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Category: life extension – Page 3

Scientists use gene editing to correct harmful mitochondrial mutations in human cells

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations in mitochondrial DNA using a genetic tool known as a base editor. The results, published in the open-access journal PLOS Biology, offer new hope for people with rare genetic conditions.

Mitochondria have their own small set of DNA. Mutations in this mitochondrial DNA can lead to a wide range of maternally inherited diseases, cancer, and aging-related conditions. While the development of CRISPR technology has given scientists new ways to correct mutations in nuclear DNA, this system cannot effectively cross the mitochondrial membrane and reach mitochondrial DNA.

In the new study, the researchers used a tool called a base editor—specifically, a DdCBE (double-stranded DNA deaminase toxin A-derived cytosine ). This tool allows scientists to change a single letter in the DNA code without cutting it, and it works on mitochondrial DNA.

Tesla Robotaxi Changes Everything!

Tesla’s Robotaxi has the potential to revolutionize transportation and disrupt various industries, including car ownership, urban planning, and traditional car dealerships, with its autonomous driving technology and low-cost, hassle-free ride experience ## ## Questions to inspire discussion.

Transportation Revolution.

🚕 Q: How will Tesla’s Robotaxi network change urban transportation?

A: Tesla’s Robotaxi will make personal vehicle ownership obsolete in dense cities, offering rides at 25 cents per mile that are both cost-effective and convenient, eliminating the need for parking spaces.

🚗 Q: What makes Tesla’s Cybercab unique?

A: Cybercab is designed to be the most utilitarian vehicle ever built, featuring 50% fewer parts than the Model 3, making it highly scalable for millions of rides with wireless charging and autonomous capabilities.

Continue reading “Tesla Robotaxi Changes Everything!” | >

Exercise-induced CLCF1 attenuates age-related muscle and bone decline in mice

Aging impairs muscle and bone health, and exercise is known to mitigate this decline, partly through secreted factors. Here, the authors show that the muscle-derived factor CLCF1, which declines with age but is restored by exercise, mediates musculoskeletal benefits in aged mice.

Intercellular fluid flow, not just cell structure, governs how tissues respond to physical forces

Water makes up around 60% of the human body. More than half of this water sloshes around inside the cells that make up organs and tissues. Much of the remaining water flows in the nooks and crannies between cells, much like seawater between grains of sand.

Now, MIT engineers have found that this “intercellular” fluid plays a major role in how tissues respond when squeezed, pressed, or physically deformed. Their findings could help scientists understand how , tissues, and organs physically adapt to conditions such as aging, cancer, diabetes, and certain neuromuscular diseases.

In a paper appearing in Nature Physics, the researchers show that when a is pressed or squeezed, it is more compliant and relaxes more quickly when the fluid between its cells flows easily. When the cells are packed together and there is less room for intercellular flow, the tissue as a whole is stiffer and resists being pressed or squeezed.

Cells assembled into Anthrobots become biologically younger than the original cells they were made from

Modern humans have existed for more than 200,000 years, and each new generation has begun with a single cell—dividing, changing shape and function, organizing into tissues, organs, and limbs. With slight variations, the process has repeated billions of times with remarkable fidelity to the same body plan.

Researchers at Tufts have been on a quest to understand the code guiding individual cells to create the architecture of a human being, and to create a foundation for . As they learn more about that code, they are also looking at how to build living structures from human cells that have totally new forms and capabilities—without genetic manipulation.

To decipher that code, they took a cell from the human body and allowed it to grow in a novel environment to observe how the rules of self-organization play out.