It’s well known that alcohol consumption is an age-old method for coping with stress. But recent research led by the University of Massachusetts Amherst has found that when such self-medication begins in early adulthood, negative cognitive effects start to show up in middle age—even after long periods of total abstinence. The study is published in the journal Alcohol, Clinical and Experimental Research.
These negative effects include a decreased ability to cope with changing situations, an increased likelihood to drink when stressed, and the kinds of cognitive decline associated with dementia and Alzheimer’s disease. The new research helps us understand how alcohol rewires the brain’s circuitry and can help suggest new approaches for helping people adapt to the long-term effects of alcohol use.
Researchers have long known that stress and alcohol have a mutually reinforcing relationship: Alcohol can help take the edge off stressful situations, but in so doing it can decrease the brain’s ability to manage stress on its own, meaning one has to keep drinking, and drinking more, in order to relieve stress from a bad day. At the same time, the more one drinks, the more stress can accrue from increasingly poor decision-making. It can be a vicious cycle that gets harder to break the more the brain’s circuitry changes. But what about the long-term effects of stress and alcohol?
Scientists have successfully reconstructed videos purely from the brain activity of mice, showing what the mice were seeing, in a new study led by UCL researchers.
Dr. Nicolas Rouleau is a neuroscientist, bioengineer, and Assistant Professor of Health Sciences at Wilfrid Laurier University. He wrote the award-winning essay, ‘An Immortal Stream of Consciousness: The scientific evidence for the survival of consciousness after permanent bodily death,’ in which he argues that the transmissive theory of consciousness may actually be more consistent with emerging scientific insights than the dominant assumption that the brain generates consciousness.
In this conversation with Hans Busstra, Rouleau shares the main arguments from his essay, which touch upon his collaboration with Dr. Michael Persinger, the inventor of the ‘God Helmet,’ and his work with Michael Levin on ‘mind blindness’—the idea that science may be searching for mind in too restricted a place by focusing almost exclusively on neurons.
Further reading and scientific references discussed in this video:
Rouleau’s BICS Essay: ‘An Immortal Stream of Consciousness: The scientific evidence for the survival of consciousness after permanent bodily death.’ https://www.bigelowinstitute.org/inde…
Rouleau, N., Levin, M., et al. (2025) (Preprint; forthcoming in Philosophical Transactions of the Royal Society). Brains and Where Else? Mapping Theories of Consciousness to Unconventional Embodiments. https://tinyurl.com/439rrn8z.
Cerebral blood flow is essential for normal brain function and often perturbed in neurological disease. If one shines a source of coherent light on perfused tissue, the detected speckles, or “grains” of light fluctuate, or “dance,” at a rate proportional to blood flow in the volume sampled by the light. In brain tissue, this concept can be harnessed to measure the cerebral blood flow index (CBFi).
However, to date, implementations of this principle for noninvasive adult human brain monitoring—collectively known as diffuse correlation spectroscopy (DCS)—have achieved limited brain sensitivity. This is because the brain is 1–2 centimeters deep beneath the scalp and skull, meaning that the light must sample the superficial tissue before reaching the brain.
While the collection points can be moved further from the source to address this issue by improving sampling of the brain, this strategy requires many photon-counting channels to detect highly attenuated light far from the source. DCS becomes prohibitively expensive as the number of channels increases.
Does the universe need observers to exist? Neil deGrasse Tyson and co-hosts Chuck Nice and Gary O’Reilly explore questions about entropy, spontaneous symmetry breaking, spectroscopy and more with astrophysicist Charles Liu.
Does the universe require observers for information to exist? From Niels Bohr and the Copenhagen interpretation to modern neuroscience and philosophy, the crew explores whether measurement creates reality or reveals it. How does the double-slit experiment fit into this? Are wave and particle behaviors determined by how we measure them?
The conversation turns to information itself. What do physicists mean by “information”? How is entropy connected to hidden information in a system? We discuss entropy through everyday examples like coin flips, burning wood, and boiling water. How does this relate to quantum computing? We explore how astronomers separate cosmic redshift from stellar motion using spectroscopy, how interstellar dust and extinction curves complicate observations, and why mapping that dust is both a challenge and a source of discovery.
We discuss why the Big Bang didn’t form a black hole, how spontaneous symmetry breaking may have split the fundamental forces, and whether science can meaningfully investigate the universe’s earliest moments. Wrapping up, the team looks ahead to multi-messenger astronomy, next-generation telescope technology, exotic ideas about the speed of light, and how information continues to reshape what we know about the cosmos.
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“When engineering a computer, you need to know the circuitry of the central processing unit. If you don’t know how everything is wired together, you can’t understand its function, optimize it or fix it when something breaks. We are approaching the brain the same way,” said study leader Boxuan Zhao, a professor of cell and developmental biology at the University of Illinois Urbana-Champaign.
“Our technology enables simultaneous mapping of thousands of neural connections with single-synapse resolution —a capability that doesn’t exist in any current technology. It is directly applicable to understanding circuit dysfunction in neurodegenerative diseases and could provide a platform for developing circuit-guided therapeutic interventions,” he said.
This study investigated whether preimplantation functional network perturbations in relation to interictal epileptiform discharges are associated with vagus nerve stimulation response in children with focal drug-resistant epilepsy.