A Q&A with Drs. Theodore Scott Nowicki and Antoni Ribas on a first-in-human clinical trial that used engineered T cells and stem cells to create a renewable supply of cancer-fighting immune cells in patients.

The Hubble Space Telescope has released a new Picture of the Week, and this time the spotlight is on a galaxy that refuses to fit neatly into any category. The subject, known as NGC 2,775, is located about 67 million light-years away in the constellation Cancer (The Crab). At its center lies a smooth, gas-free core that looks strikingly similar to an elliptical galaxy. Surrounding it, however, is a dusty ring sprinkled with uneven clusters of young stars, giving it the appearance of a spiral galaxy. So what is it exactly: spiral, elliptical — or something in between?

Because astronomers can only observe NGC 2,775 from a single perspective, its true nature remains uncertain. Some scientists argue that it should be considered a spiral galaxy due to its delicate ring of dust and stars. Others, however, classify it as a lenticular galaxy, a transitional type that shares characteristics of both spirals and ellipticals.

Severe infection can lead to sepsis. In sepsis, the host mounts an inappropriately large inflammatory response in an attempt to clear the invading pathogen. This sustained high level of inflammation may cause tissue injury and organ failure. Later in sepsis, a paradoxical immunosuppression occurs, where the host is unable to clear the preexisting infection and is susceptible to secondary infections. A major issue with sepsis treatment is that it is difficult for physicians to ascertain which stage of sepsis the patient is in. Sepsis treatment will depend on the patient’s immune status across the spectrum of the disease, and these immune statuses are nearly polar opposites in the early and late stages of sepsis. Furthermore, there is no approved treatment that can resolve inflammation without contributing to immunosuppression within the host.

Membrane proteins are crucial for numerous biological processes and serve as important drug targets. For decades, scientists have relied on detergents to extract membrane proteins from cell membranes for structural studies.

While detergent-based approaches have significantly advanced our understanding of membrane protein structures, they present certain limitations, such as resource-intensive detergent screening and the absence of native membrane lipids, which can hinder investigations into lipid-mediated regulation.

To address these challenges, a research team led by Prof. Dang Shangyu from the Division of Life Science at the Hong Kong University of Science and Technology (HKUST) has developed a novel vesicle-based method that preserves the native lipid environment of membrane proteins, which can advance structural and functional studies.