The discovery hints at a new way to spot risk earlier, but scientists caution it’s far from a definitive test.
Category: neuroscience – Page 12
How the heart’s ‘little brain’ helps it function and protects it against stress
For years, scientists have known that the heart has its own network of nerves, the intrinsic cardiac nervous system (ICNS), sometimes called its “little brain.” Exactly how it functions has remained something of a mystery, but a new paper published in the journal Cell sheds light on how these heart nerves work to keep the heart beating steadily.
The heart’s nerve cells fine-tune signals coming from the brain to control heart function, including heart rate. But because they are so few, doctors have struggled to determine exactly what they do. To solve this, researchers from Yale University School of Medicine genetically engineered adult mice so their heart nerves would glow, making them much easier to study.
After locating the nerves, the team analyzed which genes were active in them. They discovered that the nerves fell into two categories, which they called Npy neurons and Ddah1 neurons.
New ultrasound technique breaches blood brain barrier to treat gliomas
In a promising sign for the potential of focused sound waves to improve care for brain tumors, UVA Health researchers have determined that tumors called gliomas may be even more receptive to targeted drug delivery than normal brain tissue.
While the research is still in its early stages, the findings help allay concerns that brain tumors might have properties that would make them stubbornly resistant to the cutting-edge approach. The UVA scientists are using tiny “microbubbles” that are activated by sound waves to open the brain’s natural protective barrier, known as the “blood-brain barrier,” so that drugs can enter exactly where needed.
Inside brain tumors, cancer cells mutate the structure of the blood-brain barrier and its function becomes unpredictable. In turn, this raises questions about how effectively focused ultrasound can deliver therapies in the brain tumor environment and what sizes of drug molecules can be delivered most effectively. The new research from UVA Health’s Focused Ultrasound Cancer Immunotherapy Center provides important insights on both fronts.
Neuron discovery could explain why some people don’t get Alzheimer’s
Some brains seem to defy Alzheimer’s. Even when the disease’s telltale plaques and tangles are present, certain individuals remain mentally sharp well into old age. This phenomenon, known as cognitive resilience, is one of the most intriguing puzzles in neuroscience today.
At the Netherlands Institute for Neuroscience, researchers led by neuroscientist Evgenia Salta have uncovered new clues. Their work suggests that resilience may depend not on the sheer number of brain cells, but on how a special class of cells, called immature neurons, respond to damage.
For decades, neuroscientists have debated whether the adult human brain retains any meaningful population of “immature” neurons, youthful-looking cells tucked inside the hippocampus.
Forgotten memories can leave silent traces in the brain
Memory is not a perfect record. Some memories fade, while others remain hidden and can be brought back by reminders. But reminders can also distort what is remembered, and scientists still know little about how the brain accurately recovers memories or forms false ones.
In a new study published in Nature Neuroscience, researchers in the group of Johannes Felsenberg trained fruit flies to associate one odor with mild electric shocks. Soon after training, the flies avoided that odor, but 24 hours later the learned avoidance had faded. When the researchers later exposed the flies to the same odor as a reminder, the aversive memory was recovered, and the flies avoided the odor again.
The reminder only worked when key parts of the original setting, such as the chamber’s texture and lighting, were unchanged, suggesting that the fly brain used both the odor and its context to bring the memory back.
Scientists find a simple routine linked to less pain and depression
Keeping a regular daily schedule may help reduce pain and depression, especially among older adults with insomnia. Researchers found that consistent times for waking, eating, socializing, and sleeping were linked to better well-being regardless of sleep quality. These routines may strengthen the body’s internal clock and limit the disruptive effects of “social jet lag.”
‘Proust’s madeleine’ finally explained by neuroscience
A team of CNRS scientists has pinpointed the brain mechanisms behind the famous “Proust’s madeleine” phenomenon, in which smells bring back vivid, emotional memories.
This work, published in PLOS Biology on July 14, 2026, shows that early-life olfactory experiences leave a lasting impression on the brain, capable of reactivating the context and emotions associated with that memory throughout our lives.
The neuroscientists revealed the central role played by neurons in the olfactory bulb, an area of the brain that continues to develop during childhood. When these neurons are reactivated in adulthood by odors we experienced in childhood, they activate cerebral circuits involved in both memory and reward.
Effective treatment of glioblastoma requires crossing the blood–brain barrier and targeting tumors including cancer stem cells: The promise of nanomedicine
Glioblastoma multiforme (GBM) is the most aggressive and lethal type of brain tumor. Both therapeutic resistance and restricted permeation of drugs across the blood–brain barrier (BBB) play a major role in the poor prognosis of GBM patients. Accumulated evidence suggests that in many human cancers, including GBM, therapeutic resistance can be attributed to a small fraction of cancer cells known as cancer stem cells (CSCs). CSCs have been shown to have stem cell-like properties that enable them to evade traditional cytotoxic therapies, and so new CSC-directed anti-cancer therapies are needed. Nanoparticles have been designed to selectively deliver payloads to relevant target cells in the body, and there is considerable interest in the use of nanoparticles for CSC-directed anti-cancer therapies.
Researchers Simulate Alzheimer’s Progression Across the Entire Brain
This hypothesis has led to a new “whole-brain” mathematical and computational model developed at the MOX Laboratory of the Department of Mathematics of Politecnico di Milano. The model is designed to describe in an integrated way the interaction between the spread of amyloid beta and the functioning of the cerebral vascular network. The aim is to provide a tool capable of simulating, on the scale of the whole organ, how small biological or vascular alterations can evolve over time and contribute to neurodegeneration. The model and the accompanying scientific study have been published in the prestigious scientific journal Computer Methods in Applied Mechanics and Engineering.
The model integrates two scales of analysis. On the one hand, it describes the dynamics of the production, transformation, diffusion and elimination of the healthy and pathological forms of amyloid beta. On the other, it describes blood flow through a “macroscopic” description of arteries, capillaries and veins, treating brain tissue as a porous medium perfused by blood vessels, through a macroscopic compartmental model. The two components are then connected to represent the possible mechanism of mutual reinforcement between protein accumulation and vascular dysfunction.
The simulations show a particularly relevant result: the brain can evolve into different states depending on the initial conditions. Small localised amounts of amyloid beta can be eliminated, allowing the system to return to a healthy state. Conversely, larger amounts can trigger a self-sustained spread of the pathology at brain scale.
Brain Dramatically Remodels Its Cellular Composition, Starting in Midlife
The aging human brain is fascinating, because in some ways, it improves with age – but we generally hear more about how it declines. That’s understandable!
After all, there are a host of neurodegenerative diseases that none of us want to end up with.
Previous research has shown that some of the seemingly inevitable declines in brain health, often seen in 70-and 80-year old brains, start in midlife.