Lifeboat Foundation

- is focusing on the role of molecular mechanisms of aging in the pathogenesis of cardiovascular diseases, COVID19, hypertension, obesity and vascularhomeostasis. ‘ + Read more in the comments and submit📧 at the link⬇

Cell Biology of Vascular Aging.

Guest Editors: Prof. Zoltan Arany, Prof. Jalees Rehman and Prof. Gabor Csanyi.

Deputy Editor Dr. Stefano Tarantini and Editor-in-Chief Dr. Zoltan Ungvari, and the editorial team of GeroScience (Official Journal of the American Aging Association, published by Springer) invite submission of original research articles, opinion papers and review articles related to research focused on understanding the mechanisms involved in vascular aging, the factors promoting accelerated aging in vascular cells and the role of vascular cells in the pathogenesis of age-related diseases. This call-for-papers is aimed at providing a platform for the dissemination of critical novel ideas related to the mechanisms of vascular aging as well as mechanisms related to key phenotypes of vascular aging including.

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Some early breast cancer patients can safely avoid specific surgeries, according to two studies exploring ways to lessen treatment burdens.

One new study, published in the New England Journal of Medicine, examines whether removing lymph nodes is always necessary in early breast cancer. Another in the Journal of the American Medical Association suggests a new approach to a type of breast cancer called ductal carcinoma in situ, or DCIS.

The research was discussed Thursday at the San Antonio Breast Cancer Symposium.

A study in mice has found that maternal gut microbiome composition during pregnancy has long-term effects on offspring stem cell growth and development. The researchers, headed by Parag Kundu, PhD, at the Institut Pasteur of Shanghai-Chinese Academy of Sciences, found that treating pregnant mice with the common gut microbe Akkermansia muciniphila resulted in offspring that had more active stem cells in both the brain and intestinal tract. As a result the offspring were less anxious and recovered quicker from colitis, and these differences were still evident at 10 months of age.

The team showed that Akkermansia muciniphila impacted stem cell growth by altering the abundance of other gut microorganisms and increasing the microbial production of metabolites that cross the placenta and induce stem cell growth and proliferation. Exposing offspring to the bacterium after birth did not result in the same stem cell activation.

“This is a major advancement in developing microbiota-based intervention strategies to improve child health,” said Kundu, who is senior author of the team’s published paper in Cell Stem Cell, titled “Maternal gut microbiota influence stem cell function in offspring.” In their report the team stated, “These results suggest a fundamental role of the maternal microbiome in programming offsprings’ stem cells and represent a promising target for interventions.”

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Google’s new quantum computing chip, Willow, has set a groundbreaking standard by achieving unparalleled speed and precision, outperforming supercomputers in specific tasks by millions of times. This revolutionary chip enhances quantum error correction, making scalable quantum systems a reality and unlocking new possibilities for artificial intelligence, scientific research, and real-world problem-solving. Willow’s success marks a major milestone in the integration of quantum computing and AI, driving innovation across industries.

Don’t let AI leave you behind — get updates at https://airevolution.cc.

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The preprint, not yet peer-reviewed, is the latest from a global consortium that hunts down potential new genes. Ever since the Human Genome Project completed its first draft at the turn of the century, scientists have tried to decipher the genetic book of life. Buried within the four genetic letters—A, T, C, and G—and the proteins they encode is a wealth of information that could help tackle our most frustrating medical foes, such as cancer.

The Human Genome Project’s initial findings came as a surprise. Scientists found less than 30,000 genes that build our bodies and keep them running—roughly a third of that previously predicted. Now, roughly 20 years later, as the technologies that sequence our DNA or map proteins have become increasingly sophisticated, scientists are asking: “What have we missed?”

The new study filled the gap by digging into relatively unexplored portions of the genome. Called “non-coding,” these parts haven’t yet been linked to any proteins. Combining several existing datasets, the team zeroed in on thousands of potential new genes that make roughly 3,000 miniproteins.

Researchers suggest an application to FDA may be made within the next 12 months, requesting approval to carry out a human clinical trial with the gene therapy.

Tiny implantable sensors are helping University of Oregon researchers optimize the process of recovery from severe bone injuries.

Scientists at the UO’s Phil and Penny Knight Campus for Accelerating Scientific Impact have developed miniature implantable sensors that transmit real-time data about what’s happening at an injury site. In a new study, they use the technology to show that a resistance-training rehabilitation program can significantly improve femur injuries in rats in just eight weeks.

The sensors provide a window into the mechanical properties of the bone, giving scientists detailed ongoing data about the process of healing. If someday applied in humans, these sensors could allow doctors to better tailor a rehabilitation program to an individual patient, monitoring their progress and adjusting the exercises along the way.