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Category: biotech/medical – Page 8

In this study, researchers engineered an attenuated strain, Designer Bacteria 1 (DB1), which efficiently survives and proliferates in tumor tissues while being cleared in normal tissues, achieving a remarkable “tumor-targeting” effect as well as “tumor-clearing” effect.

To understand how DB1 simultaneously achieves these effects, researchers investigated the interactions between the bacteria and tumors. They discovered that DB1’s antitumor efficacy is closely linked to tissue-resident memory (TRM) CD8+ T cells within the tumor, which are reinvigorated and expanded following DB1 therapy. Interleukin-10 (IL-10) plays a crucial role in mediating this effect, with efficacy depending on the high expression of interleukin-10 receptor (IL-10R) on CD8+ TRM cells.

To investigate the molecular mechanisms underlying the high expression of IL-10R on CD8+ TRM cells, researchers conducted a series of computational and quantitative experiments. They found that IL-10 binds to IL-10R on CD8+ TRM cells, activating the STAT3 protein and further promoting IL-10R expression. This established a positive feedback loop, enabling cells to bind more IL-10 and creating a nonlinear hysteretic effect, whereby CD8+ TRM cells “memorize” previous IL-10 stimulation during tumorigenesis. The high expression of IL-10R on CD8+ TRM cells was exploited by a bacteria-induced IL-10 surge, which activated and expanded CD8+ TRM cells to clear tumor cells.

To examine the source of IL-10 within the tumor microenvironment (TME) after bacterial therapy, researchers found that tumor-associated macrophages (TAMs) upregulate IL-10 expression following DB1 stimulation via the Toll-like Receptor 4 (TLR4) signaling pathway. Interestingly, IL-10 reduced the migration speed of tumor-associated neutrophils (TANs), aiding DB1 in evading rapid clearance. These processes depended on high IL-10R expression in tumor-associated immune cells, highlighting the critical role of IL-10R hysteresis.

A research team elucidated the mechanism behind bacterial cancer therapy using a genetically engineered bacterial strain. Their findings were published in Cell.

Exploring the use of antitumor bacteria in cancer therapy dates back to the 1860s. Despite this long history, however, clinical application of bacterial-based cancer therapy has faced significant challenges in terms of safety and efficacy.

Continue reading “Designer bacteria for cancer therapy” | >

Syngenta Biotechnology China-led research, with partners in the U.S., France, the UK, Chile, the Netherlands, Argentina, and across China, has discovered that sunflowers can form viable haploid seeds through parthenogenesis in the absence of pollination. This discovery opens the possibility of a scalable doubled haploid system in sunflowers, a technique that could reduce the time needed to produce fully inbred lines from six years to ~10 months.

Some animals, including certain birds, reptiles, fish, and crustaceans like Daphnia, can reproduce without fertilization through a process known as facultative parthenogenesis. In these species, females can produce offspring without male involvement. Charles Darwin first documented unusual reproductive patterns in plants, but many aspects of plant reproduction remain poorly understood.

In most , seed formation depends on a process called double fertilization. This involves one sperm fertilizing the egg and another fertilizing a separate cell that forms the endosperm, a tissue that nourishes the embryo. Without fertilization, viable seeds rarely develop.

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Image quality often makes the difference between an amazing multimedia experience, like feeling immersed in a high-definition movie, and a visual letdown. When it comes to biomolecular imaging, the details matter even more. When scientists increase resolution in quantitative imaging, they improve accuracy and confidence in results, ultimately facilitating discoveries in studies of proteins, cells and other biomedical applications.

Scientists have long been able to look at to study their nanoscale structures and dynamics in . However, distinguishing between two closely spaced dipole emitters, which are that can emit light in specific directions and intensities, has remained a major challenge, especially when such molecules emit light at the same time and are spatially coincident, or located at nearly the same point in space.

This limitation has hindered researchers’ ability to measure the orientation and angular separation of dipoles accurately, which is vital to understanding their rotational dynamics in crowded cellular environments.

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Scientists Just Merged Human Brain Cells With AI – Here’s What Happened!
What happens when human brain cells merge with artificial intelligence? Scientists have just achieved something straight out of science fiction—combining living neurons with AI to create a hybrid intelligence system. The results are mind-blowing, and they could redefine the future of computing. But how does it work, and what does this mean for humanity?

In a groundbreaking experiment, researchers successfully integrated human brain cells with AI, creating a system that learns faster and more efficiently than traditional silicon-based computers. These “biocomputers” use lab-grown brain organoids to process information, mimicking human thought patterns while leveraging AI’s speed and scalability. The implications? Smarter, more adaptive machines that think like us.

Why is this such a big deal? Unlike conventional AI, which relies on brute-force data crunching, this hybrid system operates more like a biological brain—learning with less energy, recognizing patterns intuitively, and even showing early signs of creativity. Potential applications include ultra-fast medical diagnostics, self-improving robots, and brain-controlled prosthetics that feel truly natural.

But with great power comes big questions. Could this lead to conscious machines? Will AI eventually surpass human intelligence? And what are the ethical risks of blending biology with technology? This video breaks down the science, the possibilities, and the controversies—watch to the end for the full story.

How did scientists merge brain cells with AI? What are biocomputers? Can AI become human-like? What is hybrid intelligence? Will AI replace human brains?This video will answer all these question. Make sure you watch all the way though to not miss anything.

#ai.

Continue reading “Scientists Just Merged Human Brain Cells With AI — Here’s What Happened!” | >

Scientists found that pseudouridine helps small RNAs pass on traits and avoid immune detection, offering clues for future RNA-based treatments and how the body tells “self” from “nonself.” Not everything inside us is, strictly speaking, part of us. The closer we examine the genome, the more we co

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As you age you naturally lose neurons and muscle mass and experience a decline in fertility and wound healing ability. Previous research in animals has offered several potential techniques for turning back the biological clock in specific tissues, including exercise and calorie restriction. However, age reversal of blood cells or at whole organism level has so far been elusive.

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Discover how CERN’s research into quantum fields could revolutionize our understanding of gravity! This deep dive explores the theoretical possibilities of manipulating quantum fields and their potential connection to gravitational forces. From Einstein’s predictions to cutting-edge experiments at the Large Hadron Collider, we examine what’s really happening at the frontier of physics research.

Learn how quantum gravity research could potentially transform:

Space travel and propulsion systems 🚀

Revolutionary energy production ⚡

Medical applications and treatments 🏥

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Japanese researchers are making groundbreaking discoveries on the mechanisms of aging and working to apply them. As we age, senescent cells, or aged cells that have stopped dividing, accumulate, causing inflammation that can damage blood vessels and organs. Animal experiments have shown that removing these cells improves kidney function and reduces arteriosclerosis. They have led to the identification of a drug and development of a vaccine to eliminate the cells.

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Disrupted sleep-wake and molecular circadian rhythms are a feature of aging associated with metabolic disease and reduced levels of NAD+, yet whether changes in nucleotide metabolism control circadian behavioral and genomic rhythms remains unknown. Here, we reveal that supplementation with the NAD + precursor nicotinamide riboside (NR) markedly reprograms metabolic and stress-response pathways that decline with aging through inhibition of the clock repressor PER2. NR enhances BMAL1 chromatin binding genome-wide through PER2 K680 deacetylation, which in turn primes PER2 phosphorylation within a domain that controls nuclear transport and stability and that is mutated in human advanced sleep phase syndrome.

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Scientists created a stem cell-based method to produce high-quality mitochondria at scale, enabling effective treatments for osteoarthritis and other diseases linked to mitochondrial dysfunction. Scientists have developed a groundbreaking method to mass-produce high-quality human mitochondria, a

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