Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 19

Researchers have developed a simple blood test to detect pancreatic cancer before it spreads to other sites in the body. The test could be used for routine screening to improve the disease’s low survival rate.

Fischer and his colleagues focused on detecting enzymes called proteases, which break down proteins and are active in tumours, even from the very early stages. They specifically looked at the activity of matrix metalloproteinases involved in chewing up collagen and the extracellular matrix, which helps tumours to invade the body.

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Despite today’s AI-driven tools for modeling a bioprocess and a host of sensors to track the progress of a bioprocess in action, an expert’s hand still plays a key role in making protein-based drugs. As Hiller put it: “The science (or art!) of preparing very concentrated feed mixtures often relies on the careful order of addition of chemicals, manipulation of pH (up and down) and temperature, and separate preparation of certain concentrated solutions before addition to the bulk feed mixture.”

Culturing cells always included some art, with a bit of superstition thrown in the mix. When I worked in a cell-culture lab in the early 1980s, there were rumors of cells dying when an incubator was moved from one side of a room to another. So people rarely moved anything. Plus, if the media included horse serum, scientists shuddered if a batch came from a different herd. Maybe some of the superstition disappeared over the decades, but some of the art remains, as Hiller confirmed.

Still, science underlies the ongoing attempt to replicate a cell’s natural environment during a bioprocess. Instead of just putting the cells in a vat filled with medium, which is the essence of batch processing, perfusion can add nutrients and remove waste. As Hiller noted, perfusion culture “is somewhat analogous to the processes that occur for cells within an organ in the body.”

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Mashour is one of a small set of clinicians and scientists trying to change that. They are increasingly bringing the tools of neuroscience into the operating room to track the brain activity of patients, and testing out anesthesia on healthy study participants. These pioneers aim to learn how to more safely anesthetize their patients, tailoring the dose to individual patients and adjusting during surgery. They also want to better understand what governs the transitions between states of consciousness and even hope to crack the code of coma.

Your brain on anesthesia

Today’s anesthetic arsenal eschews Morton’s original formula for newer, safer drugs. These include ether-based inhalants such as sevoflurane and isoflurane, and the widely used, intravenous anesthetic propofol, all of which wear off faster than early ether-based anesthetics, enabling quicker recovery. (They are also less likely to cause fires and explosions in the operating room, a regular occurrence through the first half of the 20th century.) Despite these improvements, the risks associated with excessive sedation remain high. Depending on the complexity and length of surgery, between 17 and 43 percent of patients may have cognitive problems, typically in memory and executive functions.1 These typically last only one to two weeks after surgery, but few rigorous studies have examined changes in cognitive function in the general population beyond six months after surgery.

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Wound infections are common combat injuries and can take otherwise able-bodied personnel out of operations and/or result in severe medical complications. Current standard of care relies on complicated and often time-consuming tests to identify the specific infection-inducing pathogens that caused the wound infection. Therapeutic treatments rely on broad-spectrum and high-dose antibiotics alongside surgical excision – which are not pathogen specific, drive antibiotic resistance, can have toxic side effects, require advanced medical training, and can result in high treatment costs and burden on patients. A game-changing approach to managing infection of combat wounds, particularly one that can be applied autonomously, would benefit warfighter readiness and resilience.

The BioElectronics to Sense and Treat (BEST) program seeks to meet this need by developing wearable, automated technologies that can predict and prevent a wound infection before it can occur, and to eliminate an infection if it has already taken hold. To achieve this, DARPA is seeking researchers to develop novel bioelectronic smart bandages comprised of wound infection sensor and treatment modules. The sensors should be high-resolution and provide real-time, continual monitoring of wounds based on, for example, the person’s immune state and the collection of bacteria that live in and around a wound. Data from these sensors will be used to predict if a wound will fail to heal due to infection, diagnose the infection, and regulate administration of targeted treatments – using closed-loop control to prevent or resolve infection for improved wound healing.

“Given that infection initiates at the time of injury and can take hold before aid arrives, particularly in austere environments, the earlier we can deploy these technologies, the bigger impact they will have,” noted Dr. Leonard Tender, BEST program manager. “Even if medivac occurs immediately, without the ability to prevent infection, the downstream care required to treat the surge of wound infections resulting from a large-scale combat operation could easily overwhelm care capacity.”

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Targeted Radiation: A Breakthrough in Cancer Treatment

Radiation is one of the most powerful tools for destroying tumors, but traditional radiation therapy can’t distinguish between cancerous and healthy cells, often causing harmful side effects.

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A major cybersecurity incident has exposed sensitive personal, medical and financial records of more than half a million Americans.

In a data breach notification, the Office of the Maine Attorney General says the California-based non-profit organization NorthBay Healthcare Corporation experienced an external system breach affecting 569,012 Americans.

In a notice sent to affected people, NorthBay Health says an unauthorized entity gained access to the firm’s computer systems between January 11th, 2024 and April 1st of the same year.

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The work highlights a growing focus on the chemical targeting of surrounding tissues as part of efforts to stop cancerous cells expanding to other organs.

Research highlights growing focus on surrounding tissues to help tackle most malignant forms of the disease.

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