Lifeboat Foundation

Summary: Researchers found that mutations in the Sox3 gene cause hypopituitarism, a condition where the pituitary gland produces insufficient hormones, leading to growth issues and infertility. In a study on mice, they discovered that Sox3 mutations affect brain cells called NG2 glia, which are essential for hormone production.

Treating the mice with aspirin or altering their gut microbiome restored NG2 glia levels and reversed hypopituitarism. These findings suggest that both aspirin and gut bacteria could be explored as potential treatments for people with Sox3 mutations or other hormone-related disorders.

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Podcast preview discussing the D-Theory of Time paper and the upcoming eBook release: The nature of time has long been a subject of profound inquiry within both the realms of physics and philosophy. This research paper introduces the “D-Theory of Time,” a novel conceptual framework that seeks to advance our comprehension of temporal mechanics. Departing from traditional paradigms, the D-Theory posits that time is not merely a linear progression of events but a dynamic, multidimensional construct influenced by both physical and cognitive phenomena. By integrating insights from quantum mechanics, relativity, and cognitive science, this theory offers a more holistic understanding of temporal flow and its implications on our perception of reality. Key elements include the exploration of temporal entanglement, the fluidity of past, present, and future, and the interplay between consciousness and temporal experience. This paper aims to elucidate the foundational principles of the D-Theory, provide empirical support through experimental data, and discuss its potential to resolve longstanding paradoxes in the study of time. The D-Theory of Time represents a significant upgrade to our understanding of temporal mechanics, opening new avenues for research and philosophical contemplation.

Continue reading “Temporal Mechanics: D-Theory of Time | Podcast Preview” »

Mental health issues are one of the most common causes of disability, affecting more than a billion people worldwide. Addressing mental health difficulties can present extraordinarily tough problems: what can providers do to help people in the most precarious situations? How do changes in the physical brain affect our thoughts and experiences? And at the end of the day, how can everyone get the care they need?

Answering those questions was the shared goal of the researchers who attended the Mental Health, Brain, and Behavioral Science Research Day in September. While the problems they faced were serious, the new solutions they started to build could ultimately help improve mental health care at individual and societal levels.

“We’re building something that there’s no blueprint for,” said Mark Rapaport, MD, CEO of Huntsman Mental Health Institute at the University of Utah. “We’re developing new and durable ways of addressing some of the most difficult issues we face in society.”

A Spain-based startup has successfully demonstrated the capability of its graphene-based brain-computer interface (BCI) to perform precise tumor surgery.

INBRAIN Neuroelectronics, a company specializing in brain-computer interface therapies, successfully implanted its cortical interface in a human patient.

Continue reading “‘World’s first’ graphene brain chip implanted in a cancer patient” »

This latest clue about the architecture of consciousness supports a Nobel-Prize winner’s theory about how quantum physics works in your brain.

A month-long study of a man’s brain revealed that its volume consistently shrunk over the course of each day and then reset overnight.

A new study has found that intelligence, in the form of general cognitive abilities such as perception, thinking and remembering, is more important than hitherto thought at predicting a person’s ability to complete common tasks with a PC. The study was published in the International Journal of Human-Computer Studies in August 2024.

“Our research findings are the first clear proof that cognitive abilities have a significant, independent and wide-ranging effect on people’s ability to use a computer. Contrary to what was previously thought, cognitive abilities are as important as previous experience of computer use,” says Aalto University’s Professor Antti Oulasvirta, who studied human-computer interaction extensively with his team.

The findings have implications for digital equality, say the researchers, because everyday user interfaces have simply become too complex to use. Practice alone is no longer enough, with intelligence becoming an equally critical factor in predicting performance in computer tasks.

Dopamine was long thought to play a part in the placebo effect for pain relief, but a new study is questioning its true role.

By Christa Lesté-Lasserre

For several decades, although studies of rat physiology and behavior have abounded, research on rat emotions has been limited in scope to fear, anxiety, and pain. Converging evidence for the capacity of many species to share others’ affective states has emerged, sparking interest in the empathic capacities of rats. Recent research has demonstrated that rats are a highly cooperative species and are motivated by others’ distress to prosocial actions, such as opening a door or pulling a chain to release trapped conspecifics. Studies of rat affect, cognition, and neural function provide compelling evidence that rats have some capacity to represent others’ needs, to instrumentally act to improve their well-being, and are thus capable of forms of targeted helping. Rats’ complex abilities raise the importance of integrating new measures of rat well-being into scientific research.