People with a progressive genetic eye disorder see more clearly after receiving engineered grafts that repair the damaged surfaces of their eyes, offering a glimpse at what future treatments could hold.
Category: biotech/medical – Page 8
Scientists Can Now Watch ‘Conversations’ Between Cells Across The Body of a Living Animal
Biology – the study of living things – can admittedly be a little reductive at times.
It’s easy to miss important connections depending on how you look at an organism. Microscopes show us the fine details of a body, dissection has helped us identify different organs, and X-rays can show us the bigger picture of internal systems.
But until now, it’s been tricky to see how living cells communicate across those systems, which traditionally have been studied in isolation, even though our bodies ultimately work as a whole.
Glycocalyxedited mesenchymal stem/stromal cell therapy in advanced osteoporosis
Mesenchymal stem/stromal cell (MSC)-based therapy holds promise for reversal of bone loss in osteoporosis. This phase 1 study establishes the safety and feasibility of intravenous administration of glycocalyx-engineered human MSCs and provides evidence that MSCs derived from the bone marrow of older individuals with osteoporosis retain clinically meaningful osteoregenerative capacity.
Defying inflammationdriven earlyonset colorectal cancer: predict, prevent, and personalize
Early-life exposure to both modifiable and nonmodifiable risk factors may induce chronic low-grade inflammation (CLGI), a silent threat potentially driving the rising incidence of early-onset colorectal cancer (EOCRC). Notably, CLGI could promote EOCRC by altering the proinflammatory and immune microenvironment that supports tumor growth and cancer development. In this review, we examine how risk factors disrupt immune homeostasis and contribute to CLGI in young individuals, thereby promoting the development of EOCRC. Additionally, identifying CLGI-specific biomarkers could aid in early detection and diagnosis, while targeting specific molecular pathways may enable personalized therapeutic interventions for EOCRC by reducing the chronic inflammatory threat.
The Cells In Your Body Fade With Age, But There May Be a Way to Reverse It
To properly understand aging, we have to understand what is slowly unravelling in individual cells.
What is it that makes our cells become less efficient and more vulnerable to disease over time, and eventually break down?
A new study, led by researchers from the Fritz Lipmann Institute (FLI) in Germany, details new findings about how the energy engine rooms of cells – organelles known as mitochondria – begin to slow down over the years.
Can Pancreatic Cancer Be Detected Early? Symptoms, Biomarkers, and New Tests
ATM
BRCA1
BRCA2
CA 19–9
CDKN2A
Circulating tumor DNA
Cancer Is Quantum — and That Could Change How We Treat It
Beneath cancer’s genetic chaos, tumor cells may be confined to just a handful of recurring states, revealing a simpler path to treatment.
Cancer is often defined by its complexity: countless mutations, shifting cell populations, and tumors that evolve under pressure. But Andrea Califano’s research points to a surprising possibility: that beneath all that variation, cancer cells may be confined to only a handful of stable states.
It is this hidden order that led Califano, a physicist by training and now a cancer researcher, to describe cancer as a “quantum disease.” The comparison is not literal; rather, it reflects the idea that tumor cells may occupy discrete biological states, much as electrons are limited to specific energy levels in an atom.