Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: biotech/medical

The core components of CRISPR-based genome-editing therapies are bacterial proteins called nucleases that can stimulate unwanted immune responses in people, increasing the chances of side effects and making these therapies potentially less effective.

Researchers at the Broad Institute of MIT and Harvard and Cyrus Biotechnology have now engineered two CRISPR nucleases, Cas9 and Cas12, to mask them from the immune system. The team identified protein sequences on each nuclease that trigger the immune system and used computational modeling to design new versions that evade immune recognition. The engineered enzymes had similar gene-editing efficiency and reduced immune responses compared to standard nucleases in mice.

Appearing today in Nature Communications, the findings could help pave the way for safer, more efficient gene therapies. The study was led by Feng Zhang, a core institute member at the Broad and an Investigator at the McGovern Institute for Brain Research at MIT.

Read more | >

A new study by researchers at the Department of Molecular Medicine at SDU sheds light on one of the most severe consequences of stroke: damage to the brain’s “cables”—the so-called nerve fibers—which leads to permanent impairments. The study, published in The Journal of Pathology, which is based on unique tissue samples from Denmark’s Brain Bank located at SDU, may pave the way for new treatments that help the brain repair itself.

A stroke occurs when the to part of the brain is blocked, leading to brain damage. Following an injury, the brain tries to repair the damaged nerve fibers by re-establishing their insulating layer, called myelin. Unfortunately, the often succeeds only partially, meaning many patients experience lasting damage to their physical and mental functions.

According to Professor Kate Lykke Lambertsen, one of the study’s lead authors, the brain has the resources to repair itself, “We need to find ways to help the cells complete their work, even under difficult conditions.”

Read more | >

Unexpected crises or events, such as the COVID-19 pandemic or natural disasters, can cause disruptions to a city’s economy. For instance, forcing businesses to temporarily close or hindering their daily operations. As businesses often rely on each other, changes in the operation of one company can cause ripple effects, like influencing its suppliers, distributors or other businesses it depends on.

To explore the widespread economic impact of shocks and adverse events, past studies primarily examined the proximity between businesses, assuming that businesses are primarily connected to nearby companies or establishments. However, some findings suggest that people’s movements between businesses (i.e., behavior-based dependencies) also contribute to the resilience of cities following economic disruptions.

These dependencies are essentially relationships between businesses shaped by the behavior and habits of shared customers. For example, if a tech company is forced to close its offices, this might impact not only other nearby restaurants, but also gyms or other establishments located in different parts of a , which some employees typically visit before or after work.

Read more | >

Research led by the Chiba Cancer Center Research Institute in Japan has discovered a surprising way cancer evades the immune system. It essentially hacks the immune cells, transferring its own faulty mitochondrial DNA (mtDNA) into the T-cells meant to attack it.

This sneaky move weakens the immune cells, making them less effective at stopping the tumor. The findings could help explain why some cancer treatments, like immunotherapy, are effective for some patients but not others.

In the study, “Immune evasion through mitochondrial transfer in the ,” published in Nature, the multi-group collaboration looked at how cancer cells interact with tumor-infiltrating lymphocytes, a type of T-cell that typically fights tumors. The research is also featured in a News and Views piece.

Read more | >

Anxiety disorders, characterized by an excessive apprehension about real or perceived threats and dysfunctional behaviors aimed at avoiding these threats, are among the most common mental health conditions. Estimates suggest that around 4% of the world’s population, so a few hundred million people, experiences these disorders, which can have debilitating effects, significantly lowering their quality of life.

While there are currently various treatment options for , many existing medications do not prove effective for all individuals. Some neuroscientists worldwide have thus been trying to identify new promising neuro-biological targets for relieving anxiety and anxious behaviors.

Recent studies uncovered an association between anxiety disorders and the impaired functioning of the (BBB), a protective layer comprised of that regulates the flow of substances between the bloodstream and the brain. However, the precise neural mechanisms underpinning the link between BBB dysfunction and anxiety remain elusive.

Read more | >

An international team of scientists have discovered that soap could be important to helping our understanding of complex systems in the human body, such as lungs, and improving therapies for conditions such as respiratory distress syndrome.

In the last few years, researchers have found that surfactants—the molecules found in soap—can naturally find its way through a maze using the shortest path, with little penetration into dead ends.

The discovery may sound a little peculiar, but the finding mimics transport processes in complex branching networks found in the human body, such as the lungs. It may hold the key to understanding how liquids, such as certain drugs, travel through these networks, which could help medical scientists find new and more effective therapies.

Read more | >

Mice, like humans, compete for territory and mates, becoming more confident in their fighting abilities with each victory. Early on, a brain chemical called dopamine.

Dopamine is a crucial neurotransmitter involved in many important functions in the brain, particularly those related to pleasure, reward, motivation, and motor control. It plays a central role in the brain’s reward system, where it helps reinforce rewarding behaviors by increasing pleasure and satisfaction, making it critical for habit formation and addictive behaviors. Dopamine is also vital for regulating movement, and deficiencies in dopamine production are linked to neurological disorders such as Parkinson’s disease. Additionally, dopamine influences various other functions, including mood regulation, learning, and attention, making it a key focus in studies of both mental health and neurodegenerative diseases.

Read more | >

A review of the most interesting and impactful longevity related studies from December, including how gene therapy can increase telomere length and how the immune system can be used to clear senescent cells.

Contents:

1. Intro 0:00
2. Gene Therapy To Increase Telomere Length 0:48
3. Freeing The Immune System To Remove Senescent Cells 15:20
4. Using Probiotics To Help With Sarcopenia 27:39.

Canadian Content Study.

Continue reading “December 2024 Longevity Review” | >

A new technology developed at MIT enables scientists to label proteins across millions of individual cells in fully intact 3D tissues with unprecedented speed, uniformity, and versatility. Using the technology, the team was able to richly label whole rodent brains and other large tissue samples in a single day.

In their new study in Nature Biotechnology, they also demonstrate that the ability to label proteins with antibodies at the single-cell level across whole brains can reveal insights left hidden by other widely used labeling methods.

Profiling the proteins that cells are making is a staple of studies in biology, neuroscience and related fields because the proteins a cell is expressing at a given moment can reflect the functions the cell is trying to perform or its response to its circumstances, such as disease or treatment.

Read more | >