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Category: neuroscience – Page 9

Personalized brain stimulation shows benefit for depression

A more precise and personalized form of electric brain stimulation may be a more effective and faster treatment for people with moderate to major depression compared to other similar treatments, according to a UCLA Health study.

The study, published in JAMA Network Open, examined the effectiveness of a noninvasive brain stimulation treatment known as (HD-tDCS) in treating depression. Transcranial direct current stimulation uses electrodes placed on a patient’s scalp to deliver noninvasive, safe levels of electrical currents to targeted areas of the brain.

For depression, the treatment is used to target brain networks that regulate emotional processing and self-referential thoughts. TDCS has not been approved by the U.S. Food and Drug Administration as a treatment for depression, and into various forms of tDCS is ongoing.

Distinct psilocybin-induced oscillations observed in rat medial prefrontal cortex, with effects lasting days

Psychedelics, a class of psychoactive drugs that typically induce peculiar mental states and hallucinations, are still prohibited for recreational use in most countries worldwide. In recent years, some neuroscientists and medical researchers have been exploring the potential therapeutic effects of these drugs, focusing on the treatment of depression, anxiety and various substance use disorders.

Researchers at the University of Bristol, Compass Pathways plc and other institutes recently carried out a new study involving rats, exploring the effects of the psychedelic compound on the activity of neurons in the medial prefrontal cortex, a brain region that supports decision-making, attention and the regulation of emotions. Their paper, published in Molecular Psychiatry, outlines some of the associated with the intake of this compound, which had not yet been observed in human experiments.

“Psychedelic drugs like have profound effects on our brains and minds,” Matt Jones, Professor of Neuroscience at the University of Bristol and senior author of the paper, told Medical Xpress. “These effects are fascinating and—as a long history of psychedelic use and recent clinical trials attest—potentially beneficial. This study was driven by two interrelated questions. Firstly, how does a relatively simple, small molecule alter brain activity to completely change our mental model of the world? Secondly, can those effects be harnessed to help treat mental illness?”

Scientists reveal how the brain uses objects to find direction

We take our understanding of where we are for granted, until we lose it. When we get lost in nature or a new city, our eyes and brains kick into gear, seeking familiar objects that tell us where we are.

How our brains distinguish objects from background when finding direction, however, was largely a mystery. A new study provides valuable insight into this process, with possible implications for disorientation-causing conditions such as Alzheimer’s. The work is published in the journal Science.

The scientists, based at The Neuro (Montreal Neurological Institute-Hospital) of McGill University and the University Medical Center Göttingen, ran an experiment with mice using ultrasound imaging to measure and record brain activity. The mice were shown , either an object or a scrambled image showing no distinct object.

Clocks created from random events can probe ‘quantumness’ of universe

A newly discovered set of mathematical equations describes how to turn any sequence of random events into a clock, scientists at King’s College London reveal. The paper is published in the journal Physical Review X.

The researchers suggest that these formulas could help to understand how cells in our bodies measure time and to detect the effects of quantum mechanics in the wider world.

Studying these timekeeping processes could have far-reaching implications, helping us to understand proteins with rhythmic movements which malfunction in motor neuron disease or chemical receptors that cells use to detect harmful toxins.

Portable light-based brain monitor shows promise for dementia diagnosis

Early and accurate diagnosis of dementia remains a major challenge. Standard approaches such as MRI and PET scans can provide valuable information about brain structure and function, but they are expensive, not always accessible, and often too expensive for repeated use.

A team of researchers in the UK has now demonstrated that a compact, noninvasive technology—broadband (bNIRS)—may offer a new way to detect brain changes linked to Alzheimer’s disease, even in the early stages.

In this pilot study reported in the Journal of Biomedical Optics, scientists used bNIRS to monitor both blood oxygenation and brain metabolism in response to .

In quantum sensing, what beats beating noise? Meeting noise halfway

Noise is annoying, whether you’re trying to sleep or exploit the laws of quantum physics. Although noise from environmental disturbances will always be with us, a team including scientists at the National Institute of Standards and Technology (NIST) may have found a new way of dealing with it at the microscopic scales where quantum physics reigns. Addressing this noise could make possible the best sensors ever made, with applications ranging from health care to mineral exploration.

By taking advantage of quantum phenomena known as superposition and entanglement, researchers can measure subtle changes in the environment useful for everything from geology to GPS. But to do this, they must be able to see through the caused by environmental sources such as stray magnetic fields to detect, for example, an important signal from the brain.

New findings, detailed today in Physical Review Letters, would enable interlinked groups of quantum objects such as atoms to better sense the environment in the presence of noise. A horde of unlinked quantum objects can already outperform a conventional sensor. Linking them through the process of quantum entanglement can make them perform better still. However, entangling the group can make it vulnerable to environmental noise that causes errors, making the group lose its additional sensing advantage.

Ultra-Bright and —Stable Red and Near-Infrared Squaraine Fluorophores for In Vivo Two-Photon Imaging

Fluorescent dyes that are bright, stable, small, and biocompatible are needed for high-sensitivity two-photon imaging, but the combination of these traits has been elusive. We identified a class of squaraine derivatives with large two-photon action cross-sections (up to 10,000 GM) at near-infrared wavelengths critical for in vivo imaging. We demonstrate the biocompatibility and stability of a red-emitting squaraine-rotaxane (SeTau-647) by imaging dye-filled neurons in vivo over 5 days, and utility for sensitive subcellular imaging by synthesizing a specific peptide-conjugate label for the synaptic protein PSD-95.

How early brain structure primes itself to learn efficiently

Vision happens when patterns of light entering the eye are converted into reliable patterns of brain activity. This reliability allows the brain to recognize the same object each time it is seen. Our brains, however, are not born with this ability; instead, we develop it through visual experience. Collaborating scientists at MPFI and the Frankfurt Institute for Advanced Studies have recently discovered key circuit changes that lead to the maturation of reliable brain activity patterns.

Their findings, published in Neuron this week, are likely generalizable beyond vision, providing a framework to understand the brain’s unique ability to adapt and learn quickly during the earliest stages of development.

The brain is a highly organized structure. Like other , visual areas have structure to them, which scientists call modules. This modular organization consists of patches of neurons that activate together in response to specific information. For example, some patches of neurons activate together in response to seeing vertical stripes, while other patches activate when horizontal stripes are seen.

Alleviating head-mounted weight burden for neural imaging in freely-behaving rodents

Liu et al. present a remarkably simple yet clever method of mitigating the effects of head-mounted microscopes on mouse behavior: they tethered a helium balloon to the microscope device to counter its weight! A fun and useful engineering solution!

Link to article.

Scientific Reports — Alleviating head-mounted weight burden for neural imaging in freely-behaving rodents. Sci Rep 15, 19175 (2025). https://doi.org/10.1038/s41598-025-04300-0

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