A review finds that restricting protein, particularly methionine, isoleucine, and valine, may improve metabolism and influence key aging pathways, largely in experimental models. Short human studies suggest metabolic benefits, but effects on lifespan remain unknown and restriction may harm people with unmet or increased protein needs.
Cells must constantly repair damage to their DNA that, if left unfixed, can lead to cell death, cancer, or accelerated ageing. EMBL researchers and their collaborators show that the Golgi complex, an organelle best known as the cell’s sorting and shipping centre, stores DNA-repair proteins and dispatches them to the nucleus when damage occurs. When DNA is damaged, the cell recruits the relevant repair proteins from the Golgi to the nucleus, matched to the type of damage, and clears the proteins it doesn’t need out of the nucleus, sequestering them back at the Golgi. This work reveals a new layer of regulation of DNA repair pathways from outside the nucleus, opening up new opportunities to modulate these pathways and to target related diseases such as cancer.
For all of human history, death has been the one certainty.
That certainty is now being challenged.
The biggest names in longevity research believe aging can be slowed, reversed, and one day eliminated. AI researchers think biology is simply another puzzle waiting to be solved. Together, they may be building the technology that changes civilization forever.
But extending life isn’t the real story.
The real story is what happens when humanity no longer has an expiration date.
This is the science, the debate, and the future of defeating aging.
Bracey et al. show that impaired antibody responses with age are primarily driven by defective T follicular helper cell maturation rather than intrinsic B cell dysfunction. They identify loss of human-specific CXCL13 + T follicular helper cells and reduced BACH2 and SOX4 as hallmarks of aging-associated humoral immune dysfunction.
Protein-fortified foods are popping up everywhere, from cereal and coffee to even protein water. But a new review covering more than 350 papers on protein restriction and aging—published July 31 in the journal Cell Press Blue—suggests that consuming less protein could have greater health benefits and could, in some cases, extend lifespan. The authors describe how protein restriction slows aging by improving metabolism, changing how cells respond to nutrients, reducing cellular damage and preserving healthy cell function.
Protein-fortified foods are popping up everywhere, from cereal and coffee to even protein water. But a new review covering over 350 papers on protein restriction and aging-publishing July 31 in the Cell Press journal Cell Press Blue-suggests that consuming less protein could have greater health benefits and could, in some cases, extend lifespan. The authors describe how protein restriction slows aging by improving metabolism, changing how cells respond to nutrients, reducing cellular damage, and preserving healthy cell function.
“It’s absolutely crystal clear that there are benefits of protein to muscle growth and exercise response of active individuals,” says Dudley Lamming, the paper’s corresponding author, of the University of Wisconsin-Madison. “But because most people are relatively sedentary, many people are likely consuming more protein than they actually need, which probably has negative health consequences.”
For decades, scientists have known that eating less calories can extend lifespan in many organisms and reduce the risk of age-related diseases like cancer. But maintaining a calorie-restricted diet is difficult for most people.
Ask most people what a brain chip does and they will tell you it reads your mind. Dr. Michael Lawton implants these devices, and he says that is not what comes off them. He is President and CEO of Barrow Neurological Institute in Phoenix, the hospital where Neuralink’s first human implant was performed, and he has completed more than 10,000 brain operations and clipped around 5,500 aneurysms. Louisa sat down with him inside Barrow to find out what the electrodes actually pick up, how far the technology has come, and where it stops.
He walks through the surgery itself. The device goes into the hand knob, one small lobule of the motor cortex, where 64 electrodes have already become 108. The threads carrying them are about a tenth the thickness of a hair, so a robot inserts them while avoiding every arteriole on the surface. You’ll hear what Nolan Arbaugh, Neuralink’s first patient, can now do with a cursor at world record speed, and why Lawton can’t keep up with him in a head to head.
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https://neuroathletics.substack.com/p… your risk of Alzheimer’s with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/yout… Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ TOPICS DISCUSSED 00:00 Intro: The Brain Surgeon at Neuralink’s First Hospital 00:39 The Guy Who Does the Cases Nobody Else Wants 02:17 A Day in the Life: 5:30am Starts and Three Surgeries 03:20 “Game Tape”: Reviewing Every Operation Like an Athlete 04:24 The Surgeon Athlete and Why Surgery Is a Physical Skill 05:32 Fifty Years From Now: What Happens to Neurosurgery 06:11 The ROSA Robot and Mapping a Seizure Focus 08:16 Deep Brain Stimulation and Hitting an Exact Target 08:52 Will We All Be Operated On by Robots? 10:02 The Brain AVM: The One Case a Robot Can’t Take 11:18 Why Bleeding Breaks a Robot: The Waymo Problem 13:15 What a Brain-Computer Interface Actually Does 14:49 The Hand Knob: 108 Electrodes in One Small Spot 15:50 Cursor Control at World Record Speed 16:31 Inside the Implant: Threads a Tenth the Width of a Hair 17:27 “No, the Chip Cannot Read Your Thoughts” 17:58 What the Device Really Reads: A Train of Spikes 19:18 From Movement to Sensation: What Comes Next 19:48 Why Restoring Sight Is So Much Harder 20:58 The 1943 Paper That Predicted All of This 22:37 Elon, Telepathy, and What’s Actually Possible 23:00 Boosting Creativity and Intelligence in 50 Years 25:10 “When I Retire, We’ll Be Treating Depression and Addiction” 26:04 Alzheimer’s: Light Therapy and the Blood-Brain Barrier 27:11 Treating the Disease vs Preventing It 28:25 10,000 Operations: How He Feels About Robots Taking Over 29:54 Neuroplasticity: How Nolan’s Brain Learned the Device 31:34 What Actually Changes at the Neuron Level 32:04 Patient Two and the Robotic Arm 32:42 5,500 Aneurysms: The Cases That Stay With Him 33:16 Cardiac Standstill: Cooling a Brain to 15 Degrees 35:46 What Separates a Great Surgeon From an Average One 36:17 Traits of Greatness: The Formula Nobody Has Cracked 37:21 The Phone Call in the Middle of a 16-Hour Surgery 39:35 “I Must Have Been Born for This” 41:26 Can You Tell How Old a Brain Is Just by Looking? 43:12 Why Alzheimer’s Is Invisible in a Living Brain 44:14 What a Neurosurgeon Does to Protect His Own Brain 44:40 “Alcohol Will Be Viewed Like Cigarettes in the 60s” 45:13 Peptides, Injectables, and Zero Supplements 46:52 The Last Generation to Operate With Open Hands 48:10 How Louisa Found Him on Twitter in 2021 48:53 The Six Mysteries of the Mind 49:14 Which One Gets Solved First, and Which May Never 50:03 Is Consciousness in the Tissue? 51:39 Memory: The Circuitry We Still Can’t Explain 53:18 Why Consciousness Is Harder Than Memory 55:12 Louisa’s Father’s Stroke 56:02 Advice for Anyone Watching a Parent Decline 56:21 His Sister’s Brain Tumor and How He Carries It 57:38 A World Where Stroke Is an Outpatient Repair 58:40 Forty Years On, Finally at the Dawn _______ Thank you to our sponsors Timeline (Mitopure): https://timeline.com/neuro Mitopure now starts at $79 Ogee: https://ogee.com Use code NEURO for a discount on the Crystal Contour Collection Kion (Kion Aminos): https://getkion.com/neuro for a 20% discount Function Health: https://functionhealth.com/LouisaNicola Use code NEURO25 for a $25 credit _______ I’m Louisa Nicola — clinical neurophysiologist — Alzheimer’s prevention specialist Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: / louisanicola_ Twitter :
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Reduce your risk of Alzheimer’s with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/yout…
TOPICS DISCUSSED
00:00 Intro: The Brain Surgeon at Neuralink’s First Hospital.
00:39 The Guy Who Does the Cases Nobody Else Wants.
02:17 A Day in the Life: 5:30am Starts and Three Surgeries.
03:20 \
