Read “The Physiology of Hunger,” the latest review in the Nutrition in Medicine series, by Alessio Fasano, MD, from Massachusetts General Hospital, Harvard Medical School, Harvard T.H. Chan School of Public Health, and Fondazione EBRIS.
Category: biotech/medical – Page 3
A global team has made a significant advance in understanding how bacterial plasmids contribute to antibiotic resistance.
Their findings reveal a complex mechanism involving the proteins KorB and KorA, which could lead to innovative treatments to weaken drug-resistant bacteria.
Breakthrough in Bacterial Resistance Research.
For decades, creating human skin models with physiological relevance has been a persistent challenge in dermatological research. Conventional approaches, such as rodent models and two-dimensional skin cultures, fail to replicate the complexity and functionality of human skin, particularly in aspects like appendage development. These gaps hinder progress in translating laboratory findings into effective clinical treatments. The scientific community has long recognized the urgent need for advanced skin models that authentically emulate human skin’s structure and function.
On January 16, 2025, a pivotal study (DOI: 10.1093/burnst/tkae070) published in the journal Burns & Trauma made remarkable progress in skin regeneration. Researchers discovered that employing an air-liquid interface (ALI) culture method significantly enhances hair follicle formation within hiPSC-derived skin organoids compared to traditional floating culture techniques. This breakthrough holds immense potential for advancing therapies for skin disorders and crafting next-generation skin regeneration solutions.
The research employed an ALI model with transwell membranes to cultivate hiPSC-derived skin organoids (SKOs), contrasting its efficacy with conventional floating culture methods. The results were striking—SKOs under ALI conditions exhibited superior hair follicle growth, both in quantity and structural complexity. These follicles were not only larger and more mature but also demonstrated features akin to natural hair shafts, closely mirroring in vivo hair follicle development. Moreover, ALI-cultured SKOs exhibited enhanced epidermal stratification and differentiation, signifying a more precise replication of human skin architecture. These findings underscore the promise of ALI culture in advancing skin organoid engineering, offering a sophisticated and functional platform for research and therapeutic development in dermatology.
A new study reveals that people with multiple sclerosis (MS) experience significantly higher rates of mental illness during pregnancy and the first year after childbirth, compared to those without MS.
The findings suggest a critical need for targeted mental health screening and interventions for this group, with depression and anxiety being the most prevalent conditions.
MS and mental health during pregnancy.
Xenon gas might one day be used as a treatment for Alzheimer’s disease, according to researchers from Mass General Brigham and Washington University. Don’t let its alien-sounding name frighten you. Xenon gas is commonly used as a medical aesthetic.
The researchers found that mice suffering from Alzheimer’s-like conditions saw reduced brain inflammation and a slowing of brain atrophy after inhaling xenon gas.
One of the biggest signs that xenon gas might actually be doing some good is that they even saw a reduction in amyloid plaque in the brain. These are deposits of proteins called beta-amyloids in the brain that are a hallmark of Alzheimer’s disease. The researchers think xenon is activating the brain’s immune cells to protect the brain from neurodegeneration.
W/ Dr. Andy Norman of Carnegie Mellon University. The prospects of cognitive immunology which posits mental immune systems & proceeds to investigate their functioning.
Alzheimer’s disease (AD), the most prevalent neurodegenerative disorder, continues to pose significant challenges despite advances in anti-amyloid therapies. New research from Harvard Medical School and Washington University School of Medicine, published in Science Translational Medicine, has unveiled a novel therapeutic approach: the use of inhaled xenon gas to modulate microglia and ameliorate disease progression in mouse models of AD.
How Xenon Targets Microglia
Microglia, the brain’s resident immune cells, play a dual role in neurodegeneration. While they can clear amyloid-beta (Aβ) plaques and damaged neurons, chronic activation leads to neuroinflammation, contributing to disease progression. Xenon gas, an inert anaesthetic, penetrates the blood-brain barrier and appears to modulate microglia to adopt a “pre-neurodegenerative microglia” (pre-MGnD) state.
Synapse-to-Nucleus ERK→CREB Transcriptional Signaling Requires Dendrite-to-Soma Ca2+ Propagation Mediated by L-Type Voltage–Gated Ca2+ Channels
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Researchers have identified a key pathway that links how neurons send signals to each other, or synaptic activity, to the expression of genes necessary for long-term changes in the brain, providing crucial insights into the molecular processes underlying memory formation.
“These findings illuminate a critical mechanism that connects local synaptic activity to the broader gene expression changes necessary for learning and memory,” said Mark Dell’Acqua, professor of pharmacology at the University of Colorado Anschutz Medical Campus and senior author of the study. “This paper is mainly a basic science finding of a fundamental process of what nerve cells do. Understanding this relay system not only enhances our knowledge of brain function but could also better inform therapeutic treatments for cognitive disorders.”
The nucleus where the genes that modify neuron function are controlled is a long distance away from where neurons receive input from their synapses, which are located in distant dendrites that extend like branches from the trunk of a tree. This research focuses on the cAMP-response element binding protein (CREB), a transcription factor known to regulate genes vital for dynamic changes at synapses which is essential for neuronal communication. Despite CREB’s well-documented role in supporting learning and memory, the exact mechanisms leading to CREB activation during neuronal activity remain unclear.
Using advanced microscopy techniques, graduate student Katlin Zent in Dr. Dell’Acqua’s research group revealed a crucial relay mechanism involving the activation of receptors and ion channels generating calcium signals that rapidly communicates from synapses in remote dendrite branches to the nucleus in the neuron cell body.
“Going forward, this research will enable us to better examine the way these pathways are utilized in different disease states,” said Dell’Acqua. “We could see exactly what parts of this new mechanism are interfered with and where, giving us a better idea of how this pathway affecting learning and memory is impacted. This research highlights potential targets for interventions aimed at conditions like Alzheimer’s disease and other memory-related disorders.”
The human immune system is like an army of specialized soldiers (immune cells) each with a unique role to play in fighting disease. In a new study published in Nature, led by scientists at the Allen Institute, La Jolla Institute for Immunology, and UC San Diego, researchers reveal how cells known as tissue-resident memory CD8 T cells, play unique and specialized roles based on where they are located within the small intestine.
Tissue-resident memory cells provide a local first line of defense against re-infection and call for “backup” from other immune cells and are also critical for maintaining peace in a tissue exposed to many outside pathogens.
This discovery sheds light on how tissue-resident memory CD8 T cells adapt to their location in the body, ensuring a coordinated and effective immune response and how microenvironments and cellular interactions shape this location-specific adaptation. Ultimately, location matters, and this understanding could also lead to improved immunotherapy and vaccines.
Certain melodies promote brain development in premature infants. For several years, a team of scientists have observed this phenomenon. They now know more precisely which areas of the brain react over time.
Premature infants are more likely to suffer from attention and emotional regulation disorders. For more than a decade, a team has been investigating an unexpected solution to prevent these problems: music. Scientists at the Geneva University Hospitals (HUG) exposed several cohorts of infants born at an average of 29 weeks to music.
Several of their publications, which have been widely covered in the media, underline the potential of this approach. The team’s latest study demonstrates that music boosts cerebral connectivity in the areas of the brain usually affected in preterm infants.