Archive for the ‘life extension’ category: Page 6

May 11, 2022

35 Years Biological Age Reversal: A Case Study | Review

Posted by in categories: biotech/medical, life extension

In this video we have a look at a case study of one person who has undergone hTERT gene therapy. The paper does not identify the subject I would guess it is Liz Parrish. The gene therapy was administered two times over a period of five years.

Papers mentioned in the video:
Systemic Human Htert Aav Gene Transfer Therapy And The Effect On Telomere Length And Biological Age, A Case Report.…ase-report.

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May 11, 2022

Scientists Discover Master Gene In Mice That Could Restore Hearing Lost In Aging

Posted by in categories: life extension, neuroscience

Hearing loss is normally permanent as sensory cells responsible for transmitting frequency information from the world around us to the brain get damaged from excessive noise and lifestyle factors as we age. Up until now, it’s been challenging to selectively regrow these sensory cells that play an important part in transmitting sound through the outer and inner ear to the brain, but that might be about to change.

In a study involving mice, scientists from Northwestern University have identified a single master gene that can program ear hair cells (known as cochlear hair cells) into becoming either outer or inner ear hair cells required for hearing. The breakthrough is reported in the journal Nature.

“Our finding gives us the first clear cell switch to make one type versus the other,” said lead study author Jaime García-Añoveros, PhD, in a statement. “It will provide a previously unavailable tool to make an inner or outer hair cell. We have overcome a major hurdle.”

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May 10, 2022

Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate delays aging phenotypes in mice

Posted by in categories: biotech/medical, life extension, sex

Pharmaceutical intervention of aging requires targeting multiple pathways, thus there is rationale to test combinations of drugs targeting different but overlapping processes. In order to determine if combining drugs shown to extend lifespan and healthy aging in mice would have greater impact than any individual drug, a cocktail diet containing 14 ppm rapamycin, 1,000 ppm acarbose, and 1,000 ppm phenylbutyrate was fed to 20-month-old C57BL/6 and HET3 4-way cross mice of both sexes for three months. Mice treated with the cocktail showed a sex and strain-dependent phenotype consistent with healthy aging including decreased body fat, improved cognition, increased strength and endurance, and decreased age-related pathology compared to mice treated with individual drugs or control. The severity of age-related lesions in heart, lungs, liver, and kidney was consistently decreased in mice treated with the cocktail compared to mice treated with individual drugs or control, suggesting an interactive advantage of the three drugs. This study shows that a combination of three drugs, each previously shown to enhance lifespan and health span in mice, is able to delay aging phenotypes in middle-aged mice more effectively than any individual drug in the cocktail over a 3-month treatment period.

© 2022. The Author(s).

Conflict of interest statement.

May 10, 2022

On Longevity Escape Velocity with Aubrey de Grey & Charles Brenner

Posted by in categories: biotech/medical, life extension

For our inaugural episode of Let’s Talk Longevity, we want to figure out if we are anywhere near Longevity Escape Velocity. Defined as a hypothetical situation in which life expectancy is extended longer than the time that is passing, we decided the best conversation on it would be with its biggest advocate, Dr. Aubrey de Grey, and an equally well-known skeptic of the likelihood of it taking place, Dr. Charles Brenner. This debate did not need hosts!

Join us for the live Q&A on Twitter Spaces this Thursday, May 12th at 12 pm PDT

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May 9, 2022

Cryostasis Revival: The Recovery of Cryonics Patients through Nanomedicine

Posted by in categories: biotech/medical, computing, cryonics, life extension, nanotechnology

Cryostasis Revival by Robert Freitas is the first comprehensive technical exposition how to revive cryonics patients in the future. This 700+ page book with thousands of references, and technical color illustrations, is now available on Amazon in a limited textbook hardcover edition.

Cryostasis is an emergency medical procedure in which a human patient is placed in biological stasis at cryogenic temperatures. A cryopreserved patient can be maintained in this condition indefinitely without suffering additional degradation, but cannot yet be revived using currently available technology. This book presents the first comprehensive conceptual protocol for revival from human cryopreservation, using medical nanorobots. The revival methods presented in this book involve three stages: collecting information from preserved structure, computing how to fix damaged structure, and implementing the repair procedure using nanorobots manufactured in a nanofactory – a system for atomically precise manufacturing that is now visible on the technological horizon.

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May 9, 2022

Sirtuin 6 : Summary Of Key Points of Professor Cohen Interview | Modern Healthspan

Posted by in categories: biotech/medical, life extension, media & arts

There is a SIRT6 activator on the market but it is very expensive at a few hundred dollars.

We have had requests for a summary of the interview with Prof Cohen. This video is a summary of the key points from the interviews. As I note in the introduction, this is my interpretation of what Prof Cohen said, please check the original interviews if you have any questions. And please do feel free to let me know if you think I got something wrong!

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May 9, 2022

Longevity Research is an Economic Necessity

Posted by in categories: biotech/medical, genetics, life extension, neuroscience

It is vital to recognize the immediate economic importance of i nvesting in longevity and healthy-aging sciences.

Aging itself is a complex series of at least 300 biological processes involving more than 10% of our genetic makeup. It follows that methods to combat these effects must be a combination of sciences, from biotech to biophysics and pharmaceuticals. There is no single “silver bullet” solution.

Aging, along with the physical and mental decay that accompanies it, is still widely regarded as a natural and inevitable thing. It is not, it is a degenerative disease in which the physical integrity and structure of our cells decay each time they divide to replace old ones or as part of any healing process.

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May 8, 2022

Today @4 PM Eastern Time!

Posted by in categories: life extension, Ray Kurzweil

With Raymond Kurzweil’s co-author Dr. Terry Grossman M.D and Dr. The panel will also awnser Longevity questions live. This is your opportunity to get powerful health insights from the World’s leading thinkers in Life Extension.

Sun, May 8 at 3 PM CDT.


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May 8, 2022

Blood Test Analysis: Italian Centenarians

Posted by in categories: biotech/medical, life extension, robotics/AI, sex

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Biomarker timestamps:
Glucose 1:37
HDL 2:43
Triglycerides 4:10
RBCs, Hemoglobin 5:29
Platelets 7:16
Uric Acid 8:37
AST, ALT 11:04
Total Cholesterol 13:55
WBCs 15:47
Total Protein, Albumin, Globulin 17:38
Creatinine 21:27
BUN 22:35

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May 4, 2022

2022 Conference

Posted by in categories: cryonics, life extension

This year, the Alcor Life Extension Foundation is celebrating its 50th year. To mark the occasion, we are holding a conference on June 3–5, 2022, at the Scottsdale Resort in Scottsdale, Arizona.

The conference itself will be Alcor’s first major in-person gathering in seven years, so we’re going to “go big.” We expect members, prospective members, and others interested in life extension and the far future to turn out enthusiastically. We hope not only that our attendees will enjoy hearing from and interacting with you, but also that you may find the experience enjoyable. There is no organization quite like Alcor, after all, and very few opportunities to explore cryonics and its implications for society now and in the far future.

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