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Outer Space, Inner Space, and the Future of Networks.
Synopsis: Does the History, Dynamics, and Structure of our Universe give any evidence that it is inherently “Good”? Does it appear to be statistically protective of adapted complexity and intelligence? Which aspects of the big history of our universe appear to be random? Which are predictable? What drives universal and societal accelerating change, and why have they both been so stable? What has developed progressively in our universe, as opposed to merely evolving randomly? Will humanity’s future be to venture to the stars (outer space) or will we increasingly escape our physical universe, into physical and virtual inner space (the transcension hypothesis)? In Earth’s big history, what can we say about what has survived and improved? Do we see any progressive improvement in humanity’s thoughts or actions? When is anthropogenic risk existential or developmental (growing pains)? In either case, how can we minimize such risk? What values do well-built networks have? What can we learn about the nature of our most adaptive complex networks, to improve our personal, team, organizational, societal, global, and universal futures? I’ll touch on each of these vital questions, which I’ve been researching and writing about since 1999, and discussing with a community of scholars at Evo-Devo Universe (join us!) since 2008.

For fun background reading, see John’s Goodness of the Universe post on Centauri Dreams, and “Evolutionary Development: A Universal Perspective”, 2019.

John writes about Foresight Development (personal, team, organizational, societal, global, and universal), Accelerating Change, Evolutionary Development (Evo-Devo), Complex Adaptive Systems, Big History, Astrobiology, Outer and Inner Space, Human-Machine Merger, the Future of AI, Neuroscience, Mind Uploading, Cryonics and Brain Preservation, Postbiological Life, and the Values of Well-Built Networks.
He is CEO of Foresight University, founder of the Acceleration Studies Foundation, and co-founder of the Evo-Devo Universe research community, and the Brain Preservation Foundation. He is editor of Evolution, Development, and Complexity (Springer 2019), and Introduction to Foresight: Personal, Team, and Organizational Adaptiveness (Foresight U Press 2022). He is also author of The Transcension Hypothesis (2011), the proposal that universal development guides leading adaptive networks increasingly into physical and virtual inner space.

A talk for the ‘Stepping into the Future‘conference (April 2022).

A biomaterial that can mimic certain behaviors within biological tissues could advance regenerative medicine, disease modeling, soft robotics and more, according to researchers at Penn State.

Materials created up to this point to mimic tissues and extracellular matrices (ECMs)—the body’s biological scaffolding of proteins and molecules that surrounds and supports tissues and cells—have all had limitations that hamper their practical applications, according to the team. To overcome some of those limitations, the researchers developed a bio-based, “living” material that encompasses self-healing properties and mimics the biological response of ECMs to .

They published their results in Materials Horizons, where the research was also featured on the cover of the journal.

German scientists have created lab-grown “patches” of heart muscle tissue derived from pluripotent stem cells. Following a success with rhesus monkeys, they have obtained approval for a human trial [1].

Wear and tear

As one of the most hard-working tissues in the body, the heart muscle is subject to incessant wear and tear due to aging and various health conditions. Unsurprisingly, heart failure is one of the most common age-related causes of death.

Cryonic freezing offers a pathway to reap future medical technologies today by preserving someone for future restoration, but what would the impact of this technology be on civilization?

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Credits:
Cryonics: Frozen Civilizations.
Science & Futurism with Isaac Arthur.
Episode 273; January 14, 2021
Written, Produced & Narrated by Isaac Arthur.

Editors:

Chromatin, the mix of DNA and protein that houses each cell’s genome, is more resilient to aging than previously thought, suggests a study published in the Journal of the American Chemical Society by researchers at King’s College London.

Scientists believe this may reveal how the body can cope with the inevitable “wear-and-tear” of aging and where it may be more vulnerable to its effects, laying the groundwork for future anti-aging treatments throughout the body.

Proteins, much like the rest of the body, change when aging. This is especially the case for the that make up , which may “live” for ~100 days before being replenished and replaced. During their lifetime, proteins are stretched and distorted, or experience processes that are similar to rusting. This damage results in naturally occurring to the protein called post-translational modifications, or PTMs.

Thymic injury leads to reduced T cell production and makes patients more vulnerable to infections and cancers. Lemarquis et al. identify a population of recirculating regulatory T (Treg) cells that mediate regeneration in the injured thymus, partially through amphiregulin. An analogous population of Treg cells expressing CD39 and ICOS is found in humans, suggesting therapeutic avenues for boosting thymic regeneration to address aging-and treatment-induced immunosuppression.

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Cancer is infamously cunning, expansive and relentless. It has a talent for evading treatment, spreading throughout the body and coming back again and again. Despite a steady decline in U.S. cancer mortality rates thanks to better screening and treatments, the absolute number of deaths from cancer continues to tick up, in part because of an aging population.

In response, scientists and clinicians are taking a page from cancer’s playbook, learning to be just as cunning, expansive and relentless in their efforts to beat back the disease. Cancer is meeting its match.

“The field of oncology has been completely transformed from where it was 15 years ago — many aspects of cancer treatment resemble science fiction now,” said Steven Artandi, MD, PhD, the Laurie Kraus Lacob Director of the Stanford Cancer Institute.