Patients with bronchial asthma suffer from attacks of shortness of breath caused by constricted airways. “Anti-inflammatory medications are usually given to treat this, although it isn’t quite clear how inflammation and constriction correlate,” says Professor Daniela Wenzel, head of the Department of Systems Physiology in the Faculty of Medicine at Ruhr University Bochum.

“These medications often stop working at a certain point.” Furthermore, asthma patients often experience a thickening of the bronchial tissue due to the accumulation of collagen. Goblet cells also form in increasing numbers, producing mucus and making breathing even more difficult. Currently, there is no medication to counteract these changes.

Enzymes known as kinases play a critical role in cell growth, metabolism and signaling in a multitude of organisms across the tree of life—from algae to helminths to mammals. Now, scientists have developed an atlas of bacterial kinases and say their new compendium holds a motherlode of possible targets for reimagined antimicrobial drugs.

A team of researchers at the University of Georgia has zeroed in on serine-threonine kinases, regulators of cell growth and pathogenicity in a multitude of bacterial species. They say their compendium can provide guidance on research into bacterial virulence and potentially trailblazing ways to attack bacteria by inhibiting the activity of serine-threonine kinases. The team’s compendium was developed by analyzing serine-threonine kinases in nearly 26,000 strains of bacteria.

“Bacterial serine-threonine kinases regulate diverse cellular processes associated with cell growth, virulence, and pathogenicity and are evolutionarily related to the druggable eukaryotic serine-threonine kinases,” writes researcher Dr. Brady O’Boyle of the University of Georgia, lead author of the new study involving the massive atlas. O’Boyle and his team found that the number of serine-threonine kinases within bacterial genomes ranges from 1 in Escherichia coli to more than 60 in some species of Actinobacteria.

Researchers at Harvard Medical School and Brigham and Women’s Hospital designed an ingestible capsule that delivers liquid mRNA to the intestines, producing gene expression and reducing inflammation in rats.

In the largest study of its kind, researchers linked irregular sleep patterns to elevated risk for 172 diseases.

Researchers have discovered a way to make the immune system’s T cells significantly more effective at fighting cancer. By blocking a protein called Ant2, they were able to reprogram how these cells consume and generate energy—essentially rewiring their internal power supply.

This shift makes T cells more active, resilient, and better at attacking tumors. The findings open the door to new treatments that could strengthen the body’s own immune response, offering a smarter, more targeted approach to cancer therapy.

Led by Ph.D. student Omri Yosef and Prof. Michael Berger from the Faculty of Medicine at Hebrew University, in collaboration with Prof. Magdalena Huber of Philipps University of Marburg and Prof. Eyal Gottlieb of the University of Texas MD Anderson Cancer Center, the international team discovered that fine-tuning immune cells’ metabolism dramatically improves their ability to destroy cancer.