Lifeboat Foundation

Artificial intelligence has the potential to improve the analysis of medical image data. For example, algorithms based on deep learning can determine the location and size of tumors. This is the result of AutoPET, an international competition in medical image analysis, where researchers of Karlsruhe Institute of Technology (KIT) were ranked fifth.

The seven best autoPET teams report in the journal Nature Machine Intelligence on how algorithms can detect tumor lesions in positron emission tomography (PET) and computed tomography (CT).

Imaging techniques play a key role in the diagnosis of cancer. Precisely determining the location, size, and type of tumor is essential for choosing the right therapy. The most important imaging techniques include positron emission tomography (PET) and computer tomography (CT).

Colorectal cancer (CRC) remains one of the most clinically challenging malignancies facing our public health system. CRC accounts for the second and third most common cancer in males and females, respectively. In addition, CRC represents one of the most deadly cancers, expected to result in over 50,000 mortalities in 2024.

Hereditary colorectal cancer (HCRC) occurs when a parent passes a cancer gene to a child. Unfortunately, we have not identified a single gene that causes the disease. Hereditary CRC syndromes, such as hereditary non-polyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and familial adenomatous polyposis (FAP), describe a group of genetic diseases that confer a high risk of developing CRC. As our knowledge has expanded, we have learned about a growing number of genetic variants in the genes that predispose carriers to CRC. However, the precise role of some variants in the development of CRC cancer remains unclear. Uncovering more information about these variants, called variants of uncertain significance.

As our knowledge has expanded, we have learned about a growing number of genetic variants in the genes which predispose carriers to CRC. However, the precise role of some variants in the development of CRC cancer remains unclear. Uncovering more information about these variants, called variants of uncertain significance (VUS), can aid in optimizing screening and surveillance programs.

Nanotechnology is poised to transform neurological disorder treatments by overcoming the blood-brain barrier, enabling effective medication delivery for conditions like dementia and Alzheimer’s. This innovative approach also shows promise in dermatology and cancer treatment, enhancing drug absorption and targeting, while minimizing side effects. Experts at AIIMS highlighted ongoing research and potential breakthroughs expected in the next few years.

Skeletal editing has emerged as an appealing strategy for scaffold-hopping-based drug discovery, but the enantioselective single-atom skeletal editing of N-heteroarenes is challenging. Now, using trifluoromethyl N-triftosylhydrazones as carbene precursors, the enantiodivergent dearomative skeletal editing of indoles and pyrroles has been achieved through asymmetric carbon-atom insertion.

An unusual mode of energy metabolism discovered in a newly identified microbe provides fresh insights into primitive life processes and offers promising biotechnological applications.

Unearthed in the deep springs of northern California, this organism converts carbon dioxide into energy-rich chemicals using a previously unknown metabolic pathway, potentially mimicking early life mechanisms and paving the way for advancements in microbial manufacturing and biofuel production.

Discovery of Unique Microbe.

Bacteria modify their ribosomes when exposed to widely used antibiotics, according to research published in Nature Communications. The subtle changes might be enough to alter the binding site of drug targets and constitute a possible new mechanism of antibiotic resistance.

Escherichia coli is a common bacterium which is often harmless but can cause serious infections. The researchers exposed E. coli to streptomycin and kasugamycin, two drugs which treat bacterial infections. Streptomycin has been a staple in treating tuberculosis and other infections since the 1940s, while kasugamycin is less known but crucial in agricultural settings to prevent bacterial diseases in crops.

Both antibiotics tamper with bacteria’s ability to make new proteins by specifically targeting their ribosomes. These molecular structures create proteins and are themselves made of proteins and ribosomal RNA. Ribosomal RNA is often modified with chemical tags that can alter the shape and function of the ribosome. Cells use these tags to fine tune protein production.

Researchers used machine learning to optimize the process by which a tiny cage is opened to release a molecule.

Researchers have designed a tiny structure that could help deliver drugs inside the body [1]. The theoretical and computational work required machine learning to optimize the parameters for the structure, which could stick to a closed shell containing a small molecule and cause the shell to open. The results demonstrate the potential for machine learning to assist in the development of artificial systems that can perform complex biomolecular processes.

Researchers are developing artificial molecular-scale structures that could perform functions such as drug delivery or gene editing. Creating such artificial systems, however, usually entails a frustrating tradeoff. If the components are simple enough to be computationally tractable, they are unlikely to yield complex interactions. But if the components are too complex, they become harder to combine and coordinate. Machine learning can reduce the computational cost of designing useful artificial systems, according to graduate student Ryan Krueger of Harvard University.

Oxford University researchers have made a significant step toward realizing a form of “biological electricity” that could be used in a variety of bioengineering and biomedical applications, including communication with living human cells. The work was published on 28 November in the journal Science.

Iontronic devices are one of the most rapidly-growing and exciting areas in biochemical engineering. Instead of using electricity, these mimic the human brain by transmitting information via ions (charged particles), including sodium, potassium, and calcium ions.

Ultimately, iontronic devices could enable biocompatible, energy-efficient, and highly precise signaling systems, including for drug-delivery.