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Mitochondria Expert: This Supplement Reversed Vascular Aging by 20 Years

Discover how MitoQ reverses vascular aging by 15–20 years! Chief Scientific Officer Dr. Mitchell reveals research on mitochondrial health, showing 42% improvement in blood flow and superior results vs CoQ10 for longevity.
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Akkermansia https://pendulumtherapeutics.sjv.io/b… Daily https://pendulumtherapeutics.sjv.io/N… OmegaQuant 5% discount Code MODERN https://omegaquant.com/shop/ OneSkin 15% Discount: Code MODERN OS-01 Face https://oneskin.pxf.io/Z6Yg0K In this comprehensive interview, Dr. Mitchell, Chief Scientific Officer at MitoQ, breaks down the revolutionary science behind mitochondrial-targeted antioxidants and their impact on aging and disease prevention. *Key Topics Covered:* • How MitoQ delivers 90% bioavailability to mitochondria vs 10% for regular CoQ10 • Clinical study showing 42% improvement in flow-mediated dilation (vascular function) • Why mitochondrial dysfunction is the root cause of aging diseases • Exercise performance benefits: improved VO2 max, peak power, and recovery • Brain health and cognitive function improvements • Cardiovascular benefits: reduced oxidized LDL, improved artery flexibility • Immune system support and inflammation reduction • Diabetes prevention through improved glucose metabolism • Proper dosing protocols and supplement combinations *Research Highlights:* ✓ 25+ clinical studies and 800+ research papers ✓ Reverses vascular aging by 15–20 years according to leading researcher Doug Seals ✓ Professional cyclists and elite athletes using MitoQ for performance ✓ Ongoing trials for frailty, cognitive function, and neurovascular health ✓ 300+ independent researchers studying MitoQ applications Learn why targeting mitochondria may be the key to preventing age-related diseases and optimizing healthspan. Discover the science-backed approach to cellular energy and antioxidant protection that’s changing how we think about aging. ⏲️Chapters 0:00 The problem with mitochondria 3:34 How Mitochondria Dysfunction Occurs with Aging 5:43 Natural Protective Mechanisms and CoQ10 7:38 The Invention of MitoQ — Superior Mitochondrial Targeting 11:15 How MitoQ Differs from CoQ10 13:31 MitoQ vs CoQ10 — Research Comparisons 17:52 Cardiovascular Benefits and Flow-Mediated Dilation 23:32 Heart Muscle Function and Immune System Effects 28:16 Exercise Performance and V2 Max Improvements 32:04 Research Funding and Collaborative Programs 36:11 Diabetes Prevention and Glucose Metabolism 39:02 Brain Health and Cognitive Benefits 44:23 Dosing Protocol and Administration Guidelines 48:04 Supplement Combinations and Future Directions 🌐Links in this video MitoQ Home page https://www.mitoq.com/ Mitochondrial Collaborative Research Program https://www.mcrp.dev/ *************************************** Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation. Audio Copyright Disclaimer Please note that we have full authorization to the music that we used in our videos as they were created using the service WeVideo which provides the rights to the music. The rights are detailed in the terms of use that can be reviewed here https://www.wevideo.com/terms-of-use and any following inquiries should be addressed to [email protected]. ************************************************ #MitoQ #Mitochondria #Longevity.
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In this comprehensive interview, Dr. Mitchell, Chief Scientific Officer at MitoQ, breaks down the revolutionary science behind mitochondrial-targeted antioxidants and their impact on aging and disease prevention.

*Key Topics Covered:*
• How MitoQ delivers 90% bioavailability to mitochondria vs 10% for regular CoQ10
• Clinical study showing 42% improvement in flow-mediated dilation (vascular function)
• Why mitochondrial dysfunction is the root cause of aging diseases.
• Exercise performance benefits: improved VO2 max, peak power, and recovery.
• Brain health and cognitive function improvements.
• Cardiovascular benefits: reduced oxidized LDL, improved artery flexibility.
• Immune system support and inflammation reduction.
• Diabetes prevention through improved glucose metabolism.
• Proper dosing protocols and supplement combinations.

*Research Highlights:*
✓ 25+ clinical studies and 800+ research papers.
✓ Reverses vascular aging by 15–20 years according to leading researcher Doug Seals.
✓ Professional cyclists and elite athletes using MitoQ for performance.
✓ Ongoing trials for frailty, cognitive function, and neurovascular health.
✓ 300+ independent researchers studying MitoQ applications.

Learn why targeting mitochondria may be the key to preventing age-related diseases and optimizing healthspan. Discover the science-backed approach to cellular energy and antioxidant protection that’s changing how we think about aging.

Continue reading “Mitochondria Expert: This Supplement Reversed Vascular Aging by 20 Years” | >

Efficient mRNA delivery to resting T cells to reverse HIV latency

A major hurdle to curing HIV is the persistence of integrated proviruses in resting CD4+ T cells that remain in a transcriptionally silent, latent state. One strategy to eradicate latent HIV is to activate viral transcription, followed by elimination of infected cells through virus-mediated cytotoxicity or immune-mediated clearance. We hypothesised that mRNA-lipid nanoparticle (LNP) technology would provide an opportunity to deliver mRNA encoding proteins able to reverse HIV latency in resting CD4+ T cells. Here we develop an LNP formulation (LNP X) with unprecedented potency to deliver mRNA to hard-to-transfect resting CD4+ T cells in the absence of cellular toxicity or activation. Encapsulating an mRNA encoding the HIV Tat protein, an activator of HIV transcription, LNP X enhances HIV transcription in ex vivo CD4+ T cells from people living with HIV. LNP X further enables the delivery of clustered regularly interspaced short palindromic repeats (CRISPR) activation machinery to modulate both viral and host gene transcription. These findings offer potential for the development of a range of nucleic acid-based T cell therapeutics.

Resting T cells are difficult to manipulate, and are a reservoir for latent HIV. Here, the authors develop a lipid nanoparticle formulation with the ability to transfect resting primary human T cells, enabling delivery of mRNAs that result in reactivation of latent HIV. This could help development of HIV cure strategies.

Precision at the smallest scale

Imagine a high-tech workshop where scientists and engineers craft objects so small they can’t be seen with the naked eye — or even a standard microscope. These tiny structures — nanostructures — are thousands of times smaller than a strand of hair. And they are essential for faster computers, better smartphones and life-saving medical devices.

Nanostructures are at the core of the research happening every day in the Washington Nanofabrication Facility (WNF). Part of the Institute for Nano-Engineered Systems at the UW and located in Fluke Hall, the WNF supports cutting-edge academic and industry research, prototyping and hands-on student training. Like many leading nanofabrication centers, it is part of the National Science Foundation’s National Nanotechnology Coordinated Infrastructure, a network that shares expertise and resources.

Step inside the Washington Nanofabrication Facility, where tiny tech is transforming research in quantum, chips, medicine and more.

AI Does Something Subtly Bizarre If You Make Typos While Talking to It

New research suggests that medical AI chatbots are woefully unreliable at understanding how people actually communicate their health problems.

As detailed in yet-to-be-peer-reviewed study presented last month by MIT researchers, an AI chatbot is more likely to advise a patient not to seek medical care if their messages contained typos. The errors AI is susceptible to can be as seemingly inconsequential as an extra space between words, or if the patient used slang or colorful language. And strikingly, women are disproportionately affected by this, being wrongly told not to see a doctor at a higher rate than men.

Real-time trial shows AI could speed cancer care

A new study by researchers at the Icahn School of Medicine at Mount Sinai, Memorial Sloan Kettering Cancer Center, and collaborators, suggests that artificial intelligence (AI) could significantly improve how doctors determine the best treatment for cancer patients—by enhancing how tumor samples are analyzed in the lab.

The findings, published in Nature Medicine, showed that AI can accurately predict genetic mutations from routine pathology slides—potentially reducing the need for rapid genetic testing in certain cases.

The paper is titled “Enhancing Clinical Genomics in Lung Adenocarcinoma with Real-World Deployment of a Fine-Tuned Computational Pathology Foundation Model.”

Gene-based nanotherapy offers targeted approach to drug-resistant Candida infections

Candida, a type of fungus, can spread throughout the body via the bloodstream, leading to organ damage and sepsis. Recently, the incidence of candidiasis has surged due to the increase in immunosuppressive therapies, medical implants, and transplantation.

Major autism study uncovers biologically distinct subtypes, paving the way for precision diagnosis and care

Researchers at Princeton University and the Simons Foundation have identified four clinically and biologically distinct subtypes of autism, marking a transformative step in understanding the condition’s genetic underpinnings and potential for personalized care.

Analyzing data from over 5,000 children in SPARK, an cohort study, the researchers used a computational model to group individuals based on their combinations of traits.

The team used a “person-centered” approach that considered a broad range of over 230 traits in each individual, from social interactions to to developmental milestones, rather than searching for to single traits.

Ultra-processed foods linked to higher chronic disease risks, even at low intake

Even in moderation, consumption of ultra-processed foods is linked with measurable increases in risk for chronic diseases, according to research from the Institute for Health Metrics and Evaluation at the University of Washington. Processed meat, sugar-sweetened beverages (SSBs), and trans fatty acids (TFAs) were associated with an increased disease risk, such as type 2 diabetes, ischemic heart disease (IHD), and colorectal cancer.

Multiple previous studies have linked ultra-processed foods, particularly processed meats, sugar-sweetened beverages, and trans fatty acids, with elevated chronic disease risks. Estimates suggest that diets high in processed meat contributed to nearly 300,000 deaths worldwide in 2021, while diets rich in sugar-sweetened beverages and trans fats accounted for millions of disability-adjusted life years.

Processed meats preserved through smoking, curing or chemical additives often contain compounds such as N-nitroso agents, and heterocyclic amines—compounds implicated in tumor development.

Genome editing enables mice to produce their own weight-loss drug for months

Weight-loss drugs have surged in popularity, promising rapid results with regular injections. Now, researchers from Japan report a way for the body to make its own weight-loss drugs, doing away with injections in favor of a one-time treatment.

In the study, “Targeted In Vivo Gene Integration of a Secretion-Enabled GLP-1 receptor agonist Reverses Diet-induced Non-genetic Obesity and Pre-diabetes,” published in Communications Medicine, researchers from the University of Osaka reveal a modified genome editing approach to tackle noncommunicable, multifaceted diseases.

The approach introduced a new protein-coding gene, rather than attempting to correct a mutation in an existing gene and could be the key to lifelong effective weight management.

Universal stem cells reset immunity in a systemic sclerosis patient

Research led by Naval Medical University’s Changzheng Hospital in China reports that an off-the-shelf cell therapy built from induced pluripotent stem cells (iPSCs) loosened life-limiting skin and organ scarring in a woman with systemic sclerosis.

Systemic sclerosis progressively suffocates tissue through immune misfires, collapsed micro-vessels, and runaway collagen conditions that resist standard immunosuppressants, biologics, and anti-fibrotic drugs while driving a 40% 10-year mortality.

Cell-based approaches such as hematopoietic-stem-cell transplants and CAR-T therapies have shown promise but carry high toxicity or labor-intensive custom manufacturing, leaving clinicians and patients in search of safer, more accessible tools.