Lifeboat Foundation

Endothelial cells line at the most inner layer of blood vessels. They act to control hemostasis, arterial tone/reactivity, wound healing, tissue oxygen, and nutrient supply. With age, endothelial cells become senescent, characterized by reduced regeneration capacity, inflammation, and abnormal secretory profile. Endothelial senescence represents one of the earliest features of arterial ageing and contributes to many age-related diseases. Compared to those in arteries and veins, endothelial cells of the microcirculation exhibit a greater extent of heterogeneity. Microcirculatory endothelial senescence leads to a declined capillary density, reduced angiogenic potentials, decreased blood flow, impaired barrier properties, and hypoperfusion in a tissue or organ-dependent manner.

A genetic marker linked to premature aging was reversed in children with obesity during a six-month diet and exercise program, according to a recent study led by the Stanford School of Medicine.

Children’s telomeres — protective molecular “caps” on the chromosomes — were longer during the weight management program, then were shorter again in the year after the program ended, the study found. The research was published last month in Pediatric Obesity.

Continue reading “Healthy eating and activity reverse aging marker in kids with obesity, Stanford Medicine-led study finds” »

Superintelligent AI might solve all the world’s problems. It could cure cancer, eliminate human aging, create a world of abundance for all.

Superintelligent AI might also prove completely uncontrollable and destroy humanity, whether intentionally or as mere collateral damage in the path of achieving other goals.

The clashing viewpoints about the potential and dangers of peak AI live at the heart of the battle of techno-optimists and doomsayers, accelerationists vs doomers.

Called it. already impacting. not even a week later.

I just used AI in two films that are going to be announced soon. That kept me out of makeup for hours. In post and on set, I was able to use this AI technology to avoid ever having to sit through hours of aging makeup.

How are you thinking about approaching the threat that AI poses to certain job categories at your studio and on your productions?

Continue reading “Tyler Perry Puts $800M Studio Expansion on Hold After Seeing OpenAI’s Sora: ‘Jobs Are Going to Be Lost’” »

For this long overdue update of top longevity conferences we’ve removed 5 old events no longer happening and added a whopping 12 new ones!

We’ve put together the most up-to-date list of longevity conferences where you can learn about life-extension research in-person and online.

VATICAN CITY, Feb 21 (Reuters) — The giant bronze-and-wood canopy in the middle of St Peter’s Basilica is being gradually engulfed by scaffolding as Gian Lorenzo Bernini’s masterpiece gets its first major restoration since the mid-1700s.

The almost 30-metre-high canopy covers the high altar of the basilica, and was built on the spot where St Peter, the first pope, is believed to have been buried after dying as a Christian martyr in the reign of Roman Emperor Nero (54−68 AD).

The altar, from which only the pope can celebrate Mass, is “the cornerstone of the entire architecture of the Basilica”, Father Enzo Fortunato, head of communications for the church, said on Wednesday.

Summary: Researchers developed an artificial intelligence model that accurately determines the sex of individuals based on brain scans, with over 90% success. This breakthrough supports the theory that significant sex differences in brain organization exist, challenging long-standing controversies.

The AI model focused on dynamic MRI scans, identifying specific brain networks—such as the default mode, striatum, and limbic networks—as critical in distinguishing male from female brains.

This research not only deepens our understanding of brain development and aging but also opens new avenues for addressing sex-specific vulnerabilities in psychiatric and neurological disorders.

Ok, kids.

Steve Perry of GDF11Rejuvenation presents the seven main mechanisms of action of GDF11 and his own age reversal case in this clip.

Continue reading “AGE REVERSAL —29.5 Years!! 7 Potential Benefits Of GDF11” »

New models predict biological age more robustly by pinpointing different age-related changes and distinguishing between cause and effect.