How a single strength session triggers anti-cancer proteins and shields your body from inflammation.
Category: biotech/medical – Page 11
Humanlike “teeth” have been grown in mini pigs
Lose an adult tooth, and you’re left with limited options that typically involve titanium implants or plastic dentures. But scientists are working on an alternative: lab-grown human teeth that could one day replace damaged ones.
Pamela Yelick and Weibo Zhang at Tufts University School of Dental Medicine in Boston have grown a mixture of pig and human tooth cells in pieces of pig teeth to create bioengineered structures that resemble real human teeth.
The toothlike structures represent a step toward bioengineered replacements for dental implants, say researchers behind the work.
Researchers identify protein patterns linked to chemotherapy resistance in bladder cancer
About one quarter of patients with muscle-invasive bladder cancer (MIBC) may be treated and derive a benefit with the current standard chemotherapy. To better understand why some tumors resist chemotherapy and identify better ways to treat those cancers, researchers at Baylor College of Medicine have conducted a detailed molecular analysis of MIBC tumors. The results, published in Cell Reports Medicine, offer potential new ways to identify which patients will benefit from chemotherapy and reveal possible new treatment strategies.
“One of our goals was to identify molecular markers in patient tumors that would help us predict which patients were most likely to benefit from chemotherapy and which ones might not,” said first co-author, Dr. Matthew V. Holt, director of the Lester and Sue Smith Breast Center Proteomics Laboratory at Baylor.
The researchers studied 60 MIBC tumor samples using a comprehensive multi-omics approach which included genomics (sequencing the genes of the tumor), transcriptomics (analyzing which genes are turned on or off), proteomics (the proteins produced by the tumor) and phosphoproteins (proteins with chemical tags that control their activity).
Can Dietary Sodium Reduce Grey Hair?
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Breakthrough lung cancer treatment supercharges immune cells with mitochondria
Scientists have found a way to supercharge lung cancer treatment by transplanting healthy mitochondria into tumors, which both boosts immune response and makes chemotherapy far more effective. By combining this novel method with cisplatin, researchers reversed harmful tumor metabolism and empowered immune cells to fight back, all without added toxicity.
New algorithms enable efficient machine learning with symmetric data
MIT researchers designed a computationally efficient algorithm for machine learning with symmetric data that also requires fewer data for training than conventional approaches. Their work could inform the design of faster, more accurate machine-learning models for tasks like discovering new drugs or identifying astronomical phenomena.
The Shroud of Turin matches a sculpture, not ‘real human body’: Study
A new study using 3D modeling software suggests the Shroud of Turin is not the burial cloth of Jesus Christ but a medieval work of art.
U of I lab to receive $15M for AI tool development, molecular innovation
CHAMPAIGN-URBANA, Ill. (WCIA) — The U.S. National Science Foundation has awarded a University of Illinois lab $15 million. The money will support the development of AI tools, to help scientists quickly and efficiently synthesize molecules for medicine, energy, industry and more.
The money will be going to the Molecule Maker Lab Institute (MMLI) — which is based on the U of I’s campus, in partnership between Pennsylvania State University and the Georgia Institute of Technology. U of I chemical and biomolecular engineering professor Huimin Zhao directs the lab.
Zhao said functional molecules like drugs chemicals are important in today’s society, but the process of discovering new molecules is slow and expensive. He believes AI can change that.
Scientists Use Engineered Cells to Combat Aging in Primates
As we age, our bodies gradually lose their ability to repair and regenerate. Stem cells diminish, making it increasingly difficult for tissues to heal and maintain balance. This reduction in stem cells is a hallmark of aging and a key driver of age-related diseases. Scientists have long debated whether this decline is the root cause of aging or a side effect. Efforts to use stem cell transplants to reverse aging have faced many challenges, such as ensuring the cells survive and integrate into the body without causing serious side effects, like tumors.
In a recent study published in Cell, researchers from the Chinese Academy of Sciences and Capital Medical University introduced a new type of human stem cell called senescence-resistant mesenchymal progenitor cells (SRCs) by reprogramming the genetic pathways associated with longevity. These cells, which resist aging and stress without developing tumors, were tested on elderly crab-eating macaques, which share physiological similarities with humans in their 60s and 70s.
The research team conducted a 44-week experiment on these macaques. The macaques received biweekly intravenous injections of SRCs, with a dosage of 2×106 cells per kilogram of body weight. The researchers found no adverse effects among the macaques. Detailed assessments confirmed that the transplanted cells did not cause tissue damage or tumors.
The researchers discovered that SRCs triggered a multi-system rejuvenation, reversing key markers of aging across 10 major physiological systems and 61 different tissue types. The treated macaques exhibited improved cognitive function, and tissue analyses indicated a reduction in age-related degenerative conditions such as brain atrophy, osteoporosis, fibrosis, and lipid buildup. 👍
