The Yale labs of Anna Marie Pyle and Craig Wilen have developed a norovirus vaccine, effective in mouse models, that portends a new approach to vaccine development for emerging RNA viruses.
Category: biotech/medical – Page 19
AAVmediated FGF21 gene therapy promotes health span extension by wholebody tissuespecific adaptations
Bosch and colleagues described that one-time AAV-FGF21 gene therapy in aged mice induced whole-body tissue-specific adaptations, including improved metabolic and mitochondrial function, restored proteostasis, and reduced adiposity, inflammation, fibrosis, and amyloidosis, thereby maintaining systemic cell fitness, preventing multi-organ age-related pathology, and prolonging health span.
Can AI Help Detect Disease Before Your Pet Gets Sick? | Dr. Ragen McGowan — Nestlé Purina
Can AI tell how your pet feels? Dr. Ragen McGowan, Ph.D. — Director of Global Digital & AI Product Development, Nestlé Purina North America.
What if your dog or cat could tell you how they’re feeling?
Today, artificial intelligence may be giving us a new way to listen.
By continuously monitoring things like activity, eating, sleep, elimination and other behaviors, AI can begin to establish what’s normal for an individual animal — and potentially detect subtle changes that humans would never notice.
Dr. Ragen McGowan, Ph.D. is Director of Global Digital & AI Product Development at Nestlé Purina (https://www.purina.com/pet-experts/rm…
AI designs new antibodies that pass blinded laboratory tests
Researchers affiliated with UTHealth Houston, competing under the team name Novamab AI, placed among the top five teams in the international AIntibody Challenge, a blinded, prospective benchmark published in Nature Biotechnology.
The study, “A blinded, prospective benchmark of in-silico antibody discovery anchored to experimental affinity and developability,” evaluates artificial intelligence platforms for therapeutic antibody design through laboratory synthesis and experimental characterization.
Unlike retrospective computational benchmarks that evaluate models against historical data sets, the AIntibody Challenge required participating teams to design entirely new antibody sequences. The designs were independently synthesized and experimentally evaluated for binding affinity and developability—key physical and chemical traits required for clinical drug candidates.
Hyperdoped silicon photodiode advances short-wave infrared detection at room temperature
Detecting short-wave infrared (SWIR) light, a region of the electromagnetic spectrum just beyond the light visible to the human eye, could be advantageous for many real-world applications. For instance, it could enable more advanced systems for capturing images at night, as well as sophisticated medical imaging, environmental monitoring and industrial inspection technologies.
Despite their potential, most SWIR detection devices developed so far are based on expensive semiconducting materials that are often difficult to integrate with existing electronic hardware. This is because silicon, the most widely used semiconductor in the electronics industry, cannot absorb SWIR photons due to its wide band gap.
Researchers at Complutense University of Madrid have developed a silicon photodiode that can efficiently absorb SWIR light and is compatible with current electronics manufacturing processes. The new device, introduced in a paper published in Physical Review Letters, is based on silicon doped with a high concentration of tellurium (Te) atoms.
Scientists Reveal How Cells Tame One of Biology’s Most Dangerous Metals
Polyamines may protect cells from toxic iron buildup by keeping reactive iron under control.
Iron keeps cells alive, but when too much of it remains chemically reactive, the same metal can become destructive. Excess free iron can drive reactions that damage DNA, proteins, and cell membranes, creating a problem cells must constantly control.
Whitehead Institute Member Ankur Jain, former postdoc Whitney Henry, and graduate student Pushkal Sharma have identified an unexpected part of that protective system: small molecules known as polyamines.
Scientists Find a Clue to Making Brain Stimulation More Reliable
The brain’s activity immediately before stimulation may help predict its response and improve the consistency of neuromodulation.
The same brain stimulation can produce very different responses depending on when it is delivered.
A study published in Brain Stimulation, using detailed brain recordings hosted by EBRAINS, suggests that the brain’s activity immediately before stimulation can explain much of this variation and may eventually help make neuromodulation therapies more dependable.
The First Person to Live 1,000 Years
What if medicine stopped treating diseases one at a time and started repairing the human body as a system? This conversation explores why longevity research is accelerating faster than ever.
