Lifeboat Foundation

Professor Nadeem Sarwar is Corporate Vice President, Co-Founder and Head, Transformational Prevention Unit, Novo Nordisk (https://www.novonordisk.com/partnerin…), Co-Chair UK Dementia Mission (a UK Government Ministerial appointment) and Honorary Professor, University of Edinburgh Medical School.

Professor Sarwar joined Novo Nordisk in June 2023 as Corporate Vice President, Co-Founder and Head of Novo Nordisk’s new Transformational Prevention Unit (TPU) whose mission is to increase obesity-free life years, so people live healthier and longer lives. To achieve this, the TPU is establishing an integrated ecosystem that will deliver science-first, empowering, and scalable commercial solutions that predict and pre-empt obesity and its consequences through innovative partnerships, with solutions intending to push the boundaries of what is possible with drugs, genomics, microbiome, digital health, and behavioral science.

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Of the 38 million Americans who have diabetes, at least 90% have type 2, according to the Centers for Disease Control and Prevention. Type 2 diabetes occurs over time and is characterized by a loss of the cells in the pancreas that make the hormone insulin, which helps the body manage sugar.

These cells make another protein, called islet amyloid polypeptide or IAPP, which has been found clumped together in many type 2 diabetes patients. The formation of IAPP clusters is comparable to how a protein in the brains of Alzheimer’s disease patients sticks together to eventually form the signature plaques associated with that disease.

Researchers at the University of Washington have demonstrated more similarities between IAPP clusters and those in Alzheimer’s. The team previously showed that a synthetic peptide can block the formation of small, toxic Alzheimer’s protein clusters. Now, in a recently published paper in Protein Science, the researchers have used a similar peptide to block the formation of IAPP clusters.

An experimental treatment for Alzheimer’s disease involving sounds and flickering lights has shown promise in mice and people. Now, research suggests the novel approach ramps up our brain’s waste disposal networks.

By Clare Wilson

Alex Rosenberg is professor of Philosophy at Duke University and has made several important contributions to the philosophy of science, biology, and social science.

0:00 intro.
2:53 scientism.
5:09 naturalism and the manifest image.
7:25 pragmatism.
10:40 intentionality.
12:38 objections to eliminativism and truth.
14:35 consciousness.
16:50 biological functions, purposes, and the selected effects theory.
22:28 reductionism.
28:05 causality.
31:02 multiple realizability.
35:13 math.
39:45 morality.
44:51 humanism, art, and history.

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Wonderful presentation by Daniel Dennett on consciousness.

Alex Rosenberg is the R. Taylor Cole Professor of Philosophy at Duke University. His research focuses on the philosophy of biology and science more generally, mind, and economics.

/ friction.
/ discord.
/ frictionphilo.

Continue reading “Alex Rosenberg | Intentionality, Evolution, and More” »

Nobel Laureate Sir Roger Penrose on his Orch OR theory of consciousness that could change what we know about time, the universe and reality, by incorporating the physics of consciousness. Explore mind blowing facts about our reality that show consciousness in quantum mechanics.

▶️ Read the article on Forbes.com https://rb.gy/s5uzf.
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Stimulating a key brain rhythm with light and sound increases peptide release from interneurons, driving clearance of Alzheimer’s protein via the brain’s glymphatic system, new study suggests.

Scientists have identified a unique form of cell messaging occurring in the human brain, revealing just how much we still have to learn about its mysterious inner workings.

Excitingly, the discovery hints that our brains might be even more powerful units of computation than we realized.

Back in 2020, researchers from institutes in Germany and Greece reported a mechanism in the brain’s outer cortical cells that produces a novel ‘graded’ signal all on its own, one that could provide individual neurons with another way to carry out their logical functions.