Lifeboat Foundation

New research from the USC Viterbi School of Engineering could be key to our understanding of how the aging process works. The findings potentially pave the way for better cancer treatments and revolutionary new drugs that could vastly improve human health in the twilight years.

The work, from Assistant Professor of Chemical Engineering and Materials Science Nick Graham and his team in collaboration with Scott Fraser, Provost Professor of Biological Sciences and Biomedical Engineering, and Pin Wang, Zohrab A. Kaprielian Fellow in Engineering, was recently published in the Journal of Biological Chemistry.

“To drink from the fountain of youth, you have to figure out where the fountain of youth is, and understand what the fountain of youth is doing,” Graham said. “We’re doing the opposite; we’re trying to study the reasons cells age, so that we might be able to design treatments for better aging.”

Being forever young has long been a dream for many. Now there are new ways to slow down the aging process. Switzerland is jumping on the trend, with a growing hub of science and economic activity around staying young. Harvard Medical School’s David Sinclair says the “fountain of youth pill” could soon become a reality.

The Life Extension Foundation is a nonprofit organization whose goal is to extend the healthy human lifespan by discovering scientific methods to control aging and eradicate disease. continue

Since its inception in 1980, the Life Extension Foundation has continued its dedication to finding new scientific methods for eradicating old age, disease and death. continue .

Are you Cryo-Curious? Learn about the real facts of cryonics at the first Cryonics Symposium International.

The mission of Cryonics Symposium International is to bring leaders in the cryonics community together to learn from each other and promote the emerging science of cryonics.

With master-of-ceremonies Rudi Hoffman, the first time ever assembly of luminaries from different cryonics organizations will be presenting on the concepts behind the science and research of cryonics at the Church of Perpetual Life in Hollywood, Florida on Saturday, July 27th from 10 AM — 5 PM. The Church is located at 1855 McKinley St, Hollywood, FL 33021. This historic event is free-of-charge: donations are graciously accepted. Attendees will enjoy complimentary meals for the duration of the event. Seats are limited. RSVP is required via Eventbrite https://www.eventbrite.com/e/cryonics-symposium-internationa…———-

Researchers have discovered a new drug that targets the mTOR pathway, which is involved in aging and metabolism. It could function as a caloric restriction mimetic, bringing about similar health benefits.

The mTOR pathway

The mechanistic target of rapamycin (mTOR) pathway is a part of metabolism and is one of the four major pathways that control it; collectively, the four pathways are affected by deregulated nutrient sensing, which is a hallmark of aging.

Recently, we had the opportunity to interview Professor George Church, a well-known geneticist and rejuvenation expert whom we have previously interviewed. Prof. Church’s company, Rejuvenate Bio, will be launching a clinical trial to test a rejuvenation therapy in dogs this fall.

In your recent paper on enabling large-scale genome editing, you talked about manipulating endogenous transposable elements with the help of dead Cas9 base editors. At Ending Age-Related Diseases, Andrei Gudkov spoke about the super mutagenic phenotype that arises from the expression of LINE1 reverse transcriptase. In this context, he mentioned the possibility of the retrobiome (as he referred to it) being the main driver of all types of cellular damage, which is consequently improperly addressed due to immunosenescence. Do you share his views on the contribution of LINEs and SINEs in aging? If not, why?

Yes. That is one of the reasons why we explored the tech for editing of repeats. We are now extending this to the germline engineering of repeats.

Today, we want to highlight a recent human trial of the popular supplement nicotinamide riboside, a compound that has been shown in mice to restore NAD+ levels. The compound has had impressive results against some aspects of aging in mouse studies, and there is now some more data for NR in humans [1].

What is nicotinamide riboside?

Nicotinamide adenine dinucleotide (NAD+) is a chemical that facilitates the production of energy from sugar and is present in every cell in our body. As well as being important in energy production, it is also involved in DNA repair, cellular signaling, and many other cell functions.

Brain cells called microglia serve as the brain’s garbage crew, scarfing up bits of cellular debris. But their underperformance in aging brains contributes to neurodegeneration. Now, a possible workaround?