Scientists at Cold Spring Harbor Laboratory have cracked open the secrets of plant stem cells, mapping key genetic regulators in maize and Arabidopsis. By using single-cell RNA sequencing, they created a gene expression atlas that identifies rare stem cell regulators, links them to crop size and productivity, and offers a new roadmap for breeding resilient, high-yield plants.
Scientists in Zurich have shown that stem cell transplants can reverse stroke damage by regenerating neurons, restoring motor functions, and even repairing blood vessels. The breakthrough not only healed mice with stroke-related impairments but also suggested that treatments could soon be adapted for humans, marking a hopeful step toward tackling one of the world’s most devastating conditions.
Australian researchers have made a major breakthrough in HIV research by repurposing the same mRNA delivery system used in COVID-19 vaccines, not to prevent infection, but as a potential strategy to find a cure.
Nearly 40 million people live with HIV worldwide. While antiretroviral therapy can suppress the virus to undetectable levels, it cannot eliminate it. HIV has a unique ability to hide in a type of white blood cells, resting CD4+ T cells, ready to re-emerge if treatment is stopped. This HIV “reservoir” has long been one of the greatest challenges in the search for a cure.
Using the same technology behind mRNA COVID-19 vaccines, researchers, led by the Peter Doherty Institute for Infection and Immunity (Doherty Institute), have discovered a new way to deliver mRNA to the elusive HIV reservoir and coax HIV out of hiding. In a laboratory-based study published in Nature Communications, the team packaged mRNA inside an entirely novel microscopic fat-like bubbles, known as lipid nanoparticles, and successfully transported it into HIV-infected cells, where it prompted the cells to expose the dormant virus.
Researchers from Professor Sharon Lewin’s laboratory at the Doherty Institute have made a major breakthrough in HIV research by repurposing the same mRNA delivery system used in COVID-19 vaccines, not to prevent infection, but as a potential strategy to find a cure.
Researchers at the University of Calgary studying a lethal lung disease called pulmonary fibrosis have found that neurons known to help detect pain are also critical for reducing harmful lung inflammation that leads to the disease.
Pulmonary fibrosis, also called lung scarring, is uncommon but it’s hard to treat and most people die within five years of diagnosis. Research to date has focused on how the lung lining gets damaged and the body’s attempts to repair the issue. The role of neurons—a complex network of cells within the nervous system that send messages between the brain, spinal cord and through the body—and the immune system has received less study.
Now a research team led by Cumming School of Medicine (CSM) physician-scientist Dr. Bryan Yipp, MD, has found specific nerve cells that normally detect pain also help control inflammation during lung fibrosis.
New research by William Chain, associate professor in the University of Delaware’s Department of Chemistry and Biochemistry, and his lab, uses a molecule found in a tropical fruit to offer hope in the fight against liver-related cancers, one of the world’s top causes of cancer deaths.
Using a process called natural product total synthesis, Chain and his lab group have invented a pathway that uses widely available chemicals to create molecules found in a guava plant that are known to fight these deadly cancers. The work was published in one of the leading chemistry publications, the international journal Angewandte Chemie.
The research provides scientists around the world with an easy and low cost method to create large amounts of the naturally-occurring molecules, and opens doors to more effective and cheaper treatments.
Nature has long been the source of lifesaving medicines, from willow bark’s natural aspirin to new discoveries in tropical fruits. Now, chemists at the University of Delaware have pioneered a way to recreate powerful molecules from guava plants that show promise against liver cancer. Their method provides a low-cost, scalable recipe for scientists worldwide, sparking collaboration and potentially transforming cancer treatment.
AlterEgo is a non-invasive, wearable, peripheral neural interface that allows humans to converse in natural language with machines, artificial intelligence assistants, services, and other people without any voice—without opening their mouth, and without externally observable movements—simply by articulating words internally. The feedback to the user is given through audio, via bone conduction, without disrupting the user’s usual auditory perception, and making the interface closed-loop. This enables a human-computer interaction that is subjectively experienced as completely internal to the human user—like speaking to one’s self.
A primary focus of this project is to help support communication for people with speech disorders including conditions like ALS (amyotrophic lateral sclerosis) and MS (multiple sclerosis). Beyond that, the system has the potential to seamlessly integrate humans and computers—such that computing, the Internet, and AI would weave into our daily life as a “second self” and augment our cognition and abilities.
The wearable system captures peripheral neural signals when internal speech articulators are volitionally and neurologically activated, during a user’s internal articulation of words. This enables a user to transmit and receive streams of information to and from a computing device or any other person without any observable action, in discretion, without unplugging the user from her environment, without invading the user’s privacy.
Scientists have discovered that the protective cell layers lining our organs operate like an electrical surveillance system, using lightning-like flashes to identify and eliminate their most energy-depleted neighbors. This cellular quality control mechanism, revealed in a new Nature study, could reshape our understanding of diseases from cancer to stroke.
The research team from King’s College London and the Francis Crick Institute uncovered this process while studying epithelial cells – the tightly packed cellular barriers that line every organ in the human body. These cells constantly turnover to maintain healthy protective layers, but researchers had long puzzled over which specific cells get selected for elimination in crowded tissues.
Using specialized microscopy, the scientists noticed something unexpected: brief, lightning-like electrical flashes around cells just before they were squeezed out and died. This electrical signature, they discovered, wasn’t random but represented a sophisticated energy-sensing mechanism that targets the cellular equivalent of the weakest links.
Researchers have provided new insights into how exercise helps lose weight. They discovered a mechanism by which the compound Lac-Phe, which is produced during exercise, reduces appetite in mice, leading to weight loss. The findings appeared in Nature Metabolism.
“Regular exercise is considered a powerful way to lose weight and to protect from obesity-associated diseases, such as diabetes or heart conditions,” said co-corresponding author Dr. Yang He, assistant professor of pediatrics—neurology at Baylor and investigator at the Duncan NRI. “Exercise helps lose weight by increasing the amount of energy the body uses; however, it is likely that other mechanisms are also involved.”
The researchers previously discovered that Lac-Phe is the most increased metabolite—a product of the body’s metabolism—in blood after intense exercise, not just in mice but also in humans and racehorses. The team’s previous work showed that giving Lac-Phe to obese mice reduced how much they ate and helped them lose weight without negative side effects. But until now, scientists didn’t fully understand how Lac-Phe works to suppress appetite.