Many different cancer treatments work to directly target the tumor or the cells around it. The immediate goal is to mitigate growth and progression, with the hope of complete eradication and long-term durable immunity. However, many barriers prevent complete treatment efficacy. Different proteins and molecules secreted by the tumor polarize the environment around it to allow tumor progression. Unfortunately, the tumor generates an advantageous environment that not only suppresses the immune system, but also dysregulates immune cells to promote the spread of cancer.

Different immune cells around the tumor, such as neutrophils, macrophages, T cells, dendritic cells, and others normally work together to elicit a robust immune response. In the context of cancer, these cells take on a pro-tumor function or are prevented from executing their function. In response, many immunotherapies work to re-activate T cells, which are responsible for eliminating infected cells. Other cancer treatments, such as chemotherapy, works to directly kill the tumor.

While various therapies work through different biological mechanisms, it is still unclear how the tumor uses nutrients to fuel its progression and block immune cell response. Metabolism is the action of a cell that builds and breaks down molecules to provide energy. In general, it has been widely accepted that tumors rely on a metabolic process known as glycolysis to fuel its mass proliferation of cells. Specifically, cells breakdown glucose for energy. Although cancer cells gain energy through glycolysis, there is still a lot that is unclear about cellular metabolism and the influence it has on the environment around the tumor.

When these energy-giving organelles thrive, so do we

Objective To improve early diagnosis of patients who have basilar artery occlusion (BAO) and to provide evidence for treatment decisions based on clinical characteristics, treatment strategies, and prognostic outcomes of cases of bilateral hearing loss as a prodromal symptom.

Methods We conducted a retrospective analysis of six patients who had BAO with an initial symptom of hearing loss. This analysis encompassed demographic data, clinical symptoms, examination findings, treatment approaches, and prognostic outcomes.

Results Six patients (mean age 62±16.5 years) presented with bilateral sudden hearing loss and were diagnosed with proximal BAO. All had subtle initial symptoms, leading to diagnostic delays (mean 13 ± 5.4 hours). Five underwent endovascular treatment (EVT), and all patients required rescue balloon angioplasty because of underlying atherosclerotic stenosis.

In cohorts of lean controls, obese participants without Type 2 Diabetes Mellitus (T2DM) and obese T2DM participants, we find that T-cell expression of senescence biomarkers is altered only in the T2D…

That, he says, is when the Universe begins to speak. “We’ve come out of that process and, through ever-deepening complexity, arrived at the ability to understand how it all took place. The Universe, in the form of humans, is now understanding its infancy, its adolescence, and its later stages. We are the place where the whole sequence has become aware of itself.”

“We really need to make use of this empirical knowledge and understand how it can help us in our own lives. How do we grow from it?” asks philosopher of science Nancy Ellen Abrams, speaking with her co-author Joel Primack. “It’s just like with medicine — we don’t make the discoveries, but we get the benefit when we’re sick.” A few thousand people, she notes, have learned to think about the Universe as a whole, based on evidence, not myth. “What people can do with this is reevaluate what we are as human beings.”

That begins, they suggest, with embracing the scale of billions of years — not just as backdrop, but as the substance of our very identity. “We are not a package of organs inside skin,” Abrams says. “We are an embodiment of the history of the Universe, literally history embodied in an incredibly emergent phenomenon here.” Seen this way, our lives gain meaning from deep time.