibitory control. It is also a target for noninvasive brain stimulation in treatment-resistant depression.
Previous studies have shown that dlPFC transcranial magnetic stimulation improves depressive and comorbid anxiety symptoms and modulates activity in subcallosal cingulate cortex area 25, a region linked to therapeutic success.
Psychotherapy leads to measurable changes in brain structure. Researchers at Martin Luther University Halle-Wittenberg (MLU) and the University of Münster have demonstrated this for the first time in a study in Translational Psychiatry by using cognitive behavioral therapy.
The team analyzed the brains of 30 patients suffering from acute depression. After therapy, most of them showed changes in areas responsible for processing emotions. The observed effects are similar to those already known from studies on medication.
Around 280 million people suffer from severe depression worldwide. This depression leads to changes in the brain mass of the anterior hippocampus and amygdala. Both areas are part of the limbic system and are primarily responsible for processing and controlling emotions. In psychotherapy, cognitive behavioral therapy (CBT) is an established method for treating depression.
While there is a vast amount of information about the human brain and how it develops and works, much of the organ is still uncharted territory. But new research published in the journal Nature is giving us new insights into a type of brain cell called the GABAergic interneuron and its role in the developing brain. These findings could help explain how conditions like autism and brain disorders in children develop.
GABAergic interneurons are a vital part of the brain. They release the neurotransmitter gamma-aminobutyric acid (GABA), which regulates brain activity by switching neurons on and off. Disruptions in their functions can lead to a number of disorders, including epilepsy, schizophrenia and autism.
Making a smoothie, going for an evening walk, or having empathy for a loved one are all examples of executive functions that are controlled by the brain’s frontal cortex. This area of the brain goes through profound change throughout adolescence, and it is during this time that abnormalities in maturing circuits can set the stage for neurodevelopmental disorders, such as schizophrenia and ADHD.
Researchers at the Del Monte Institute for Neuroscience at the University of Rochester have discovered that microglia, the brain’s immune cells, play a key role in how the brain adapts to the changes in this area during adolescence, which may transform how neurodevelopmental disorders are treated during this window and, possibly, into adulthood.
“A better understanding of the ways we can drive changes in these circuits offers new targets for disease treatment,” said Rianne Stowell, Ph.D., research assistant professor of Neuroscience at the University of Rochester Medical Center, and first author of the study out today in Nature Communications.
Two-dimensional (2D) materials, thin crystalline substances only a few atoms thick, have numerous advantageous properties compared to their three-dimensional (3D) bulk counterparts. Most notably, many of these materials allow electricity to flow through them more easily than bulk materials, have tunable bandgaps, are often also more flexible and better suited for fabricating small, compact devices.
Past studies have highlighted the promise of 2D materials for creating advanced systems, including devices that perform computations emulating the functioning of the brain (i.e., neuromorphic computing systems) and chips that can both process and store information (i.e., in-memory computing systems). One material that has been found to be particularly promising is hexagonal boron nitride (hBN), which is made up of boron and nitrogen atoms arranged in a honeycomb lattice resembling that of graphene.
This material is an excellent insulator, has a wide bandgap that makes it transparent to visible light, a good mechanical strength, and retains its performance at high temperatures. Past studies have demonstrated the potential of hBN for fabricating memristors, electronic components that can both store and process information, acting both as memories and as resistors (i.e., components that control the flow of electrical current in electronic devices).
An evolving form of therapy to treat devastating neurodegenerative disorders by injecting fresh immune cells—microglia—directly into the brain, promises a new lease on health by slowing the progression of mind-robbing conditions.
The research, underway in China, is in the pre-clinical phase of investigation and is aimed at protecting vital neurons, while at the same time, combating the early hallmarks of neurological disorders, such as Alzheimer’s disease.
So far, the microglia transplants have been performed in animal models, but they have ameliorated symptoms of neurological disease.
People often bond with strangers over the books they read or the movies they watch and build friendships that last. Scientists may now have some insight into why this happens. A study published in Nature Human Behaviour found that participants who responded similarly to the same movie clips even before meeting were more likely to become friends later.
As part of the experiment, MRI brain scans were taken of 41 graduate students who had never met each other before, while they were shown clips of movies based on science, food, sports, environment, and social events.
A total of 214 brain regions were analyzed—200 cortical regions associated with functions, such as movement, perception, and sensory processing, and 14 subcortical regions that control movement, autonomic functions, and emotions.