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Category: biotech/medical – Page 15

Experimental drug reverses severe fatty liver disease by repairing the gut

An experimental drug developed at Michigan Medicine has shown the ability to reverse severe fatty liver disease in animal studies by restoring gut health. The findings, published in The Journal of Clinical Investigation, suggest that targeting the connection between the gut and liver could offer a promising new approach for treating metabolic dysfunction-associated steatohepatitis (MASH).

MASH is a serious form of fatty liver disease that affects about 7% of people worldwide. It can progress to cirrhosis, liver cancer, and liver failure, yet effective treatment options remain limited.

The investigational compound, known as DT-109, is a glycine-based tripeptide. Researchers found that it reversed MASH in animal models by interrupting a harmful biological process linking the gut and liver.

How studying oral inflammatory diseases can help researchers understand other human diseases

A team of researchers from VCU Massey Comprehensive Cancer Center, the VCU School of Dentistry and the University of Pennsylvania recently published a study in Nature Communications examining why some oral inflammatory diseases progress much more rapidly than others.

The study was co-led by Kang I. Ko, D.D.S., Ph.D., of the University of Pennsylvania; Jinze Liu, Ph.D., of VCU; and Kevin Matthew Byrd, D.D.S., Ph.D., of VCU, with co-first authors Quinn T. Easter, Ph.D., and Khoa L.A. Huynh, Ph.D. The findings identified previously unrecognized changes in blood vessels that may help researchers better understand tissue destruction in oral disease and provide insights relevant to other inflammatory conditions, including cancer.

To conduct this study, the research team used and expanded a tool they created, the Human Periodontal Atlas—the leading periodontal atlas in the world—as part of the wider Human Cell Atlas, a single-cell atlas built from existing publicly available data sets, to examine RNA patterns across different cell types.

Dr. David Sinclair: The First Human Trial of an Age-Reversal Therapy #podcast #lifespan #longevity

Harvard geneticist David Sinclair returns to explain how his lab’s age-reversal technology has moved from mice and primates into FDA-cleared human trials — starting with an attempt to reverse vision loss from glaucoma, a condition considered permanent. Sinclair breaks down the science of Yamanaka factors, why using three genes instead of four sidesteps the cancer risk, and his core thesis: make the body young enough and it can cure its own diseases.

He and James also go deep on the practical longevity playbook: NMN, NAD and Sirtuins, metformin and berberine, testosterone and muscle mass, sleep, diet, and how to separate real science from longevity misinformation. Sinclair shares his own protocol at 56, his 86-year-old father’s results, and teases a next-generation \.

Combining Senolytics and Stem Cells Shows Promise in Mice

A new study associated with Immorta Bio suggests that combining a senolytic vaccine with mesenchymal stem cells might create a synergistic impact. However, the findings rest on acute, artificially induced injury models rather than natural aging [1].

Clearing out senescent cells to help stem cells work

Mesenchymal stem cell (MSC) therapies have largely underperformed in the clinic. MSCs are connective-tissue stem cells that help mostly not by becoming new tissue but by secreting repair-promoting factors. Despite strong preclinical promise, clinical MSC trials in fibrosis, inflammation, and organ failure have shown only modest benefits [2].

Unlike other organisms

Unlike other organisms, Clytia medusae can repair damage so rapidly you can actually watch small wounds close within minutes.

Larger wounds heal in less than an hour, a rate of recovery humans can only dream of. And no scar tissue is formed.

These traits make Clytia a unique window into wound healing. The medusae are transparent, allowing researchers to watch cells move in live animals in real time. Their wounds heal rapidly, and unlike mammals there is no immune system to trigger inflammation around a wound or capillary regeneration to obscure the basic mechanics of repair. As a result, scientists can observe epithelial cells stitching damaged tissue back together.

Sia Performs “Unstoppable” To Close the 2025 Breakthrough Prize Ceremony

Multi-platinum recording artist Sia closed the Breakthrough Prize ceremony with an inspiring rendition of “Unstoppable” as all prize laureates returned to the stage to a standing ovation.
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The eleventh Breakthrough Prize awards celebrated outstanding scientific achievements, honoring scientists driving remarkable discoveries in gene editing, human diseases, the search for the fundamental laws of the Universe and pure mathematics. Held at the Barker Barker Hangar in Santa Monica, CA, presentations were given by Christina Aguilera, Drew Barrymore, MrBeast, Lily Collins, Vin Diesel, Jodie Foster, Gal Gadot, Salma Hayek Pinault, Ke Huy Quan, Gayle King, Edward Norton, Gwyneth Paltrow, Seth Rogen, Lauren Sanchez, Jeremy Strong, will.i.am, and more. With live performances by Katy Perry and Sia. Continued at https://breakthroughprize.org/News/92.

Full show: • 2025 Breakthrough Prize Ceremony: Full Show.

https://breakthroughprize.org

Uploading the Human Mind To AI Is Now REAL | Artificial Immortality | Full Documentary

If you were able to create an immortal version of yourself, would you? Until this decade, that question was the stuff of science fiction, but now experts in the fields of artificial intelligence and robotics suggest it will indeed be possible. This cinematic documentary explores the latest technological advancements in AI, robotics and biotech, and poses the question: what is the essence of the human mind, and can this be replicated? Or even more unsettling, could we one day meet cloned versions of ourselves – clones which are better, smarter, and immortal?

Stars: Bina48, Nick Bostrom, Lincoln Cannon.
This is under license from Sideways. All rights reserved.

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This unusual epigenetic modifier promotes certain cancers but suppresses others

The epigenetic modifier MLL4 has an unassuming name—the 4, for instance, indicates it’s just one in a family of such modifiers. But MLL4 is quite special: In a specific type of leukemia, it drives disease progression, while in solid tumors, it acts as a suppressor.

The paradoxical nature of MLL4 made it a compelling enigma for Rockefeller University’s Robert Roeder, a pioneer in the field of genetic transcription. Now his Laboratory of Biochemistry and Molecular Biology at Rockefeller University has used a combination of biochemistry, genetics and structural biology to find surprising new characteristics of MLL4 that expand our understanding of its range of functions, including its relationship to a tumor-suppressing protein. The findings, published in Molecular Cell, could illuminate how the MLL4 complex helps switch genes on—including cancer genes in leukemia.

“This research demonstrates that MLL4 has functions in transcription that were entirely unknown before,” says Roeder. “And because MLL4 is a key regulator of gene activity, it’s important to understand how it works—especially in cancer cells.”

Researchers find simple solution for extending the lifespan of LEDs made from glowing quantum dots

A new study led by MIT researchers could drive the development of more energy-efficient digital displays—such as flat-screen TVs, augmented and virtual reality headsets, smartphone screens, medical imaging devices and even large-area ambient lighting surfaces—that also generate richer, brighter colors.

The MIT scientists, in collaboration with researchers at Samsung, studied the microscopic changes that occur inside LEDs that use electrically excited quantum dots, which are precisely shaped nanoscale semiconductor particles that emit extremely pure colored light. The research appears in Science Advances.

Quantum dots are currently used in some of the computer and television displays with the best picture quality available. The efficiency of these displays could be further improved, and their manufacturing process further simplified, if the quantum dots could be electrically excited, as was first demonstrated in the quantum dot LED (QD-LED) structures more than 20 years ago.

Visible light triggers three-step cascade to make 3D drug-like molecules

A team led by chemist Frank Glorius, a professor at the Institute of Organic Chemistry at the University of Münster, has developed a new light-driven reaction sequence. In this triple catalysis, one reaction step triggers the next like three dominoes in a row, toppling one after the other. The molecular transformations occur sequentially in a single reaction vessel. Such one-pot synthesis is considered an ideal process because it is particularly resource- and energy-efficient.

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